Gene Information

Name : clpB (HPP12_0263)
Accession : YP_002300901.1
Strain : Helicobacter pylori P12
Genome accession: NC_011498
Putative virulence/resistance : Virulence
Product : ATP-dependent protease binding subunit
Function : -
COG functional category : O : Posttranslational modification, protein turnover, chaperones
COG ID : COG0542
EC number : -
Position : 269483 - 272053 bp
Length : 2571 bp
Strand : +
Note : heat shock protein

DNA sequence :
ATGAATTTATTTGAAAAGATGACTGACCAATTGCATGAGACTTTAGACAGCGCGCTCGCTTTAGCCTTACACCACAAAAA
CGCTGAAGTAACGCCCTTGCACATGCTTTTTGCCATGCTCAATAACTCCCAAGGCATTCTTATTCAAGCCTTACAAAAAA
TGCCTGTGGATATTCAAGCTTTAAGGCTTAGCGTTCAAAGCGAGCTGAATAAGTTCGCTAAAGTTTCACAAATCAACAAG
CAAAATATCCAATTAAACCAAGCTCTAATCCAAAGTTTAGAAAACGCTCAAGGCTTGATGGCTAAAACGGGCGATTCTTT
CATCGCTACCGATGTGTATCTTTTGGCGAATATGAGCCTTTTTGAAAGCGTTCTAAAGCCTTATTTAGACACTAAGGAAT
TGCAAAAAACTTTAGAATCTTTAAGAAAAGGCACGACTATCCAAGGTAAAAACGATGATTCTAATTTGGAAAGTTTAGAA
AAATTTGGCATTGATTTGACGCAAAAAGCTTTAGACAATAAGCTGGATCCTGTGATCGGAAGGGATGAAGAAATCATTCG
CATGATGCAAATTTTGATAAGAAAAACAAAAAATAACCCTATTTTACTAGGTGAGCCTGGAGTGGGGAAAACGGCGGTTG
TGGAAGGGTTAGCCCAACGCATTGTGAATAAGGAAGTGCCTAAAACGCTCTTAAACAAACGAGTCGTCGCTTTAGATTTA
AGCTTATTGGTGGCTGGAGCGAAATACAGAGGCGAGTTTGAAGAGCGCTTGAAAAAGGTGATTGAAGAAGTTAAAAAAAG
CGCGAATGTGATTTTATTCATTGATGAAATCCACACGATTGTGGGGGCTGGGGCTAGTGAGGGGGGCATGGATGCGGCTA
ATATTTTAAAACCCGCGCTCGCTAGGGGGGAATTGCACACGATTGGAGCGACCACTTTAAAAGAATACCGCAAGTATTTT
GAAAAAGACATGGCACTACAAAGGCGTTTCCAACCCATTTTACTCAATGAGCCTAGCATCAATGAAGCTTTACAGATTTT
AAGGGGGTTGAAAGAAACTTTAGAAACGCACCATAATATCACCATCAATGACTCCGCGCTCATAGCGAGCGCTAAACTCT
CTAGCCGTTATATCACCGATAGGTTTTTACCCGATAAGGCGATTGATTTGATTGATGAGGGGGCGGCTCAATTAAAAATG
CAAATGGAATCAGAGCCGGCAAAACTCTCTAGCGTTAAGCGCTCCATTCAAAGACTAGAAATGGAAAAACAAGCCCTTGA
AATGGAAAAAAAGGAAAGCAACCATAAACGCATGCAAGAAATCCTTAAAGAATTGAGCGATTTGAAAGAAGAAAAAATCC
AATTAGAAGCACAATTTGAAAACGAAAAAGAAGTGTTCAAAGAAATTTCACGCTTGAAAATGGAAATGGAAAGCTTGAAA
AAAGAGGCTGAGAGGTTTAAACGCAATGGGGATTTCCAGCAAGCGGCTGAAATTGAATATTCTAAAATCCCTGAAAATAA
AAAGAAAGAAGAAGAATTGCAGCACAAATGGGAAACGATGCAACAAAATGGGGCGTTGTTGCAAAACGCTTTAACCGAAA
ACAACATCGCTGAGATCGTGAGCCAATGGACGCACATCCCGGTCCAAAAAATGCTCCAAAGCGAAAAAAATAGGGTTTTA
AACATTGAAAGCGAATTGCAAAAAAGGGTGGTGGGGCAAGAAAAAGCGATCAAAGCGATCGCTAAAGCGATTAAAAGGAA
TAAGGCCGGCCTTAGCGATAGCAATAAACCTATAGGGAGTTTCCTCTTTTTAGGGCCAACAGGGGTGGGAAAAACTGAGA
GCGCTAAAGCTTTGGCGCAATTCTTGTTTGATAGCGATAAAAATCTTATAAGAATTGACATGAGCGAATACCTAGAAAAG
CACGCCATAAGCCGTCTTATTGGGGCCGCTCCTGGGTATGTGGGCTATGAAGAAGGCGGGCAATTGACCGAAGCGGTGCG
CAGAAAGCCTTATAGCGTGGTGTTGTTAGATGAAGTGGAAAAAGCCCATCCGGATGTGTTTAACCTCTTGTTGCAGGTTT
TAGATGAAGGGCATTTAACCGATAGTAAGGGCGTGAGGGTGGATTTCAAAAACACGATTTTGATTTTAACCAGCAATGTG
GCTAGCGGCGCGCTTTTAGAAGAAAGTTTGAGCGAAGCCGATAAACAAAAAGCGATTAAAGAGAGCTTGAGGCAATTTTT
CAAGCCGGAATTTTTAAACCGCCTAGATGAAATCATCTCCTTTAACGCCCTAGATAGTCATGCTATCATTAATATCGTGG
GGATACTCTTTGAAAACATTCAAAAAAAAGCGCTTGAAAGGGGCATTAATATAACCTTAGACGAAAAGGCAAAAGAATTG
ATCGCCGAAGCGGGATTTGACAGATTCTATGGCGCTAGACCCTTAAAACGCGCGCTCTATGAAATGGTAGAAGACAAGCT
CGCTGAACTCATTTTAGAGGATAAAGTTAAAGAGAATGACAGCGTGGCGTTTGTGGTAGAAAATAACGAGATTGTGCCTA
AGATTAAGTGA

Protein sequence :
MNLFEKMTDQLHETLDSALALALHHKNAEVTPLHMLFAMLNNSQGILIQALQKMPVDIQALRLSVQSELNKFAKVSQINK
QNIQLNQALIQSLENAQGLMAKTGDSFIATDVYLLANMSLFESVLKPYLDTKELQKTLESLRKGTTIQGKNDDSNLESLE
KFGIDLTQKALDNKLDPVIGRDEEIIRMMQILIRKTKNNPILLGEPGVGKTAVVEGLAQRIVNKEVPKTLLNKRVVALDL
SLLVAGAKYRGEFEERLKKVIEEVKKSANVILFIDEIHTIVGAGASEGGMDAANILKPALARGELHTIGATTLKEYRKYF
EKDMALQRRFQPILLNEPSINEALQILRGLKETLETHHNITINDSALIASAKLSSRYITDRFLPDKAIDLIDEGAAQLKM
QMESEPAKLSSVKRSIQRLEMEKQALEMEKKESNHKRMQEILKELSDLKEEKIQLEAQFENEKEVFKEISRLKMEMESLK
KEAERFKRNGDFQQAAEIEYSKIPENKKKEEELQHKWETMQQNGALLQNALTENNIAEIVSQWTHIPVQKMLQSEKNRVL
NIESELQKRVVGQEKAIKAIAKAIKRNKAGLSDSNKPIGSFLFLGPTGVGKTESAKALAQFLFDSDKNLIRIDMSEYLEK
HAISRLIGAAPGYVGYEEGGQLTEAVRRKPYSVVLLDEVEKAHPDVFNLLLQVLDEGHLTDSKGVRVDFKNTILILTSNV
ASGALLEESLSEADKQKAIKESLRQFFKPEFLNRLDEIISFNALDSHAIINIVGILFENIQKKALERGINITLDEKAKEL
IAEAGFDRFYGARPLKRALYEMVEDKLAELILEDKVKENDSVAFVVENNEIVPKIK

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
STY0294 NP_454876.1 ClpB-like protein Not tested SPI-6 Protein 2e-97 41

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
clpB YP_002300901.1 ATP-dependent protease binding subunit VFG0079 Protein 2e-153 42
clpB YP_002300901.1 ATP-dependent protease binding subunit VFG2076 Protein 3e-111 41