Gene Information

Name : cagA (HPG27_507)
Accession : YP_002266135.1
Strain : Helicobacter pylori G27
Genome accession: NC_011333
Putative virulence/resistance : Virulence
Product : cytotoxin-associated protein A
Function : -
COG functional category : -
COG ID : -
EC number : -
Position : 548263 - 551955 bp
Length : 3693 bp
Strand : +
Note : -

DNA sequence :
ATGACTAACGAAACCATTAACCAACAACCACAAACTGAAGCGGCTTTTAACCCGCAGCAATTTATCAATAATCTTCAAGT
GGCTTTTCTTAAAGTTGATAACGCTGTCGCTTCATACGATCCTGATCAAAAACCAATCGTTGATAAGAACGATAGGGATA
ACAGGCAAGCTTTTAATGGAATCTCGCAATTAAGGGAAGAATACTCCAATAAAGCGATCAAAAATCCTGCCAAAAAGAAT
CAGTATTTTTCAGACTTTATCGATAAGAGCAATAATTTAATCAACAAAGACGCTCTCATTGATGTAGAATCTTCCACAAA
GAGCTTTCAGAAATTTGGGGATCAGCGTTACCAAATTTTCACAAGTTGGGTGTCCCATCAAAACGATCCGTCTAAAATCA
ACACCCGATCGATCCGAAATTTTATGGAAAATATCATACAACCCCCTATCCCTGATGATAAAGAAAAAGCAGAGTTTTTG
AAATCTGCCAAACAATCTTTTGCAGGAATTATCATAGGGAATCAAATCCGAACGGATCAAAAGTTCATGGGCGTGTTTGA
TGAATCCTTGAAAGAAAGGCAAGAAGCAGAAAAAAATGGAGGGCCTACTGGTGGGGATTGGTTGGATATTTTTCTCTCAT
TTATATTTGACAAAAAACAATCTTCTGATGTCAAAGAAGCAATCAATCAAGAACCAGTTCCCCATGTCCAACCAGATATA
GCCACTACCACCACCGACATACAAGGCTTACCGCCTGAAGCTAGAGATTTACTTGATGAAAGGGGTAATTTTTCTAAATT
CACTCTTGGCGATATGGAAATGTTAGATGTTGAGGGAGTCGCTGACATTGATCCTAATTACAAGTTCAACCAATTATTGA
TTCACAATAACGCTCTGTCTTCTGTGTTAATGGGGAGTCATAATGGCATAGAACCTGAAAAAGTTTCATTGTTGTATGGG
GGCAATGGTGGTCCTAAAGCTAAGCATGATTGGAACGCCACCGTTGGTTATAAAGACCAACAAGGTAACAATGTGGCTAC
AATAATTAATGTGCATATGAAAAACGGCAGTGGCTTAGTCATAGCAGGTGGTGAGAAAGGGATTAATAATCCTAGTTTTT
ATCTCTACAAAGAAGACCAACTCACAGGCTCACAACGAGCATTGAGTCAAGAAGAGATCCGAAACAAAGTAGATTTCATG
GAATTTCTTGCACAAAATAATGCTAAATTAGACAACTTGAGCGAGAAAGAGGAAGAAAAATTCCGAAATGAGATTAAGGA
TTTCCAAAAAGACTCTAAGGCTTATTTAGACGCCCTAGGGAATGATCGTATTGCTTTTGTTTCTAAAAAAGACACAAAAC
ATTCAGCTTTAATTACTGAGTTTGGTAATGGGGATTTGAGCTACACTCTCAAAGATTATGGGAAAAAAGCAGATAAAGCT
TTAGATAGGGAGAAAAATGTCACTCTTCAAGGTAACCTAAAACATGATGGCGTGATGTTTGTTGATTATTCTAATTTCAA
ATACACCAACGCCTCCAAGAATCCCAATAAGGGTGTAGGCGTTACGAATGGCGTTTCCCATTTAGAAGCAGGCTTTAGCA
AGGTAGCTGTCTTTAATTTGCCTGATTTAAATAATCTCGCTATCACTAGTTTAGTAAGGCGGGATTTAGAGGATAAACTA
ATCGCTAAAGGATTGTCCCCACAAGAAACTAATAAGCTTGTCAAAGATTTTTTGAGCAGCAACAAAGAATTGGTTGGAAA
AGCTTTAAACTTCAATAAAGCTGTAGCTGAAGCTAAAAACACAGGCAACTATGATGAAGTGAAACAAGCTCAGAAAGATC
TTGAAAAATCTCTAAAGAAACGAGAGCGTTTGGAGAAAGAAGTAGCGAAAAAATTGGAGAGCAAAAGCGGCAACAAAAAC
AAAATGGAAGCAAAATCTCAAGCTAACAGCCAAAAAGATGAGATTTTTGCGTTGATCAATAAAGAGGCTAATAGGGAGGC
AAGAGCAATCACTTACGCTCAAAATCTTAAAGGCATCAAAAGGGAATTGTCTGATAAACTTGAGAATGTCAACAAAAATT
TGAAAGACTTTAGTAAATCTTTTGATGAATTCAAAAATGGCAAAAATAAGGATTTCAGCAAGTCAGAAGAAACACTAAAA
GCCCTTAAAGGCTCGGTGAAAGATTTAGGTATCAATCCAGAATGGATTTCAAAAGTTGAAAACCTTAATGCAGCTTTGAA
TGAATTCAAAAATGGCAAAAATAAGGATTTCAGCAAGGTAACGCAAGCAAAAAGCGACCTTGAAAATTCCGTTAAAGATG
TGATCATCAATCAAAAGGTAACGGATAAAGTTGACAATCTCAATCAAGCGGTATCAGTGGCTAAAGCAACGGGTGATTTC
AGTAGGGTAGAGCAAGCGTTAGCCGATCTCAAAAACTTCTCAAAGGAGCAATTGGCTCAACAAGCTCAAAAAAATGAAGA
TTTCAATACTGGAAAAAATTCTGCACTATACCAATCCGTTAAGAATGGTGTGAATGGAACCCTAGTCGGTAATGGGTTAT
CTAAAGCAGAAGCCACAACTCTTTCTAAAAACTTTTCGGACATCAAGAAAGAGTTGAATGCAAAACTTGGAAATTTCAAT
AACAATAACAATAATGGACTCAAAAACAGCACAGAACCCATTTATGCTAAAGTTAATAAAAAGAAAGCAGGGCAAGCAGC
TAGCCCTGAAGAACCCATTTACGCTCAAGTTGCTAAAAAGGTAAATGCAAAAATTGACCGACTCAATCAAATAGCAAGTG
GTTTGGGTGTTGTAGGGCAAGCAGTGGGCTTCCCTTTGAAAAGGCATGATAAAGTTGGTGATCTCAGTAAGGTAGGGCAA
TCAGTTAGCCCTGAACCCATTTATGCTACGATTGATGATCTCGGCGGACCTTTCCCTTTGAAAAGGCATGATAAAGTTGG
TGATCTCAGTAAGGTAGGGCTTTCAGTTAGCCCTGAACCCATTTATGCTACGATTGATGATCTCGGCGGACCTTTCCCTT
TGAAAAGGCATGATAAAGTTGGTGATCTCAGTAAGGTAGGGCTTTCAAGGGAGCAACAATTGAAACAGAAGATTGACAAT
CTCAGTCAAGCGGTATCAGAAGCTAAAGCAGGTTTTTTTGGCAATCTAGAACAAACGATAGACAATCTCAAAGATTCTGC
AAAAAACAATCCTGTGAGTCTATGGGCTGAAGGTGCAAAAAAAGTGCCTGCTAGTTTGTCAGCGAAACTAGACAATTACG
CTACTAACAGCCACACACGCATTAATAGCAATATCCAAAGTGGAGCAATCAATGAAAAAGCGACCGGTATGCTAACGCAA
AAAAACCCTGAGTGGCTCAAGCTCGTGAATGATAAGATCGTTGCGCATAATGTAGGAAGCGTTCCTTTGTTAGAGTATGA
TAAAATTGGCTTCAACCAGAAGAGTATGAAAGATTATTCTGATTCGTTCAAGTTTTCCACCGAGTTGAACAATGCTGTAA
AAGATGTTAAGTCTGGCTTTACGCAATTTTTAGCCAATGCATTTTCTACAGGATATTACCGCTTGGCGGGAGAAAATGCA
GAGCATGGAATCAAAAATGTTAATACAAAAGGTGGTTCCAAAAATCTTAAAGGATTAAGGAATACCAAAAACGCAAAAAC
CACCCCTTGCTAA

Protein sequence :
MTNETINQQPQTEAAFNPQQFINNLQVAFLKVDNAVASYDPDQKPIVDKNDRDNRQAFNGISQLREEYSNKAIKNPAKKN
QYFSDFIDKSNNLINKDALIDVESSTKSFQKFGDQRYQIFTSWVSHQNDPSKINTRSIRNFMENIIQPPIPDDKEKAEFL
KSAKQSFAGIIIGNQIRTDQKFMGVFDESLKERQEAEKNGGPTGGDWLDIFLSFIFDKKQSSDVKEAINQEPVPHVQPDI
ATTTTDIQGLPPEARDLLDERGNFSKFTLGDMEMLDVEGVADIDPNYKFNQLLIHNNALSSVLMGSHNGIEPEKVSLLYG
GNGGPKAKHDWNATVGYKDQQGNNVATIINVHMKNGSGLVIAGGEKGINNPSFYLYKEDQLTGSQRALSQEEIRNKVDFM
EFLAQNNAKLDNLSEKEEEKFRNEIKDFQKDSKAYLDALGNDRIAFVSKKDTKHSALITEFGNGDLSYTLKDYGKKADKA
LDREKNVTLQGNLKHDGVMFVDYSNFKYTNASKNPNKGVGVTNGVSHLEAGFSKVAVFNLPDLNNLAITSLVRRDLEDKL
IAKGLSPQETNKLVKDFLSSNKELVGKALNFNKAVAEAKNTGNYDEVKQAQKDLEKSLKKRERLEKEVAKKLESKSGNKN
KMEAKSQANSQKDEIFALINKEANREARAITYAQNLKGIKRELSDKLENVNKNLKDFSKSFDEFKNGKNKDFSKSEETLK
ALKGSVKDLGINPEWISKVENLNAALNEFKNGKNKDFSKVTQAKSDLENSVKDVIINQKVTDKVDNLNQAVSVAKATGDF
SRVEQALADLKNFSKEQLAQQAQKNEDFNTGKNSALYQSVKNGVNGTLVGNGLSKAEATTLSKNFSDIKKELNAKLGNFN
NNNNNGLKNSTEPIYAKVNKKKAGQAASPEEPIYAQVAKKVNAKIDRLNQIASGLGVVGQAVGFPLKRHDKVGDLSKVGQ
SVSPEPIYATIDDLGGPFPLKRHDKVGDLSKVGLSVSPEPIYATIDDLGGPFPLKRHDKVGDLSKVGLSREQQLKQKIDN
LSQAVSEAKAGFFGNLEQTIDNLKDSAKNNPVSLWAEGAKKVPASLSAKLDNYATNSHTRINSNIQSGAINEKATGMLTQ
KNPEWLKLVNDKIVAHNVGSVPLLEYDKIGFNQKSMKDYSDSFKFSTELNNAVKDVKSGFTQFLANAFSTGYYRLAGENA
EHGIKNVNTKGGSKNLKGLRNTKNAKTTPC

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
cagA AAC44706.1 CagA Virulence cag PAI Protein 0.0 94
cagA BAD51747.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 93
cagA BAC10428.1 CagA Virulence cag PAI Protein 0.0 92
HP0547 BAD13908.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 92
cagA AAR03970.1 CagA Virulence cag PAI Protein 0.0 91
HP0547 BAD14045.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 90
cagA AAR03881.1 CagA Virulence cag PAI Protein 0.0 90
HP0547 NP_207343.1 cag pathogenicity island protein (cag26) Virulence cag PAI Protein 0.0 89
cagA AAF17598.1 CagA Virulence cag PAI Protein 0.0 89
cagA AAR03909.1 CagA Virulence cag PAI Protein 0.0 88
cagA BAC10429.1 CagA Virulence cag PAI Protein 0.0 86
HP0547 BAD13935.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 86
cagA AAR03939.1 CagA Virulence cag PAI Protein 0.0 86
cagA NP_223213.1 cag island protein, cytotoxicity associated immunodominant antigen Virulence cag PAI Protein 0.0 85
cagA BAD51759.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 85
cagA BAD51750.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 83
cagA BAD51756.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 83
cagA BAD51758.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 82
cagA BAD51751.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 82
cagA BAD51760.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 82
cagA YP_003728762.1 cytotoxin-associated protein A Virulence cag PAI Protein 0.0 82
cagA BAD51753.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 82
cagA AGC69806.1 cag pathogenicity island protein A Virulence cag PAI Protein 0.0 82
cagA BAC10432.1 CagA Virulence cag PAI Protein 0.0 82
HP0547 BAD13990.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 82
cagA BAD51752.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 81
cagA BAD51761.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 81
cagA BAD51766.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 81
cagA BAD51764.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 80
HP0547 BAD13963.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 77
cagA BAC10435.1 CagA Virulence cag PAI Protein 0.0 77
cagA BAC10426.1 CagA Virulence cag PAI Protein 0.0 77
HP0547 BAD14072.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 77
cagA BAD51755.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 77
cagA BAC10431.1 CagA Virulence cag PAI Protein 0.0 77
cagA BAD51754.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 77
HP0547 BAD13799.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 76
cagA BAD51744.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 76
cagA BAC10419.1 CagA Virulence cag PAI Protein 0.0 76
cagA BAC10420.1 CagA Virulence cag PAI Protein 0.0 76
cagA YP_005777288.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 76
cagA BAC10421.1 CagA Virulence cag PAI Protein 0.0 76
cagA YP_005775747.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 76
cagA BAD51762.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 76
HP0547 BAD13880.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 76
cagA BAD51749.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 76
cagA AAF17597.1 CagA Virulence cag PAI Protein 0.0 76
cagA YP_005779046.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 76
cagA BAC10433.1 CagA Virulence cag PAI Protein 0.0 76
HP0547 BAD14018.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 76
cagA YP_005774524.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 75
cagA BAC10430.1 CagA Virulence cag PAI Protein 0.0 75
cagA BAC10423.1 CagA Virulence cag PAI Protein 0.0 75
cagA BAC10427.1 CagA Virulence cag PAI Protein 0.0 75
HP0547 BAD13853.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 75
cagA BAC10424.1 CagA Virulence cag PAI Protein 0.0 74
cagA BAC10422.1 CagA Virulence cag PAI Protein 0.0 67
HP0547 BAD13826.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 67

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
cagA YP_002266135.1 cytotoxin-associated protein A VFG0306 Protein 0.0 89