Gene Information

Name : guaA (THEYE_A0205)
Accession : YP_002248055.1
Strain : Thermodesulfovibrio yellowstonii DSM 11347
Genome accession: NC_011296
Putative virulence/resistance : Unknown
Product : GMP synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0519
EC number : 6.3.5.2
Position : 209016 - 210548 bp
Length : 1533 bp
Strand : -
Note : contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway

DNA sequence :
ATGCAGGAAATACTTGTAATAGATTTTGGTTCACAGTACACGCAGCTTATTGCGAGAAGAGTAAGAGAATTAAAGGTTTA
CTCTGAAATAATTCCATGTAATGCACCTTTTTCTGAAATAGAAAAGAGAAATCCTTCAGGAATAATACTTTCAGGTGGTC
CTGCCAGTGTATTTGAAAAAGATTCACCAAGCATTGATAGGAAGATTTTCAATTTAGAGATTCCTATTCTTGGAATATGT
TATGGTATGCAGCTTATTACTCATTTACTTGGAGGCAAAGTCTCCCGAGCTGAAAAAAGAGAGTATGGCAAAGCCATTCT
TAAAATAGATGATTTTTCAGACCTCTTTGCAGAAATCAAAAATGAAACTGTTGTGTGGATGAGCCATGCGGATAAAATCA
ATGAGATGCCTGAAGGTTTTATACGACTTGCTCATACAGAGAATTCTCCCTATGCTGCGATGGCAGACAAAGTGAGAAAA
ATATATGCTTTACAGTTTCATCCTGAGGTTGTACACACTGAGGAAGGGAAAAAGATACTTAAAAATTTTGTGTTCAAGAT
ATGTGGTTGCAAACCAACATGGAATATGCATTCCTTTGTAGAAAGAGAAACAGAAGAAATAAGAAAAAAAGTGGGTAAAT
ATAAAGTTGTATGTGCTTTAAGTGGTGGAGTTGACTCAACTGTTACAGCAGTTTTGGTTCATAAAGCAATAGGAGATGCC
CTTACATGTATATTCGTGGATAATGGACTTTTAAGAGCAGGAGAGCGGGAAAAAGTAGAAGAGATGTTAAGAAATAATTT
TCATATAAATCTTAAAGTAGTGGATGCCTCAGAGAGATTTTTAAAAAGGCTCAAAGGAGTTCATGACCCTGAAAGAAAAA
GAAAAATTATAGGTGGAGAATTTATAAAAATTTTTGAAGAAGAAGCAAAAAAGATTGAAGGAGTAAAATTTCTTGCACAG
GGAACTCTTTATCCTGATGTAATTGAAAGTATTTCTTTTAAAGGACCTTCTGCAACAATAAAGAGTCATCACAATGTTGG
CGGACTTCTTAAAAGAATGAAGTTAAAACTCATTGAGCCTTTGCGTGAGCTTTTTAAAGACGAAGTAAGAGAGCTCGGTA
AAGAACTTGGAATTCCTGAAGAGATTCTTTATCGTCATCCGTTTCCTGGACCTGGGCTTGCCATAAGATGTGTTGGCGAA
GTTACCCGTGAAAGGCTTGAAATTCTAAGACAGGCTGACAAAATAGTGCTTGAAGAGATTAAAAAATCTGGATGGTATAA
AAAAGTATGGCAGTCCTTTGCTGTTTTACTTCCCATAAGAACAGTTGGGGTAATGGGAGATGAGAGAACTTATGAACATG
TTATAGCTATCAGAGCAGTTCACAGCGTAGACGGAATGACAGCAGACTGGGTAAAACTTCCACATGAATTGCTTGAAAGA
CTATCAAATCGGATAATCAATGAAGTAAAGGGTGTAAACAGGGTTGTATATGACATAACATCAAAGCCTCCAGGAACAAT
TGAATGGGAATGA

Protein sequence :
MQEILVIDFGSQYTQLIARRVRELKVYSEIIPCNAPFSEIEKRNPSGIILSGGPASVFEKDSPSIDRKIFNLEIPILGIC
YGMQLITHLLGGKVSRAEKREYGKAILKIDDFSDLFAEIKNETVVWMSHADKINEMPEGFIRLAHTENSPYAAMADKVRK
IYALQFHPEVVHTEEGKKILKNFVFKICGCKPTWNMHSFVERETEEIRKKVGKYKVVCALSGGVDSTVTAVLVHKAIGDA
LTCIFVDNGLLRAGEREKVEEMLRNNFHINLKVVDASERFLKRLKGVHDPERKRKIIGGEFIKIFEEEAKKIEGVKFLAQ
GTLYPDVIESISFKGPSATIKSHHNVGGLLKRMKLKLIEPLRELFKDEVRELGKELGIPEEILYRHPFPGPGLAIRCVGE
VTRERLEILRQADKIVLEEIKKSGWYKKVWQSFAVLLPIRTVGVMGDERTYEHVIAIRAVHSVDGMTADWVKLPHELLER
LSNRIINEVKGVNRVVYDITSKPPGTIEWE

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
guaA YP_001331415.1 GMP synthase Not tested vSa¥á Protein 2e-139 59
SAPIG0468 YP_005733278.1 GMP synthase [glutamine-hydrolyzing] (Glutamineamidotransferase) (GMP synthetase) Not tested SAPI-S0385 Protein 1e-139 59
SAMSHR1132_03620 YP_005324884.1 GMP synthase Not tested vSa¥á Protein 9e-140 59
guaA NP_938969.1 GMP synthase Not tested Not named Protein 7e-121 51