Gene Information

Name : fliI (HPP12_1393)
Accession : YP_002302021.1
Strain : Helicobacter pylori P12
Genome accession: NC_011498
Putative virulence/resistance : Virulence
Product : flagellum-specific ATP synthase
Function : -
COG functional category : N : Cell motility
COG ID : COG1157
EC number : -
Position : 1472901 - 1474205 bp
Length : 1305 bp
Strand : -
Note : involved in type III protein export during flagellum assembly

DNA sequence :
ATGCCCCTAAAATCCTTAAAAAACCGCTTGAATCAGCATTTTGATCTATCGCCTCGCTACGGGAGCGTGAAAAAAATCAT
GCCCAATATCGTTTATGCGGATGGTTTTAACCCGTCTGTGGGCGATGTGGTGAAGATTGAAAAAAGCGATGGCAGCGAAT
GCGTGGGAATGGTGGTGGTGGCAGAAAAAGAGCAGTTTGGTTTCACGCCCTTTAACTTCATAGAGGGGGCTAGGGCTGGC
GATAAGGTGCTGTTTTTAAAAGAGGGGTTGAATTTCCCTGTGGGCCGTAATCTTTTAGGGAGGGTGCTTAACCCTTTAGG
GCAAGTCATTGACAATAAGGGGGTGCTAGATTATGAGCGATTAGCGCCTGTCATTACAACGCCTATAGCCCCTTTAAAAA
GAGGCTTGATTGATGAGGTTTTTAGCGTGGGGGTGAAGAGCATTGATGGGCTTTTGACTTGCGGTAAGGGGCAAAAACTG
GGCATTTTTGCCGGCTCTGGGGTGGGTAAATCCACGCTAATGGGCATGATCACTAGGGGTTGCTTAGCGCCCATTAAAGT
GATTGCTTTGATTGGGGAAAGGGGCAGAGAAATCCCTGAATTTATAGAGAAAAACCTGAAAGGGGATTTAAGCTCTTGCG
TGTTGGTGGTCGCTACGAGCGATGATAGCCCTTTGATGCGCAAATACGGGGCCTTTTGTGCGATGAGCGTGGCGGAGTAT
TTTAAAAACCAAGGGCTAGATGTGTTGTTTATCATGGATTCAGTGACTCGTTTCGCTATGGCTCAAAGAGAAATCGGTTT
AGCCTTAGGCGAACCGCCCACTTCCAAAGGCTACCCCCCATCCGCGCTTTCCTTATTGCCTCAATTAATGGAGAGAGCGG
GTAAGGAAGAAAATAAGGGGAGCATTACGGCTTTTTTTAGCGTGCTAGTAGAGGGCGATGATTTGAGCGATCCCATAGCC
GATCAGGCCAGGAGTATTTTAGATGGGCATATCGTCTTAAGCAGGGAATTAACCGATTATGGGATCTACCCGCCTATTAA
TATTTTAAACTCCGCATCAAGGGTGGCTAAAGACATCATCAGCGAGTCTCAAAACCTTTATGCGAGAAAATTCCGCCGTT
TGTATGCGTTATTGAAAGAAAATGAAATGCTCATTCGCATCGGCTCTTATCAAATGGGGAACGATAAAGAGCTTGATGAA
GCGATTAAGAAAAAGGCTTTAATGGAGCAATTTTTAGTGCAAGATGAAAACGCTTTGCAGCCTTTTGAACAAAGCTTTCA
GCAATTAGAAGAAATCTTAAGATAA

Protein sequence :
MPLKSLKNRLNQHFDLSPRYGSVKKIMPNIVYADGFNPSVGDVVKIEKSDGSECVGMVVVAEKEQFGFTPFNFIEGARAG
DKVLFLKEGLNFPVGRNLLGRVLNPLGQVIDNKGVLDYERLAPVITTPIAPLKRGLIDEVFSVGVKSIDGLLTCGKGQKL
GIFAGSGVGKSTLMGMITRGCLAPIKVIALIGERGREIPEFIEKNLKGDLSSCVLVVATSDDSPLMRKYGAFCAMSVAEY
FKNQGLDVLFIMDSVTRFAMAQREIGLALGEPPTSKGYPPSALSLLPQLMERAGKEENKGSITAFFSVLVEGDDLSDPIA
DQARSILDGHIVLSRELTDYGIYPPINILNSASRVAKDIISESQNLYARKFRRLYALLKENEMLIRIGSYQMGNDKELDE
AIKKKALMEQFLVQDENALQPFEQSFQQLEEILR

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
lscN AAO18044.1 LscN Virulence TTSS locus Protein 3e-73 50
escN CAC81862.1 EscN protein Virulence LEE II Protein 2e-76 46
escN AAC38383.1 EscN Virulence LEE Protein 5e-78 46
ECs4568 NP_312595.1 EscN Virulence LEE Protein 2e-77 46
escN AAC31513.1 L0034 Virulence LEE Protein 1e-77 46
unnamed ACU09458.1 type III secretion apparatus H+-transporting two-sector ATPase Virulence LEE Protein 1e-77 46
escN NP_290268.1 hypothetical protein Virulence LEE Protein 2e-77 46
unnamed AAL06369.1 EscN Virulence LEE Protein 3e-76 45
escN AAK26715.1 EscN Virulence LEE Protein 5e-76 45
escN AAL57542.1 EscN Virulence LEE Protein 5e-76 45
escN YP_003232153.1 T3SS structure protein EscN Virulence LEE Protein 3e-76 45
hrcN AAT96141.1 HrcN Virulence T-PAI Protein 6e-54 45
hrcN AAT96195.1 HrcN Virulence T-PAI Protein 7e-54 45
hrcN AAP34339.1 HrcN Virulence Hrp PAI Protein 3e-81 44
hrcN NP_640767.1 type III secretion system ATPase Virulence Hrp PAI Protein 3e-80 44
hrpB6 AAB08461.1 HrpB6 Virulence Hrp PAI Protein 4e-79 44
hrcN YP_362163.1 type III secretion system ATPase Virulence Hrp PAI Protein 5e-79 44
hrpB6 BAB07852.1 HrpB6 Virulence Hrp PAI Protein 2e-80 44
hrpB6 AAF61281.1 HrpB6 Virulence Hrp PAI Protein 2e-80 44
hrcN YP_198730.1 type III secretion system ATPase Virulence Hrp PAI Protein 2e-80 44
escN AFO66300.1 putative LEE-encoded type III secretion system ATPase Virulence SESS LEE Protein 3e-69 44
escN AFO66415.1 putative LEE-encoded type III secretion system ATPase Virulence SESS LEE Protein 3e-69 44
hrcN AAG33879.1 HrcN Virulence Hrp PAI Protein 8e-53 44
hrcN NP_791227.1 type III secretion cytoplasmic ATPase HrcN Virulence Hrp PAI Protein 6e-53 44
XC_3006 YP_244074.1 type III secretion system ATPase Virulence Hrp PAI Protein 2e-79 43
hrcN NP_636610.1 type III secretion system ATPase Virulence Hrp PAI Protein 2e-79 43
ysaN AAS66842.1 YsaN Not tested SSR-1 Protein 2e-58 43
escN YP_003236088.1 translocator EscN Virulence LEE Protein 3e-77 42
escN CAI43874.1 EscN protein Virulence LEE Protein 2e-76 42
escN YP_003223475.1 translocator EscN Virulence LEE Protein 2e-76 42
hrcN AAT96258.1 HrcN Virulence S-PAI Protein 5e-58 42
hrcN AAT96299.1 HrcN Virulence S-PAI Protein 2e-58 42
hrcN AAT96339.1 HrcN Virulence S-PAI Protein 7e-59 42
YPO0267 YP_002345348.1 type III secretion system ATPase Virulence Not named Protein 2e-72 41
invC AAS66861.1 InvC Not tested SSR-2 Protein 3e-59 41
ECs3730 NP_311757.1 ATP synthase SpaL Not tested LIM Protein 6e-53 41

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
fliI YP_002302021.1 flagellum-specific ATP synthase VFG0390 Protein 4e-80 52
fliI YP_002302021.1 flagellum-specific ATP synthase VFG0192 Protein 2e-76 51
fliI YP_002302021.1 flagellum-specific ATP synthase VFG0048 Protein 2e-78 50
fliI YP_002302021.1 flagellum-specific ATP synthase VFG2144 Protein 5e-77 47
fliI YP_002302021.1 flagellum-specific ATP synthase VFG0730 Protein 3e-78 46
fliI YP_002302021.1 flagellum-specific ATP synthase VFG0812 Protein 8e-78 46
fliI YP_002302021.1 flagellum-specific ATP synthase VFG1254 Protein 9e-77 45
fliI YP_002302021.1 flagellum-specific ATP synthase VFG1778 Protein 3e-55 43
fliI YP_002302021.1 flagellum-specific ATP synthase VFG2331 Protein 6e-71 42
fliI YP_002302021.1 flagellum-specific ATP synthase VFG1008 Protein 3e-60 41