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Name : ureC (CFPG_227) Accession : YP_002308901.1 Strain : Candidatus Azobacteroides pseudotrichonymphae CFP2 Genome accession: NC_011565 Putative virulence/resistance : Virulence Product : urease subunit alpha Function : - COG functional category : E : Amino acid transport and metabolism COG ID : COG0804 EC number : - Position : 318930 - 320636 bp Length : 1707 bp Strand : - Note : ureases catalyze the hydrolysis of urea into ammonia and carbon dioxide; in Helicobacter pylori the ammonia released plays a key role in bacterial survival by neutralizing acids when colonizing the gastric mucosa; the holoenzyme is composed of 3 ureC (alp DNA sequence : ATGGCACAGATAAACAGAAAATTGTATTCTTCTATGTATGGTATTACTACGGGTGATATAGTAACTTTAGGTGATACAAA TTTGAAAATACAAGTAGAAAAGGATTATACTACTTATGGGGAAGAATGTGTCTTTGGTGGTGGTAAAGTTATTCGTGATG GTATGGGACAAGCATCGGGTTTTTGTGATGAGGAAGTATTGGATATGGTGATAACCAATGCTTTGATTATTGATTACAAG GGCATATATAAAGCTGATATAGGAATTAAAAATGGAAAAATAAAAGGCATTGGTAAAGCGGGGAACCCTCATATTCAACC TGGAGTTTCTCCTACTCTTATTATTGGCACGATTACTGAGGTTGTTTCTGGGGAGGGACGAATTTTGACGGCAGGAGCTA TTGATACCCATGTTCATTATATCAGTCCTCAGCAAGCGGATGAAGCTTTGGCTTCTGGTATTACAACTTTTGTGGGAGGA GGAACAGGACCTGCTACAGGTACTTATGCTACTACTTGTACTCCAGGTTGGTATCTTCGTAAAATGATGGAAGCAACCGA TAATATTCCTATTAATTTTGGTTTTCTTGGAAAAGGTAACTCTAGTAAATCAAAAGCTCTTGAAGGCCAAATAAAAGCAG GAGCGTTAGGTTTGAAGCTTCACGAGGATTGGGGGTCTACTCCTTCCGTTATTGATACAAGTCTTAAAGTTGCTGATGAA TATGATGTACAGATCTGTATTCATACAGATTCCATCAATGAATGTGGTTATATTGAGGACACTCTTTGTGCTATCGATGG AAGAACAATACATGCTTATCATGTTGAAGGTGCTGGTGGTGGACATGCCCCAGATATTATGAAGGCTTGTGAATATGCGA ATATTCTTCCTTCTTCTACTACTCCAACTAATCCCTATAGTTTGAATACAATAGATGAACATCTGGATATGTTAATGGTA TGTCACCATCTTGACTTCAATAATCCTGAGGATATTTCTTTTGCTCAGAGTCGTATTCGTCAGCAAACGATTGGAGCAGA GGATTTCTTGCATGACATGGGGGCTATTTCTATTTTTACTTCTGACTCCCAGGCTATGGGTCGTATAGGGGAAGTAATTT GCCGTACATGGCAAATTGCCTCACGTATGAAAGAAATACGAGGGTTCCTTTCAGAAGACCAAATGACAGGAAATGATAAT TATCGCGTAAGAAGATATATTGCTAAGTATACAATTAATGCTGCTCTTGCACATGGATTATCTCACATAGTTGGTTCTGT TGAAAAGGGGAAATTGGCAGATCTTGTTCTTTGGCGACCTGAATTTTTTGGAACGAAACCTGATATAGTTATAAAAGGAG GAATGATAGCCTATGCACAGATGGGTGATCCTAATGCTTCTATTCCTACTCCAGAACCTTATATTTCTCGTCCTATGTAT GGTGCATTTGGGAATGCAGCTTCTGCGACCTCTTGTTTGTTTATCAGTGAAGCTTCAATCGAAGCTATCAAAGGATATGG ACTTAATAAAATGTTAACTGTTGTAAAAGGTTGTCGTGTGATTTCAAAGAATGACTTGAAGTTGAATAATTATATGCCTT GTATTGATATTGATTCAAAAACATTTGAGGTATCAATAGATGGTGTACTTATTTCCGTAAAGCCGGCAAAAAAACTTCCC TTGGCACAACTGTATAATTTGTTTTAG Protein sequence : MAQINRKLYSSMYGITTGDIVTLGDTNLKIQVEKDYTTYGEECVFGGGKVIRDGMGQASGFCDEEVLDMVITNALIIDYK GIYKADIGIKNGKIKGIGKAGNPHIQPGVSPTLIIGTITEVVSGEGRILTAGAIDTHVHYISPQQADEALASGITTFVGG GTGPATGTYATTCTPGWYLRKMMEATDNIPINFGFLGKGNSSKSKALEGQIKAGALGLKLHEDWGSTPSVIDTSLKVADE YDVQICIHTDSINECGYIEDTLCAIDGRTIHAYHVEGAGGGHAPDIMKACEYANILPSSTTPTNPYSLNTIDEHLDMLMV CHHLDFNNPEDISFAQSRIRQQTIGAEDFLHDMGAISIFTSDSQAMGRIGEVICRTWQIASRMKEIRGFLSEDQMTGNDN YRVRRYIAKYTINAALAHGLSHIVGSVEKGKLADLVLWRPEFFGTKPDIVIKGGMIAYAQMGDPNASIPTPEPYISRPMY GAFGNAASATSCLFISEASIEAIKGYGLNKMLTVVKGCRVISKNDLKLNNYMPCIDIDSKTFEVSIDGVLISVKPAKKLP LAQLYNLF |
| Gene | GenBank Accn | Product | Virulance or Resistance | PAI or REI | Alignment Type | E-val | Identity |
| ureC | NP_286680.1 | urease subunit alpha | Virulence | TAI | Protein | 4e-149 | 60 |
| ureC | NP_287088.1 | urease subunit alpha | Not tested | TAI | Protein | 4e-149 | 60 |
| ureC | YP_005684266.1 | Urease alpha subunit | Not tested | PiCp 7 | Protein | 2e-136 | 55 |
| ureC | YP_005682174.1 | Urease alpha subunit | Not tested | PiCp 7 | Protein | 1e-136 | 55 |
| ureC | YP_003784325.1 | urease subunit alpha | Not tested | PiCp 7 | Protein | 1e-136 | 55 |
| ureC | YP_005686358.1 | Urease alpha subunit | Not tested | PiCp 7 | Protein | 1e-136 | 55 |
| Gene | GenBank Accn | Product | ID of source DB | Alignment Type | E-val | Identity |
| ureC | YP_002308901.1 | urease subunit alpha | VFG0270 | Protein | 2e-139 | 56 |
