Gene Information

Name : COPRO5265_0867 (COPRO5265_0867)
Accession : YP_002247205.1
Strain : Coprothermobacter proteolyticus DSM 5265
Genome accession: NC_011295
Putative virulence/resistance : Virulence
Product : negative regulator of genetic competence ClpC/mecB
Function : -
COG functional category : O : Posttranslational modification, protein turnover, chaperones
COG ID : COG0542
EC number : -
Position : 788282 - 790699 bp
Length : 2418 bp
Strand : -
Note : identified by match to protein family HMM PF00004; match to protein family HMM PF02151; match to protein family HMM PF02861; match to protein family HMM PF07724; match to protein family HMM PF07728

DNA sequence :
TTGTTTATCAGATTTTCTGAAGAAGCAAGAAAAGCACTTAAGGATGCCCAGGAAGAAGCGCGGCGCCTTAACAGTAGTTT
TGTTGGCAGAGAGCACCTAGTCCTAGCTATGCTCAATGAAGATACGAGGGCATATTCAATAATCGATTCTTTAGGTGCGG
ATGCCGATAATATAAGGAGTTCTATTGAAGATATTCCAATGCCCATGGCTTCAAGTTTGCAGTATCCCGAACTATCTAGT
GAAGCTAGAAGACTTTTGGATATTGCCAGTGAAGAAGCACGCAAGCTTGCTCACTCCTATGTAGGCACAGAACATTTGTT
ACTGGCAATACTCAAGGAACCATCCAGAGTTAGCTCCATACTTAATGAGAACGGTGTTTTTTATGACGACGTAAGAAAAA
AGGTCATAGAAATGGGCGAGCAAGAACCAGAGGAAAAGGGAAAAACAAAAACCCCTGTTCTGGACAAGTTCTCCAAGGAC
CTTGTTTCTTTGGCTGAAAAAGGAAAGTTGGATCCTGTCATAGGTCGTGAAACCGAACTCAACAGGATCATTGAGATATT
GAGCCGCAGAATTAAGAACAATCCCATATTGCTTGGAGAACCTGGCGTGGGTAAGACGGCCATAGTTGAAGGGTTAGCCG
AAAGAATTGCCTCTGGTAAGGTGCCTTATTCGCTAAAGAAGAAGCGTGTTGTACAGCTTGACATTTCTTCCATAGTTGCT
GGAACTAAGTACAGAGGCGAATTTGAAGAACGCATGAAGAAGATCCTTGATGAAGTGAAGCGCACCAATGGTCAAGTGAT
TTTGTTTATTGACGAAATCCATACCGTCATTGGTGCTGGAGCTGCTGAAGGTGCCATCGATGCTGCATCCATATTGAAAC
CATCTTTGGCTCGTGGTGAGATAAAGGTTATTGGTGCAACAACCTATGATGACTACAGAAAGTACATTGAAAGGGACCCC
GCTTTTGAACGTAGATTCCAGCCAGTTCAAGTAGAAGAACCTTCCCTGGAAGAAACTAAGCAAATTCTTATTGGGTTACG
TCCCATTTACGAAAAATTCCACAACGTAAAGATAGCAGATGACGCCATAGAAGCAGCTGCCATATTGACGAAAAAATATG
TGAAGCAAAGATTCCTGCCTGATAAAGCCATAGATGCGTTGGACGAAACATGTGCCAAAGTAAGGCTTGCAAACGAGGTC
TTGCCTAGCAATCTCAGGGCGTTGCTTGACGAAATTGAAAATGTTAGATTGCAGAAACAGTTGGCTATTGACTCTCAACA
GTTTGAAGAAGCGGCTGCATTGCGAGATAAGGAAAAAGCTCTCAAAGAAGAGTACTCAAGGATGGAAGAGATTTGGCTCT
ATGAACGTAGCATGGATGAGAATCAGCCCACGGTGTCTTTCGATGACGTTGCGTACACCATATCTTCTTGGACTGGCATA
CCTGTGGCAAAACTGCGCTTGGATGATAAGAAGAAACTATTAGAGATCGAAGATTATCTGCACCGCAGAATTGTTGGACA
GAACGAAGCGGTTACTGCTGTAGCTAAAGCTATTAGAAGAAGCAGAACGGGCTTGCAAGATGATCGAAGACCCATCGGTG
TCTTCCTTTTCCTTGGCCCCACAGGAGTAGGAAAGACAGAACTTGCGCGTGCTTTAGCCGAGTTCATGTTTGGTGAAGAA
GAGGCCCTGATACGCATTGACATGTCAGAGTACATGGAAAAGTTCAATGTGAGCCGTTTGGTCGGCGCTCCTCCAGGATA
TGTGGGATACGAAGAAGGAGGACAGCTTACTGAAGCGGTTAGAAGGAAACCGCACAGTATTGTGCTTCTAGATGAGATTG
AGAAAGCACATCCAGATGTCTTCGATATATTGCTTCAAATATTCGAAGATGGCCGGCTAACCGATGGTCAAGGTCGTGTA
GTAGATTTTAGGAACACGATCATAATAATGACCTCGAACCTGGGTAGCAGAGATATAAGCGCAGGTACAACCATAGGATT
CTTAAAAGATCAAGTCAAATTTGAAAACATGGAAAACCTTGTCATGGATGCCGTGAAGAAGTTTTTTAAGCCCGAGTTCT
TAAACAGGATCGATGAAATAGTAGTATTCCATCACTTAACAAACGACGATCTAAGACAAATCGTGGGTATCATGATGGAC
GAACTAAACAAACAGCTTCGTTCTCAAAACCTTACGGTTAAAATCTCTGACAGAATGTTAGATCAAATAATCACAGAAGG
ATATGAACCAAGGTTCGGTGCTAGACCATTGAGAAGAGCTATTCAGAGGCTTGTAAAAGATCCTTTGGCCGAGTACATGC
TCAAACACGAAAACATCAGTGGAACATTGTTTATGGATTTCGTAGATGGCGAAATTACAATCAACAAGGTACCAGACGAG
GAAGTTAGTAGAGTTTGA

Protein sequence :
MFIRFSEEARKALKDAQEEARRLNSSFVGREHLVLAMLNEDTRAYSIIDSLGADADNIRSSIEDIPMPMASSLQYPELSS
EARRLLDIASEEARKLAHSYVGTEHLLLAILKEPSRVSSILNENGVFYDDVRKKVIEMGEQEPEEKGKTKTPVLDKFSKD
LVSLAEKGKLDPVIGRETELNRIIEILSRRIKNNPILLGEPGVGKTAIVEGLAERIASGKVPYSLKKKRVVQLDISSIVA
GTKYRGEFEERMKKILDEVKRTNGQVILFIDEIHTVIGAGAAEGAIDAASILKPSLARGEIKVIGATTYDDYRKYIERDP
AFERRFQPVQVEEPSLEETKQILIGLRPIYEKFHNVKIADDAIEAAAILTKKYVKQRFLPDKAIDALDETCAKVRLANEV
LPSNLRALLDEIENVRLQKQLAIDSQQFEEAAALRDKEKALKEEYSRMEEIWLYERSMDENQPTVSFDDVAYTISSWTGI
PVAKLRLDDKKKLLEIEDYLHRRIVGQNEAVTAVAKAIRRSRTGLQDDRRPIGVFLFLGPTGVGKTELARALAEFMFGEE
EALIRIDMSEYMEKFNVSRLVGAPPGYVGYEEGGQLTEAVRRKPHSIVLLDEIEKAHPDVFDILLQIFEDGRLTDGQGRV
VDFRNTIIIMTSNLGSRDISAGTTIGFLKDQVKFENMENLVMDAVKKFFKPEFLNRIDEIVVFHHLTNDDLRQIVGIMMD
ELNKQLRSQNLTVKISDRMLDQIITEGYEPRFGARPLRRAIQRLVKDPLAEYMLKHENISGTLFMDFVDGEITINKVPDE
EVSRV

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
clpC YP_005163377.1 ATP-dependent Clp protease ATP-binding subunit Not tested Not named Protein 5e-178 49

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
COPRO5265_0867 YP_002247205.1 negative regulator of genetic competence ClpC/mecB VFG0079 Protein 0.0 52
COPRO5265_0867 YP_002247205.1 negative regulator of genetic competence ClpC/mecB VFG0080 Protein 9e-139 50