Gene Information

Name : guaA (OCAR_6467)
Accession : YP_002289445.1
Strain : Oligotropha carboxidovorans OM5; ATCC 49405
Genome accession: NC_011386
Putative virulence/resistance : Unknown
Product : GMP synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0519
EC number : 6.3.5.2
Position : 2404444 - 2406039 bp
Length : 1596 bp
Strand : -
Note : contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway

DNA sequence :
ATGACAGCACCCCGCCAGAGCACGTCCGCGACGCCCGATGTGGCGGCCGCGCACGACAAGATTCTGATCGTCGATTTCGG
CTCTCAGGTCACGCAATTGATCGCCCGCCGCGTCCGGGAAGAGGGCGTCTATTCCGAAATCGTCCCCTTCCAGAAAGCTG
AGCAGGCCTTCACGGCGATGCAGCCGAAAGCCGTGATCCTCTCGGGCGGCCCGGCCTCGGTGCTGGAGGCAGGCGCGCCG
TCCGCGCCGATGTCGATCTTCACCGCGGGTGTGCCGGTGCTCGGCATCTGCTACGGCGAGCAGACCATGGCGCAGCAACT
TGGCGGCATGGTCGAGGGCGGGCACCATCGCGAATTCGGCCGCGCCGCCATCGAGATCACCGACGACTGCGCCCTGTTCG
AGGGCGTCTGGAAGAAGGGCGAGCAGCACGACGTCTGGATGAGCCATGGCGACCGCGTCACGAAGTTGCCCGAAGGCTTC
CGCGGTGTGGCCAGGGCGGCGGGTTCGCCGATCGCGATCATCGCCGACGATACGCGCAAGTTCTACGCGATGCAGTTTCA
CCCCGAGGTGGTGCACACGCCGGACGGCGCCAAACTGATCCGCAATTTCGTGCGCAAGGTCGCAGGCCTGAAGGGCGACT
GGACCATGCGCGCCTTCCGCGAAGAGGCGATCGAGAAGATCCGCGCGCAGGTGGGCCAGGGCCGGGTGATCTGCGGCCTC
TCTGGCGGCGTCGATTCAGCGGTGGCGGCGGTGCTGATCCATGAGGCGATCGGCGATCAACTCACCTGCGTGTTCGTCGA
TCACGGCTTGCTGCGCATGGCCGAAGCCGAGACGGTGGTGAGCCTGTTTCGCGACCACTACAACATTCCGCTCGTGCATG
TGGATGCGTCCAAGACATTCCTGGGGGAGCTTGCGGGCGTCACCGATCCCGAACTGAAGCGCAAGACCATCGGCCGGCTG
TTTATCGATGTGTTCGATGAGGAAGCGAAGAAGATCGGTGGTGCCGATTTCCTCGCGCAGGGCACGCTCTATCCGGACGT
GATCGAAAGCGTGTCGTTCACCGGCGGGCCTTCGGTGACGATCAAGTCGCATCACAATGTCGGCGGCCTGCCCGCGCGCA
TGAAGATGAAGCTCGTCGAGCCGCTGCGCGAGCTGTTCAAGGATGAAGTGCGCGCCTTGGGCCGAGAACTCGGCCTGCCG
GATGTGTTCGTCGGCCGCCATCCGTTTCCGGGACCGGGGCTTGCGATCCGCTGCCCGGGCGAGATCACGCCGGAGAAACT
CGACATCCTGCGGCAGGCGGATGCGATCTATATCGAGGAAATCCGCCGCGCCGGTCTGTACGATACGATCTGGCAGGCGT
TCGCCGTGCTGCTGCCGGTGAAAACCGTCGGGGTGATGGGCGACGGGCGGACTTACGAATTCGTGGTCGGCCTGCGCGCG
GTGACCTCGACCGACGGCATGACGGCGGATTTCTATCCGTTCGACATGAGGTTTCTCGGCGAAACCGCAACCCGCATCAT
CAACGAGGTGAAGGGCGTCAACCGCGTGGTCTACGACGTGACGAGCAAGCCGCCTGGCACGATCGAGTGGGAATAA

Protein sequence :
MTAPRQSTSATPDVAAAHDKILIVDFGSQVTQLIARRVREEGVYSEIVPFQKAEQAFTAMQPKAVILSGGPASVLEAGAP
SAPMSIFTAGVPVLGICYGEQTMAQQLGGMVEGGHHREFGRAAIEITDDCALFEGVWKKGEQHDVWMSHGDRVTKLPEGF
RGVARAAGSPIAIIADDTRKFYAMQFHPEVVHTPDGAKLIRNFVRKVAGLKGDWTMRAFREEAIEKIRAQVGQGRVICGL
SGGVDSAVAAVLIHEAIGDQLTCVFVDHGLLRMAEAETVVSLFRDHYNIPLVHVDASKTFLGELAGVTDPELKRKTIGRL
FIDVFDEEAKKIGGADFLAQGTLYPDVIESVSFTGGPSVTIKSHHNVGGLPARMKMKLVEPLRELFKDEVRALGRELGLP
DVFVGRHPFPGPGLAIRCPGEITPEKLDILRQADAIYIEEIRRAGLYDTIWQAFAVLLPVKTVGVMGDGRTYEFVVGLRA
VTSTDGMTADFYPFDMRFLGETATRIINEVKGVNRVVYDVTSKPPGTIEWE

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
SAPIG0468 YP_005733278.1 GMP synthase [glutamine-hydrolyzing] (Glutamineamidotransferase) (GMP synthetase) Not tested SAPI-S0385 Protein 5e-135 55
SAMSHR1132_03620 YP_005324884.1 GMP synthase Not tested vSa¥á Protein 4e-135 55
guaA YP_001331415.1 GMP synthase Not tested vSa¥á Protein 7e-135 54
guaA NP_938969.1 GMP synthase Not tested Not named Protein 1e-122 52