Gene Information

Name : nrdE.2 (Spy49_0341)
Accession : YP_002285372.1
Strain : Streptococcus pyogenes NZ131
Genome accession: NC_011375
Putative virulence/resistance : Unknown
Product : ribonucleotide-diphosphate reductase subunit alpha
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0209
EC number : 1.17.4.1
Position : 355166 - 357346 bp
Length : 2181 bp
Strand : +
Note : Catalyzes the rate-limiting step in dNTP synthesis

DNA sequence :
ATGTCACAAACCAATGCGTCATACCTCTCATTAAATGCACTGACCCGTTTTAAAAAACCAGACGGCAGCTACCATTTTGA
TAGTGATAAAGAAGCTGTTAGGCGCTACCTGGAAGAACATGTCTCACCCAATCAAATGGCTTTTAACTCACTAGAAGATA
AGCTAGCTTACCTCATCAATGAAGGGTATTATGAGCAGGCCATTTTTGATGCCTATCCTAATGACCTTATCAAGGAGGCC
TTTCATTATGCCTATCAACAAGGCTATCGCTTTTTAAATCTCATGGGCGCTATGAAATTTTACCAGTCCTATGCCTTAAA
AACCTTGGACGGTAAGCAGTATCTAGAAACATTTGAAGACCGTGCTGTGATGAATGCACTCTTTTTAGCTGATGGAGATC
AAACCTTTGTCTTTGACGTGATTGATGCCATCTTGCACCGACGCTTTCAACCAGCTACCCCAACGTTTTTAAATTCCGGA
AAAAAACGCCGTGGCGAATACATTTCGTGCTACCTTCTTCGTGTCGAAGACAATATGGAATCTATCTCTCGCGCCATTAG
CACCAGCTTGCAACTCTCAAAAAGAGGAGGCGGAGTCGCCTTGTGCCTCACCAACCTCAGAGAAATCGGAGCACCGATAA
AAGGGATTGAAAATCAGGCAACAGGCATCGTTCCTGTCATGAAACTACTAGAGGACTCTTTTTCCTATGCCAATCAACTA
GGTCAGCGCCAAGGAGCAGGTGCGGTTTACCTTCATGCCCATCATCCTGAGGTCTTGACCTTTTTAGATACCAAACGTGA
AAATGCCGATGAGAAAATTCGCATTAAGTCCCTAGCATTGGGACTTGTGATCCCAGATATTACCTTCCAGTTAGCCAAAG
AAAACAAAGACATGGCTCTCTTTTCACCCTATGATATCAAGCGTGCCTATGGCAAGGACATGTCAGACATCTCCATCACA
GAGGAATACGATAAACTGCTAGCCAATCCAGCCATCAAAAAGACTTACATCAGTGCTAGAAAGCTCTTTCAGTTAATTGC
AGAGCTACATTTTGAGTCAGGCTACCCTTACCTCTTGTTTGATGACACGGTCAATAAGCGCAACCCTCATGCCAAAAAAG
GCAGAATCGTCATGTCTAACCTGTGTTCTGAAATCGCTCAAGTCAGCACCCCAAGCACTTTCAAAGAAGATTTGAGTTTT
GAAACCATTGGAGAAGATATCTGCTGTAATTTAGGGTCTATCAATATTGCCCAGGCTATGGCAGATGCGCCACACTTTGA
ACAGCTCATCACAACAAGCATCAGAGCACTTGATCGTGTCTCTAGAGTGTCTGACCTGAATTGTGCGCCTTCTGTTGAGA
CAGGCAATGCAGCCAACCATGCAGTAGGATTAGGCGCCATGAACCTACATGGGTTTTTGGCAACCAACCACATCTACTAT
GATACAAAAGAAGCCGTTGACTTTACAGATCTGTTTTTCCATGCCATGGCCTATTATGCTTTTAAAGCCTCTTGCCAATT
AGCCAAAGAAAAAGGCGCTTTTGCAGGATTTTCGTTATCAACCTATGCAGATGGCACTTATTTTGCCAAGTATTTGCAAG
AAGATGCCAAGCCACAAACAGCCAAGGTTGCCACATTGTTGCAAGATTACGGCTTCACATTGCCAACGGTGGCGGATTGG
CAAGCCCTAGTAGCAGATATCAAGCAGTTTGGTCTAGCCAATGCGCACTTGCTAGCGGTTGCTCCGACAGGCTCCATCAG
CTACTTATCATCCTGCACTCCGAGTCTACAACCAGTCGTTGCTCCTGTTGAGGTCCGAAAAGAAGGTAGCCTGGGCAGGA
TTTACGTCCCTGCCTATCAGATTGACCAGGCTAACTATACTTACTATGAACGTGGTGCCTATGAGGTCGGCCCAAAAGCC
ATCATCGACGTTGTAGCTGCTGCCCAAAAACACGTTGACCAAGCCATCTCATTGACCCTGTTTATGACCGATCAAGCGAC
CACACGTGACCTGAACCGCTCCTATATCCAAGCTTTTAAGCAAAACTGTGCATCGATCTATTATGTGCGAGTGAGGCAAG
ACGTCCTAGCAGGCAGCGAACAGTATGACGAGGATAGTCTTGTGACAGCTCCTGGAGCTAGTGATGAAACCACCACAGAA
TGTCAAAGCTGTATGATCTAA

Protein sequence :
MSQTNASYLSLNALTRFKKPDGSYHFDSDKEAVRRYLEEHVSPNQMAFNSLEDKLAYLINEGYYEQAIFDAYPNDLIKEA
FHYAYQQGYRFLNLMGAMKFYQSYALKTLDGKQYLETFEDRAVMNALFLADGDQTFVFDVIDAILHRRFQPATPTFLNSG
KKRRGEYISCYLLRVEDNMESISRAISTSLQLSKRGGGVALCLTNLREIGAPIKGIENQATGIVPVMKLLEDSFSYANQL
GQRQGAGAVYLHAHHPEVLTFLDTKRENADEKIRIKSLALGLVIPDITFQLAKENKDMALFSPYDIKRAYGKDMSDISIT
EEYDKLLANPAIKKTYISARKLFQLIAELHFESGYPYLLFDDTVNKRNPHAKKGRIVMSNLCSEIAQVSTPSTFKEDLSF
ETIGEDICCNLGSINIAQAMADAPHFEQLITTSIRALDRVSRVSDLNCAPSVETGNAANHAVGLGAMNLHGFLATNHIYY
DTKEAVDFTDLFFHAMAYYAFKASCQLAKEKGAFAGFSLSTYADGTYFAKYLQEDAKPQTAKVATLLQDYGFTLPTVADW
QALVADIKQFGLANAHLLAVAPTGSISYLSSCTPSLQPVVAPVEVRKEGSLGRIYVPAYQIDQANYTYYERGAYEVGPKA
IIDVVAAAQKHVDQAISLTLFMTDQATTRDLNRSYIQAFKQNCASIYYVRVRQDVLAGSEQYDEDSLVTAPGASDETTTE
CQSCMI

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
cur_1481 YP_001800875.1 ribonucleotide-diphosphate reductase subunit alpha Not tested Not named Protein 0.0 55