Gene Information

Name : thyA (Aflv_1455)
Accession : YP_002315806.1
Strain : Anoxybacillus flavithermus WK1
Genome accession: NC_011567
Putative virulence/resistance : Unknown
Product : thymidylate synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0207
EC number : -
Position : 1463769 - 1464563 bp
Length : 795 bp
Strand : -
Note : ThyA; catalyzes formation of dTMP and 7,8-dihydrofolate from 5,10-methylenetetrahydrofolate and dUMP; involved in deoxyribonucleotide biosynthesis; there are 2 copies in some Bacilli, one of which appears to be phage-derived

DNA sequence :
ATGAAGCAATATTTACAATTACTTGAAGATATTTTACAAAACGGTGTGTATAAAGATGACCGTACGGGGACGGGAACGCT
TTCTGTATTTGGACGTCAGTTACGTTTTGATTTACGAGAAGGATTTCCTTTACTGACAACAAAAAAATTACATATTCGTT
CCATTATTCATGAATTGCTTTGGTTTTTGAGCGGAGATACGAATATTCGCTATTTAAAAGAAAATGGTGTAACGATTTGG
GATGAATGGGCAGATGAAAAGGGAGATTTAGGACCGGTGTACGGAGCGCAATGGCGTTCGTGGAGAGGAGCAGACGGACG
AACGATTGATCAAATAAGTGAAGTGATTGAACAAATAAAAACAAATCCAAACTCCCGCCGTCTTTTAGTGAGCGCGTGGA
ACGTTGCAGAATTAGATCATATGAAGTTGCCACCTTGTCATTATGCTTTTCAGTTTTATGTGGAAAACGGGACATTATCA
TGCATGTGGCAACAGCGATCTGTCGATACGTTTTTAGGTCTTCCGTTCAATATTGCAAGCTACGCGTTACTTACATATAT
GGTTGCTCAACAATGCGATCTGCAGCCGAAAGAACTTATTTTTACTGGCGGTGATGTTCATTTATATATGAATCATATTG
AGCAAGCAAAATTGCAGTTAACGAGAGAACCGCGCCCGCTCCCGAAATTGATAATCAAACGAAAACCTGCTTCTATTTTT
GAGTATCGTTTTGAAGATTTTGAAATTGTTGATTATGATCCACATCCGCATATTAAAGCGGACGTGTCTGTATAA

Protein sequence :
MKQYLQLLEDILQNGVYKDDRTGTGTLSVFGRQLRFDLREGFPLLTTKKLHIRSIIHELLWFLSGDTNIRYLKENGVTIW
DEWADEKGDLGPVYGAQWRSWRGADGRTIDQISEVIEQIKTNPNSRRLLVSAWNVAELDHMKLPPCHYAFQFYVENGTLS
CMWQQRSVDTFLGLPFNIASYALLTYMVAQQCDLQPKELIFTGGDVHLYMNHIEQAKLQLTREPRPLPKLIIKRKPASIF
EYRFEDFEIVDYDPHPHIKADVSV

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
thyA YP_001800914.1 thymidylate synthase Not tested Not named Protein 1e-77 62
thyA YP_189147.1 thymidylate synthase Not tested ¥ÕSP¥â Protein 1e-53 45