Gene Information

Name : HPG27_98 (HPG27_98)
Accession : YP_002265733.1
Strain : Helicobacter pylori G27
Genome accession: NC_011333
Putative virulence/resistance : Resistance
Product : cystathionine gamma-synthase/cystathionine beta-lyase
Function : -
COG functional category : E : Amino acid transport and metabolism
COG ID : COG0626
EC number : -
Position : 112740 - 113882 bp
Length : 1143 bp
Strand : -
Note : catalyzes the formation of L-cystathionine from O-succinyl-L-homoserine and L-cysteine; or Cystathionine beta-lyase (CBL) can convert cystathionine to homocysteine

DNA sequence :
ATGCGCATGCAAACAAAACTAATCCATGGGGGCATTAGTGAGGATACGACAACGGGGGCGGTGAGCGTGCCTATTTATCA
AACTTCCACCTACCGCCAAGACGCCATAGGCCGCCATAAGGGTTATGAATACTCTCGCTCAGGCAACCCCACGCGCTTTG
CTTTAGAAGAACTCATCGCCGATTTAGAGGGGGGGGTTAAGGGGTTTGCTTTTGCTTCTGGACTAGCTGGAATCCACGCC
GTTTTTTCCCTCTTGCAATCAGGCGATCATGTGTTGTTAGGCGATGATGTTTATGGGGGGACTTTCCGCTTGTTCAACAA
AGTGCTTGTCAAAAACGGGCTTTCTTGCACCATTATAGACACTAGCGATCTATCCCAAATCAAAAAGGCTATCAAGCAAA
ACACCAAAGCCCTTTATTTAGAAACCCCTAGTAACCCCTTGCTTAAAATCACGGATTTAGCGCAATGCGCTAGTGTCGCT
AAAGATCATGGTTTGCTCACTATCGTGGATAACACCTTTGCCACCCCCTATTATCAAAACCCGCTTCTTTTGGGGGCGGA
CATTGTAGCACATAGCGGCACAAAATACTTAGGCGGGCATAGCGATGTGGTCGCTGGGCTTGTAACCACTAATAATGAAG
CGCTAGCCCAAGAGATCGCTTTTTTCCAAAACGCTATCGGTGGGGTTTTAGGCCCTCAAGATAGCTGGCTGTTGCAAAGA
GGGATTAAAACGCTGGGATTACGCATGGAGGCCCATCAAAAAAACGCTTTTTGCGTGGCTGAATTTTTAGAAAAACACCC
TAAAGTGGAAAGGGTTTATTACCCGGGCCTTCCCACTCACCCTAATTACGAACTAGCTAAAAAACAGATGCGTGGCTTTA
GCGGGATGCTCTCTTTCACTCTCAAAAATGACAGCGAGGCGGCTCTTTTTGTAGAAAGCCTTAAACTATTCATTTTAGGC
GAGAGCTTGGGCGGGGTGGAAAGTTTGGTGGGGATTCCAGCGTTTATGACCCATGCGTGTATCCCTAAAATGCAACGAGA
AGCTGCCGGGATTAGAGATGGCCTGGTGCGCTTGTCTGTAGGGATTGAGCATGAACAGGATTTGTTAGAAGATTTAGAGC
AAGCGTTCGCTAAAATAGGCTAA

Protein sequence :
MRMQTKLIHGGISEDTTTGAVSVPIYQTSTYRQDAIGRHKGYEYSRSGNPTRFALEELIADLEGGVKGFAFASGLAGIHA
VFSLLQSGDHVLLGDDVYGGTFRLFNKVLVKNGLSCTIIDTSDLSQIKKAIKQNTKALYLETPSNPLLKITDLAQCASVA
KDHGLLTIVDNTFATPYYQNPLLLGADIVAHSGTKYLGGHSDVVAGLVTTNNEALAQEIAFFQNAIGGVLGPQDSWLLQR
GIKTLGLRMEAHQKNAFCVAEFLEKHPKVERVYYPGLPTHPNYELAKKQMRGFSGMLSFTLKNDSEAALFVESLKLFILG
ESLGGVESLVGIPAFMTHACIPKMQREAAGIRDGLVRLSVGIEHEQDLLEDLEQAFAKIG

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
SAS0418 YP_042545.1 Cys/Met metabolism PLP-dependent enzyme Not tested vSa¥á Protein 2e-96 54
SAR0460 YP_039909.1 Cys/Met metabolism PLP-dependent enzyme Not tested vSa¥á Protein 2e-95 54
metB YP_281510.1 cystathionine beta-lyase Not tested Not named Protein 2e-71 47

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
HPG27_98 YP_002265733.1 cystathionine gamma-synthase/cystathionine beta-lyase BAC0207 Protein 5e-62 44