Gene Information

Name : metB (HPP12_0108)
Accession : YP_002300748.1
Strain : Helicobacter pylori P12
Genome accession: NC_011498
Putative virulence/resistance : Resistance
Product : cystathionine gamma-synthase/cystathionine beta-lyase
Function : -
COG functional category : E : Amino acid transport and metabolism
COG ID : COG0626
EC number : -
Position : 112372 - 113514 bp
Length : 1143 bp
Strand : -
Note : catalyzes the formation of L-cystathionine from O-succinyl-L-homoserine and L-cysteine; or Cystathionine beta-lyase (CBL) can convert cystathionine to homocysteine

DNA sequence :
ATGCGCATGCAAACCAAATTAATCCATGGGGGCATTAGTGAGGACGCGACAACGGGGGCAGTGAGCGTGCCTATTTATCA
AACTTCCACCTACCGCCAAGACGCCATAGGCCGCCACAAGGGCTATGAATACTCTCGCTCAGGAAACCCCACGCGCTTTG
CTTTAGAAGAACTCATCGCCGATTTAGAAGGGGGGGTCAAGGGGTTTGCTTTTGCCTCTGGACTAGCTGGGATCCACGCC
GTTTTTTCCCTCTTGCAATCAGGCGATCATGTGTTATTGGGCGATGATGTTTATGGGGGGACTTTCCGCTTGTTTAATAA
AGTGCTTGTCAAAAACGGGCTTTCTTGCACCATTATCGACACTAGCGATATATCCCAAATCAAAAAGGCTATCAAGCAAA
ACACCAAAGCCCTTTATTTAGAAACCCCTAGTAACCCCTTGCTTAAAATCACGGATTTAGCGCAATGCGCTAGTGTCGCT
AAAGATCATAATTTGCTCACTATCGTGGATAACACTTTTGCCACCCCCTATTATCAAAACCCGCTTCTTTTGGGGGCGGA
CATTGTAGTGCATAGCGGCACAAAATACTTAGGCGGGCATAGCGATGTAGTCGCTGGGCTTGTAACCACTAATAATGAAG
CGTTAGCCCAAGAGATCGCTTTTTTCCAAAACGCTATCGGTGGGGTTTTAGGCCCTCAAGACAGCTGGCTGTTGCAAAGA
GGGATTAAAACGCTGGGATTGCGCATGGAGGCCCATCAAAAAAACGCCCTTTGCGTGGCTGAATTTTTAGAAAAACACCC
TAAAGTAGAAAGGGTTTATTACCCGGGCCTGCCCACTCACCCTAATTACGAGCTAGCCAAAGCCCAAATGCGTGGCTTTA
GCGGGATGCTCTCTTTTACCCTCAAAAATGACAGCGAGGCGACTCTTTTTGTAGAAAGCCTTAAATTATTCATTTTAGGC
GAGAGTTTGGGCGGGGTGGAAAGTTTGGTGGGGATTCCGGCATTTATGACCCATGCGTGTATCCCTAAAGAACAACGAGA
AGCTGCAGGGATTAGGGATGGCTTGGTGCGCTTGTCTGTGGGGATTGAGCATGAACAGGATTTGTTAGAAGATTTAGAGC
AAGCGTTCGCTAAAATAAGCTAA

Protein sequence :
MRMQTKLIHGGISEDATTGAVSVPIYQTSTYRQDAIGRHKGYEYSRSGNPTRFALEELIADLEGGVKGFAFASGLAGIHA
VFSLLQSGDHVLLGDDVYGGTFRLFNKVLVKNGLSCTIIDTSDISQIKKAIKQNTKALYLETPSNPLLKITDLAQCASVA
KDHNLLTIVDNTFATPYYQNPLLLGADIVVHSGTKYLGGHSDVVAGLVTTNNEALAQEIAFFQNAIGGVLGPQDSWLLQR
GIKTLGLRMEAHQKNALCVAEFLEKHPKVERVYYPGLPTHPNYELAKAQMRGFSGMLSFTLKNDSEATLFVESLKLFILG
ESLGGVESLVGIPAFMTHACIPKEQREAAGIRDGLVRLSVGIEHEQDLLEDLEQAFAKIS

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
SAR0460 YP_039909.1 Cys/Met metabolism PLP-dependent enzyme Not tested vSa¥á Protein 5e-97 54
SAS0418 YP_042545.1 Cys/Met metabolism PLP-dependent enzyme Not tested vSa¥á Protein 4e-98 54
metB YP_281510.1 cystathionine beta-lyase Not tested Not named Protein 9e-72 47

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
metB YP_002300748.1 cystathionine gamma-synthase/cystathionine beta-lyase BAC0207 Protein 8e-63 43