Gene Information

Name : cagA (HPP12_0555)
Accession : YP_002301189.1
Strain : Helicobacter pylori P12
Genome accession: NC_011498
Putative virulence/resistance : Virulence
Product : cytotoxin-associated protein A
Function : -
COG functional category : -
COG ID : -
EC number : -
Position : 585581 - 589225 bp
Length : 3645 bp
Strand : +
Note : -

DNA sequence : 
ATGACTAACGAAACCATTAACCAACAACCACAAACCGAAGCGGCTTTTAACCCGCAGCAATTTATCAATAATCTTCAAGT
GGCTTTTCTTAAAGTTAATAACGCTGTCGCTTCATACGATCCTGATCAAAAACCAATCGTTGATAAGAACGATAGGGATA
ACAGGCAAGCTTTTGATGGAATCTCGCAATTAAAGGAAGAATACTCCAATAAAGCGATCAAAAATCCTACCAAAAAGAAT
CAGTATTTTTCAGACTTTATCAATAAGAGCAACGATTTAATCAACAAAGACAATCTCATTGATGTAGAATCTTCCACAAA
GAGCTTTCAGAAATTTGGGGATCAGCGTTACCAAATTTTCACAAGTTGGGTGTCCCATCAAAACGATCCGTCTAAAATCA
ACACCCGATCGATCCGAAATTTTATGGAAAATATCATACAACCCCCTATCCCTGATGATAAAGAAAAAGCAGAGTTTTTG
AAATCTGCCAAACAATCTTTTGCAGGAATTATCATAGGGAATCAAATCCGAACGGATCAAAAGTTCATGGGCGTGTTTGA
TGAATCCTTGAAAGAAAGGCAAGAAGCAGAAAAAAATGGAGAGCCTACTGGTGGGGATTGGTTGGATATTTTTTTATCAT
TTATATTTGACAAAAAACAGTCTTCTGATGTCAAAGAAGCAATCAATCAAGAACCAGTTCCTCATGTCCAACCAGATATA
GCCACTACCACCACCGACATACAAGGCTTACCGCCTGAAGCTAGAGATTTACTTGATGAAAGGGGTAATTTTTCTAAATT
CACTCTTGGCGATATGGAAATGTTAGATGTTGAGGGCGTCGCCGACATTGATCCTAATTACAAGTTCAACCAATTATTGA
TTCACAATAACACTCTGTCTTCTGTGTTAATGGGGAGTCATGATGGCATAGAACCTGAAAAAGTTTCATTATTGTATGCG
GGCAATGGTGGTTTTGGAGCCAAGCACGATTGGAACGCCACCGTTGGTTATAAAGACCAACAAGGTAACAATGTGGCTAC
AATAATTAATGTGCATATGAAAAACGGCAGTGGCTTAGTCATAGCAGGTGGTGAGAAAGGGATTAATAACCCTAGTTTTT
ATCTCTACAAAGAAGACCAACTCACAGGCTCACAACGAGCATTGAGTCAAGAAGAGATCCGAAACAAAATAGATTTCATG
GAACTTCTTGCACAAAACAATGCTAAATTAGACAACTTGAGCGAGAAAGAGAAAGAAAAATTCCAAAATGAGATTAAGGA
TTTCCAAAAAGACTCTAAGGCTTATTTAGACGCCCTAGGGAATGATCGTATTGCTTTTGTTTCTAAAAAAGACACAAAAC
ATTCAGCTTTAATTACTGAGTTTGGTAATGGGGATTTGAGCTACACTCTCAAAGATTATGGGAAAAAAGCAGATAAAGCT
TTAGATAGGGAGAAAAATGTTACTCTTCAAGGTAGCCTAAAACATGATGGCGTGATGTTTGTTGATTATTCTAATTTCAA
ATACACCAACGCCTCCAAGAATCCCAATAAGGGTGTAGGCGTTACGAATGGCGTTTCCCATTTAGAAGCAGGCTTTGACA
AGGTAGCTGTCTTTAATTTGCCTGATTTAAATAATCTCGCTATCACTAGTTTCGTAAGGCGGAATTTAGAGGATAAACTA
GTCACTAAAGGATTGTCCATACAAGAAGCTAATAAGCTTATCAAAGACTTTTTGAATAGCAACAAAGAATTGGTTGGAAA
AGCTTTAAACTTCAATAAAGCTGTAGCTGACGCTAAAAACACAGGCAACTATGATGAAGTGAAAAAAGCTCAGAAAGATC
TTGAAAAATCTCTAAAGAAACGAGAGCATTTAGAGAAAGAAGTAGCGAAAAATTTGGAGAGCAAAAGTGGCAACAAAAAC
AAAATGGAAGCGAAATCTCAAGCTAACAGCCAAAAAGATGAGATTTTTGCGTTGATCAATAAAGAGGCTAATAGGGACGC
AAGAGCAATCGCTTACGCTCAGAATCTTAAAGGCATCAAAATGGAATTGTCTGATAAACTTGAAAATGTCAACAAGAATT
TGAAAGACTTTAGTAAATCTTTTGATGAATTCAAAAATGGCAAAAATAAGGATTTCAGCAAGGCAGAAGAAACACTAAAA
GCCCTTAAAGGTTCGGTGAAAGATTTAGGTATCAATCCAGAATGGATTTCAAAAGTTGAAAACCTTAATGCAGCTTTGAA
TGAATTCAAAAATGGCAAAAATAAGGATTTCAGCAAGGTAGCGCAAGCAAAAAGCGACCTTGAAAATTCCGTTAAAGATG
TGATCATCAATCAAAAGATAACGGATAAAGTTGATAATCTCAATCAAGCGGTATCAGTGGCTAAAGCAACGGGTGATTTC
AGTAGGGTAGAGCAAGCGTTAGCCGATCTCAAAAACTTCTCAAAGGAGCAATTGGCTCAACAAGCTCAAAAAAATGAAGA
TTTCAATACTGGAAAAAATTCTGCACTATACCAATCCGTTAAGAATGGTGTGAATGGAACCCTAGTCGGTAATGGGTTAT
CTAAAGCAGAAGCCACAACTCTTTCTAAAAACTTTTCGGACATCAAGAAAGAGTTGAATGCAAAACTTGGAAATTTCAAT
AACAATAACAATAATGGACTCAAAAACGAACCCATTTATGCTAAAGTTAATAAAAAGAAAACAGGGCAAGCAGCTAGCCA
TGAAGAACCCATTTACGCTCAAGTTGCTAAAAAGGTAAATGCAAAAATTGACCGACTCAATCAAATAGCAAGTGGTTTGG
GTGGTGTAGGGCAAGCAGCGGGCTTCCCTTTGAAAAAGCATGATAAAGTTGAAGATCTCAGTAAGGTAGGGCTTTCAGCT
AGCCCTGAACCCATTTATGCTACGATTGATGATCTCGGCGGACCTTTCCCTTTGAAAAAGCATGATAAAGTTGAAGATCT
CAGTAAGGTAGGGCTTTCAGCTAGCCCTGAACCCATTTATGCTACGATTGATGATCTCGGCGGACCTTTCCCTTTGAAAA
AGCATGATAAAGTTGAAGATCTCAGTAAGGTAGGGCTTTCAAGGAATCAAAAATTGGCTCAGAAAATTGACAATCTCAAT
CAAGCGGTATCAGAAGCTAAAGCAGGTTTTTTTGGCAATCTAGAGCAAACGATAGACAAGCTCAAAGATTCTACAAAATA
CAATCCTGTGAATCTATGGGTTGAAAGTGCAAAAAAAGTACCTGCTAGTTTGTCAGCGAAACTAGATAATTATGCTACTA
ACAGCCACACACGCATTAATAGCAATATCAAAAATGGAGCAATCAATGAAAAAGCGACCGGCATGCTAGCGCAAAAAAAC
CCTGAGTGGCTCAAGCTCGTGAATGATAAGATAGTTGCGCATAATGTGGGAAGCGTTCCTTTGTTAGAGTATGATAAAAT
TGGCTTCAACCAGAAGAATATGAAAGATTATTCTGATTCGTTCAAGTTTTCCACCAACTTGAACAATGCTGTAAAAGACA
TTAAGTCTGGCTTTACGCAATTTTTAGCCAATGCATTTTCTACAGGATATTACTGCTTGGCGAGGGAAAATGCAGAGCAT
GGAATCAAGAATGTTAATACAAAAGGTGGTTTCCAAAAATCTTAA

Protein sequence : 
MTNETINQQPQTEAAFNPQQFINNLQVAFLKVNNAVASYDPDQKPIVDKNDRDNRQAFDGISQLKEEYSNKAIKNPTKKN
QYFSDFINKSNDLINKDNLIDVESSTKSFQKFGDQRYQIFTSWVSHQNDPSKINTRSIRNFMENIIQPPIPDDKEKAEFL
KSAKQSFAGIIIGNQIRTDQKFMGVFDESLKERQEAEKNGEPTGGDWLDIFLSFIFDKKQSSDVKEAINQEPVPHVQPDI
ATTTTDIQGLPPEARDLLDERGNFSKFTLGDMEMLDVEGVADIDPNYKFNQLLIHNNTLSSVLMGSHDGIEPEKVSLLYA
GNGGFGAKHDWNATVGYKDQQGNNVATIINVHMKNGSGLVIAGGEKGINNPSFYLYKEDQLTGSQRALSQEEIRNKIDFM
ELLAQNNAKLDNLSEKEKEKFQNEIKDFQKDSKAYLDALGNDRIAFVSKKDTKHSALITEFGNGDLSYTLKDYGKKADKA
LDREKNVTLQGSLKHDGVMFVDYSNFKYTNASKNPNKGVGVTNGVSHLEAGFDKVAVFNLPDLNNLAITSFVRRNLEDKL
VTKGLSIQEANKLIKDFLNSNKELVGKALNFNKAVADAKNTGNYDEVKKAQKDLEKSLKKREHLEKEVAKNLESKSGNKN
KMEAKSQANSQKDEIFALINKEANRDARAIAYAQNLKGIKMELSDKLENVNKNLKDFSKSFDEFKNGKNKDFSKAEETLK
ALKGSVKDLGINPEWISKVENLNAALNEFKNGKNKDFSKVAQAKSDLENSVKDVIINQKITDKVDNLNQAVSVAKATGDF
SRVEQALADLKNFSKEQLAQQAQKNEDFNTGKNSALYQSVKNGVNGTLVGNGLSKAEATTLSKNFSDIKKELNAKLGNFN
NNNNNGLKNEPIYAKVNKKKTGQAASHEEPIYAQVAKKVNAKIDRLNQIASGLGGVGQAAGFPLKKHDKVEDLSKVGLSA
SPEPIYATIDDLGGPFPLKKHDKVEDLSKVGLSASPEPIYATIDDLGGPFPLKKHDKVEDLSKVGLSRNQKLAQKIDNLN
QAVSEAKAGFFGNLEQTIDKLKDSTKYNPVNLWVESAKKVPASLSAKLDNYATNSHTRINSNIKNGAINEKATGMLAQKN
PEWLKLVNDKIVAHNVGSVPLLEYDKIGFNQKNMKDYSDSFKFSTNLNNAVKDIKSGFTQFLANAFSTGYYCLARENAEH
GIKNVNTKGGFQKS

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
cagA AAC44706.1 CagA Virulence cag PAI Protein 0.0 96
cagA AAR03881.1 CagA Virulence cag PAI Protein 0.0 93
cagA BAD51747.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 93
cagA BAC10428.1 CagA Virulence cag PAI Protein 0.0 92
HP0547 BAD13908.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 92
HP0547 BAD14045.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 91
cagA AAR03970.1 CagA Virulence cag PAI Protein 0.0 91
cagA AAF17598.1 CagA Virulence cag PAI Protein 0.0 91
cagA AAR03909.1 CagA Virulence cag PAI Protein 0.0 90
HP0547 NP_207343.1 cag pathogenicity island protein (cag26) Virulence cag PAI Protein 0.0 90
cagA AAR03939.1 CagA Virulence cag PAI Protein 0.0 87
cagA BAD51759.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 86
HP0547 BAD13935.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 85
cagA BAC10429.1 CagA Virulence cag PAI Protein 0.0 85
cagA NP_223213.1 cag island protein, cytotoxicity associated immunodominant antigen Virulence cag PAI Protein 0.0 84
cagA BAD51760.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 84
cagA BAD51758.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 84
cagA BAD51750.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 84
cagA BAC10432.1 CagA Virulence cag PAI Protein 0.0 84
HP0547 BAD13990.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 84
cagA BAD51751.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 83
cagA BAD51756.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 82
cagA BAD51753.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 82
cagA YP_003728762.1 cytotoxin-associated protein A Virulence cag PAI Protein 0.0 82
cagA BAD51752.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 82
cagA AGC69806.1 cag pathogenicity island protein A Virulence cag PAI Protein 0.0 82
cagA BAD51766.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 82
cagA BAD51761.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 82
cagA BAD51764.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 79
cagA YP_005774524.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 77
cagA BAC10419.1 CagA Virulence cag PAI Protein 0.0 77
cagA BAD51754.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 77
cagA YP_005777288.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 76
cagA BAC10426.1 CagA Virulence cag PAI Protein 0.0 76
cagA YP_005779046.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 76
cagA BAC10421.1 CagA Virulence cag PAI Protein 0.0 76
cagA BAC10431.1 CagA Virulence cag PAI Protein 0.0 76
HP0547 BAD13799.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 76
HP0547 BAD13963.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 76
cagA BAD51755.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 76
cagA BAD51749.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 76
cagA BAC10435.1 CagA Virulence cag PAI Protein 0.0 76
HP0547 BAD14072.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 76
cagA BAC10420.1 CagA Virulence cag PAI Protein 0.0 76
cagA YP_005775747.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 76
cagA BAD51762.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 76
HP0547 BAD13880.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 76
cagA AAF17597.1 CagA Virulence cag PAI Protein 0.0 76
cagA BAC10433.1 CagA Virulence cag PAI Protein 0.0 75
HP0547 BAD14018.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 75
cagA BAD51744.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 75
HP0547 BAD13853.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 75
cagA BAC10423.1 CagA Virulence cag PAI Protein 0.0 75
cagA BAC10427.1 CagA Virulence cag PAI Protein 0.0 74
cagA BAC10424.1 CagA Virulence cag PAI Protein 0.0 74
cagA BAC10430.1 CagA Virulence cag PAI Protein 0.0 74
cagA BAC10422.1 CagA Virulence cag PAI Protein 0.0 66
HP0547 BAD13826.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 66

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
cagA YP_002301189.1 cytotoxin-associated protein A VFG0306 Protein 0.0 90