Gene Information

Name : tkt (Spy49_1300c)
Accession : YP_002286277.1
Strain : Streptococcus pyogenes NZ131
Genome accession: NC_011375
Putative virulence/resistance : Unknown
Product : transketolase
Function : -
COG functional category : G : Carbohydrate transport and metabolism
COG ID : COG0021
EC number : 2.2.1.1
Position : 1306904 - 1308889 bp
Length : 1986 bp
Strand : -
Note : catalyzes the formation of ribose 5-phosphate and xylulose 5-phosphate from sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate; can transfer ketol groups between several groups; in Escherichia coli there are two tkt genes, tktA expressed during expo

DNA sequence :
ATGACATTTGATGCAATTGACCAGTTGGCAGTAAATACTGTCCGCACCCTATCAATGGATGCCATTCAAGCGGCAAATTC
TGGACACCCAGGCCTTCCAATGGGTGCTGCACCTATGGCCTACGTTCTTTGGAATCACTTCATGAACATTAATCCAAAAA
CAAGCCGTAATTGGTCAAACAGAGACCGTTTTATCCTATCAGCGGGACACGGAAGTGCTATGCTTTATAGCTTGTTACAC
TTAGCTGGTTATGATTTATCTGTAGAGGATTTGAAAAACTTCCGTCAATGGGGATCTAAAACACCAGGTCACCCAGAAGT
GAGACCACACAGACGGTGTCGAAGCAACCACAGACCTCTTGGTCAAGGGATCGCAAATGCCGTTGGTATGGCCATGGCAG
AAGCTCATCTAGCAGCTAAATTTAACAAACCAGGCTTTGACATCGTTGATCATTACACATTTGCTTTGAATGGTGACGGT
GACCTTATGGAAGGTGTCAGTCAAGAAGCAGCAAGTATGGCAGGACACTTAAAACTTGGCAAATTGGTCTTGCTTTACGA
TTCAAACGATATCTCTCTTGATGGTCCAACCTCAATGTCCTTTACAGAAGATGTTAAAGGACGTTTCGAAGCTTACGGTT
GGCAACATATCCTTGTGAAAGATGGAAATGATTTAGAAGAAATTGCAGCTGCTATTGAAGCAGCTAAAGCTGAAACTGAG
AAACCAACCATCATCGAAGTCAAAACCATTATTGGTTTTGGTGCCGAAAAACAAGGAACTTCAGCTGTTCACGGCGCTCC
TCTTGGAGCAGAAGGCATTGCTTTTGCCAAAAAAGCTTACCAATGGACTCATCAAGATTTTGAAGTGCCTGCTGAAGTAA
CAGAGCGCTTTGCTCAAGGTCTTCAAGCGCGTGGTGAAAAAGCAGAACAAGCCTGGAATGACTTGTTTGCAGCTTATGAA
GCAGAATATCCAGAATTAGCAGCAGAATACCAAAAAGCCTTTACTAACGAAGCTGCTCAAGTAGAACTTGAAGCGCACGA
ACTTGGTAGTTCAATGGCGAGTCGTGTATCCAGTCAACAAGCCATCCAACAAATTTCAGAACAAGTAGCCTCTTTCTGGG
GTGGGTCAGCAGACCTTTCAGCTTCAAACAATACTATGGTTAAGGCTGAAACAGATTTCCAACCAGGTCACTATGAAGGC
CGTAACGTCTGGTTTGGCGTTCGTGAATTTGCCATGGCTGCAGCTATGAATGGTATTGCCCTTCACGGCGGGACACGCGT
TTACGGTGGAACCTTCTTTGTCTTTTCAAACTATCTTCTTCCAGCTGTTCGTATGGCAGCGCTCCAAAACTTGCCAACAG
TTTATGTCATGACACATGATTCTATCGCTGTCGGTGAAGATGGGCCAACGCACGAACCAATTGAACAATTGGCAAGTGTT
CGTTCAATGCCTAACTTGAACGTTATTCGTCCAGCAGACGGTAACGAAACAAATGCTGCTTGGAAACGTGCCATTGCTGA
AACAGATCGCCCAACCATGCTTGTATTGACGCGTCAAAACCTCCCAGTGCTTGAGGGCACAAAAGAATTGGCAGAAGATG
GTCTTAACAAAGGAGCTTACATCTTGTCAGAAGCCAAAGGCGACCTTGAAGGTATCTTGATTGCAACAGGTTCAGAAGTT
AAATTAGCTTTAGATACTCAAGATAAACTTGAGTCAGAAGGCATTCATGTTCGCGTCGTATCTATGCCATCGCAAAATAT
CTTTGACGAACAGTCAGCAGAGTATAAAGAAAGCATCCTACCAGCAGCTGTGACTAAACGTCTCGCTATCGAAGCAGGTT
CAAGCTTTGGCTGGGCAAAATATGTCGGCCTAGCAGGAAAAACATTGACCATTGACACTTGGGGTGCTTCAGCTCCAGGA
AATCGTATCTTCGAAGAATATGGTTTCACTGTGGCAAATGCAACTGAGTTATACAAATCACTCTAG

Protein sequence :
MTFDAIDQLAVNTVRTLSMDAIQAANSGHPGLPMGAAPMAYVLWNHFMNINPKTSRNWSNRDRFILSAGHGSAMLYSLLH
LAGYDLSVEDLKNFRQWGSKTPGHPEVRPHRRCRSNHRPLGQGIANAVGMAMAEAHLAAKFNKPGFDIVDHYTFALNGDG
DLMEGVSQEAASMAGHLKLGKLVLLYDSNDISLDGPTSMSFTEDVKGRFEAYGWQHILVKDGNDLEEIAAAIEAAKAETE
KPTIIEVKTIIGFGAEKQGTSAVHGAPLGAEGIAFAKKAYQWTHQDFEVPAEVTERFAQGLQARGEKAEQAWNDLFAAYE
AEYPELAAEYQKAFTNEAAQVELEAHELGSSMASRVSSQQAIQQISEQVASFWGGSADLSASNNTMVKAETDFQPGHYEG
RNVWFGVREFAMAAAMNGIALHGGTRVYGGTFFVFSNYLLPAVRMAALQNLPTVYVMTHDSIAVGEDGPTHEPIEQLASV
RSMPNLNVIRPADGNETNAAWKRAIAETDRPTMLVLTRQNLPVLEGTKELAEDGLNKGAYILSEAKGDLEGILIATGSEV
KLALDTQDKLESEGIHVRVVSMPSQNIFDEQSAEYKESILPAAVTKRLAIEAGSSFGWAKYVGLAGKTLTIDTWGASAPG
NRIFEEYGFTVANATELYKSL

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
tktA AAO17218.1 TktA Not tested tcd island Protein 1e-122 50
APECO1_2641 YP_859417.1 transketolase Not tested Not named Protein 8e-120 48