Gene Information

Name : cadA3 (OCAR_4019)
Accession : YP_002287036.1
Strain : Oligotropha carboxidovorans OM5; ATCC 49405
Genome accession: NC_011386
Putative virulence/resistance : Resistance
Product : cadmium-translocating P-type ATPase
Function : -
COG functional category : P : Inorganic ion transport and metabolism
COG ID : COG2217
EC number : 3.6.3.3
Position : 16014 - 18152 bp
Length : 2139 bp
Strand : -
Note : -

DNA sequence :
ATGGCAACCGCGAGTCCGTTGAAGCTGCGTATCGAAGGGATGGATTGCGGTGCCTGCGCCGCGAAAATCGAGAACGCGAT
GAAGCGGCTGCCGGGTGTCAGCGATATCGACGTCAACTACAGCCTGCAGTCGCTCTCCTTGGCGGTCGACGAAGACCGCA
CATCCCGCGGCACAATCGAGGCCAAGATCAGGGCGCTCGGCTATGCACCTGTGGATCCGTCCGAGCAGGTCATGTCGGCG
GGTCATCGTGATGGGGATCGCGATACGGCGGAAGGTACGTGGTGGTCATCGTCGAAAGGACGGCTGGTCATCGGCACCGG
GGCCTTGTTGCTGCTCGCTTTCGCGGTGTCGTATGTCGAGCCGGCCTGGTCGAACTGGGCCTACATCGCCGCCACTCTGG
TCAGTCTAATTCCGATCGGCCGGCGTGCGCTCACCGGCGCCTTATCGGGCACGCCATTCAGCATCGAGATGCTGATGTCG
ATCGCCGCAGTCGGCGCCGTCGCTATCGGCGAGGCAGAAGAGGCCGCCGTCGTCGTGTTCCTCTTCGCGGTCGGCGAACT
GCTGGAAGGCGTCGCTGCCGGGCGGGCACGCGCCGGCATCAAAGCGTTGATCGATCTCGTACCGCGAACTGCGCGCCGCC
AGATCGGCTCCAACGTGGAAACGATACCAGTCGAAGATCTGGCCATCGGCGATACCGTGGTTGTCCGGCCGGGCGACCGA
GTACCTTCCGACGGGACCGTGATCGAGGGCGTATCCGAGGTCAACGAGGCGCCGGTGACCGGCGAATCTGTCCCGGTCGG
CAAGGAACCCGGATCGACGGTCTATGCCGGCAGCATCAACGCCAATGGCGAGTTGCGTGTCGAGATCACCCGGACGGCCG
CCGATAACACAATTGCCCGGATCGTCCATATGGTCGAGGAAGCGCAGGGCTCGAAGGCGCCGACGGCTCGTTTCATAGAC
CGCTTCAGTCGCTGGTACACGCCGGCCGCCATGGCCGTGTCGGCGCTCGTCGTCCTCGTTCCGCCGCTGCTGTTCGGCGC
CGACTGGTTCACCTGGATCTATCGTGGGCTGGCGGTGCTGCTGATCGCGTGTCCCTGTGCTCTGGTGATATCCACCCCGG
CTGCGATCGCTTCAGGGTTGGCCAGTGGCGCACGACGCGGTCTCCTCATCAAAGGGGGCGCGGCACTGGAAACGCTCGGC
AAGGTCAAAGCCGTTGCCTTCGACAAGACCGGCACGCTGACCATGGGTCACCCGCAAGTCACCGATGTTGTCGTGGTCGA
AGGCACGGAAGCCGATATCCTGGCGAAGTCCGCTGCCGTCGAACGTGGCTCCAGCCATCCGCTGGGAGCGGCGATTGTCG
CCGAGGCCGAAAGGCGCGGTCTCGATATCCCCAAAGCCTTCGGCGGCGGGATCGCGACGCCCGGCAAAGCAGTAACGGCG
CGACTCAAATCTGGTTTCGTCTCGGTCGGATCGCCACGCCACGCCAGCGAACAAGGCGAGGTGCCCGAGGAAGTCAGGAA
ACAGATCGAGGAGCTCGAAAGCCAAGGCAAGACCGTGGTTGTGGTCAGCGAGGGTAAGCAACTTGTCGGACTGATCGCGC
TGCGTGACGAGCCGCGTCCGGATGCTGCTGACGGCCTTGCGAAGCTCCGCACTCTTGGCATACGCGCCGTCATGCTGACC
GGCGACAATGCCCGCACGGCGACTGCGATCGGCGGCGCACTCGGACTTGATATCAGGGCCGAACTGCTGCCGGACGCCAA
GCTCGACGCGATCTCAGCTTATAAGAGCGAAGGCCCTATCGCCATGGTCGGCGACGGCATCAACGATGCGCCCGCGCTTG
CCGCGTCCTCGGTGGGCATCGCGATGGGAGGCGGCACGGACGTGGCATTGGAGACTGCGGACGCGGCGCTTCTGAAAAAC
CGTGTCACCGGCGTTGCCGAATTGATCGCGCTATCGCGCGCGACGCTCGCCAATATCTGGCAGAACATCACGCTCGCGCT
CAGCCTGAAGGGCATTTTTCTCGTCACCACGCTTTTCGGCGCAACACCGCTCTGGATGGCGATCCTAGCCGACACTGGTG
CGACCGTTTTGGTAACTGCAAACGCCTTACGGCTGCTGCGCTTTGAGTTCAAAGCGTGA

Protein sequence :
MATASPLKLRIEGMDCGACAAKIENAMKRLPGVSDIDVNYSLQSLSLAVDEDRTSRGTIEAKIRALGYAPVDPSEQVMSA
GHRDGDRDTAEGTWWSSSKGRLVIGTGALLLLAFAVSYVEPAWSNWAYIAATLVSLIPIGRRALTGALSGTPFSIEMLMS
IAAVGAVAIGEAEEAAVVVFLFAVGELLEGVAAGRARAGIKALIDLVPRTARRQIGSNVETIPVEDLAIGDTVVVRPGDR
VPSDGTVIEGVSEVNEAPVTGESVPVGKEPGSTVYAGSINANGELRVEITRTAADNTIARIVHMVEEAQGSKAPTARFID
RFSRWYTPAAMAVSALVVLVPPLLFGADWFTWIYRGLAVLLIACPCALVISTPAAIASGLASGARRGLLIKGGAALETLG
KVKAVAFDKTGTLTMGHPQVTDVVVVEGTEADILAKSAAVERGSSHPLGAAIVAEAERRGLDIPKAFGGGIATPGKAVTA
RLKSGFVSVGSPRHASEQGEVPEEVRKQIEELESQGKTVVVVSEGKQLVGLIALRDEPRPDAADGLAKLRTLGIRAVMLT
GDNARTATAIGGALGLDIRAELLPDAKLDAISAYKSEGPIAMVGDGINDAPALAASSVGIAMGGGTDVALETADAALLKN
RVTGVAELIALSRATLANIWQNITLALSLKGIFLVTTLFGATPLWMAILADTGATVLVTANALRLLRFEFKA

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
ORF C97 AAN62190.1 putative metal-transporting P-type ATPase Not tested PAGI-2(C) Protein 2e-101 42
cadA BAC57487.1 Probable cadmium-transporting ATPase (Cadmium efflux ATPase) Not tested Type-IIIinv SCCmec Protein 6e-103 41
unnamed BAB47609.1 cadmium resistance protein B Not tested Type-III SCCmec Protein 6e-103 41
SE0075 NP_763630.1 cadmium resistance protein B Not tested SCCpbp4 Protein 1e-102 41

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
cadA3 YP_002287036.1 cadmium-translocating P-type ATPase BAC0461 Protein 6e-122 49
cadA3 YP_002287036.1 cadmium-translocating P-type ATPase BAC0092 Protein 2e-80 42
cadA3 YP_002287036.1 cadmium-translocating P-type ATPase BAC0298 Protein 7e-95 41
cadA3 YP_002287036.1 cadmium-translocating P-type ATPase BAC0183 Protein 1e-70 41