Gene Information

Name : COPRO5265_0843 (COPRO5265_0843)
Accession : YP_002247181.1
Strain : Coprothermobacter proteolyticus DSM 5265
Genome accession: NC_011295
Putative virulence/resistance : Virulence
Product : negative regulator of genetic competence ClpC/mecB
Function : -
COG functional category : O : Posttranslational modification, protein turnover, chaperones
COG ID : COG0542
EC number : -
Position : 762533 - 765013 bp
Length : 2481 bp
Strand : +
Note : identified by match to protein family HMM PF00004; match to protein family HMM PF02151; match to protein family HMM PF02861; match to protein family HMM PF07724; match to protein family HMM PF07728

DNA sequence :
ATGTTTGATGATATATTCCAACAGTTTTTCGGAAACGAGTTTTCAGATTTGTTTCCAGAGTTTTTTGAAAGGAGAAAAAG
AGATATAACAGATTATCTATCATCTTCTTCTTTGTCCATCTTGCAGAATGCAGCAAACCTAGCAGGGGCTGCTGGTTATG
ATGAACTTACGCCTGAGCATTTGGCCTATGCTTTACTCCAATACGAGCCTTTGGCAAATGTACTTGTGGAACACGGCGTT
AATGTCGAAAAGATAAAAGAAGAGCTAGAAGAAAGCCTAACCCCAAAGGGTGAGGCAGTTAGCGAGGTAACAGTTTCGCC
GCAGCTTAAGTCGGTCCTAGAAAGAGCAGCAGATATGGCACGAAACACATTCCGTGGTGAGGCTACTCCGGAACAGCTCT
TGTTTGCCATTCTAGAAGATGGAGGATATGCCGCAAGCATCTTAGAAAGAAACAACCTGAAGCTGAACAATTTAATGGAT
ATTATCGAGGAGGAAAGTCGCACACGTCCTTCTGCAGGTGCTTCACCTTACCAAAGAGGAACACAGACAGCGACCACGGA
ACTAGAAAAGTTCGGAAGAGATCTTACAGAGCTAGCTAGACAAGGGAAACTAGATCCTATAGTAGGTCGAGACTCCGAAA
TACAAAGGGTTCTGGAAATTCTTTCCCGTCGTACTAAGAATAATCCCATTCTAATAGGTGATGCTGGTGTTGGTAAAACG
GCCATTGTAGAAGGCATTGCCCAGAGAATTGCCTCTGGGGATGTACCTGATGCTTTAAAAGGTAAAAGAGTAATCCAATT
GGATATCGGTTCTCTGGTGGCTGGTACTAAGTACCGTGGCGAATTCGAGGAAAGAATGCAGAAAATACTTGATGAGGTAA
TCAAGCAAAAGGACAAAATCATACTGTTCATAGATGAAATTCACACCATAATTGGCGCTGGCGGTGCAGAAGGCGCAGTA
GATGCGTCGAATATGCTAAAACCTGCTTTGGCTCGCGGCGACCTACATGTCATAGGTGCAACAACCATAGATGAATATAG
AAAGTACATTGAAAAGGACCCAGCTTTTGAAAGACGTTTCCAACCCGTGTATGTACCAGAGCCATCGTTAGAAGATACCA
TTGCCATACTAAAAGTTCTAAAAGACAAGCTTGAGGCGCACCATAAAGTAAAGATCACCGACAACGCGATAAAGGCTGCA
GTTTATTTGTCTGATCGCTACATCTCAGACCGCCATCTACCTGACAAGGCTATTGATTTACTAGACGAAGCATGCGCAAA
AGTACGGTTAAGAGCTTCAAGTGTTCCCAAAGAACTTAAAGAATTGGATCAAAAGATTGATGAATTGCAGAAGCAACTGA
GGTCAGCTGTAGATGCTAATGAATTTGAAAAAGCTGCACAACTTCGAGACGAAATAGCCAAGCTCAAAGAGGAAAGAGAA
GAGTTTGAAAAGAAGGTAAGGCACGCTTCCTCTAATGATCTTACAGTGACAGACCAAGAAGTAGCAGAGGTTGTGTCAGC
GTGGACAGGAATTCCTGTAACCCAGCTAGAGGAAAGCGAAAAGGAAAAACTAGCTAAACTGGAAGAAATTCTTCATCGTA
GGGTAGTGGGCCAAGATGAAGCCATTTCTGCTGTAGCTCAGGCAATTAGGCGCGCTAGGACGGGCTTGAAGGATCCAAAG
AGACCCATTGGCAGTTTCATATTCTTGGGTCCGACGGGCGTTGGTAAGACAGAACTGGCCAAAGCTTTAGCTGAAGTACT
TTTTGGCGATGAGTCGGCGCTAGTACGCTTTGACATGTCTGAATACATGGAGAAGCACACCGTAAGCAGACTCATAGGTT
CTCCGCCTGGTTACGTGGGATATGAAGAGGGAGGGCAACTCACCGAAGCAGTTCGCAGGCGTCCTTACAGTGTCATCTTA
TTCGACGAAATCGAGAAGGCTCACCCCGATATTCACAATTTGTTGCTGCAAGTGTTAGATGATGGACGGCTCACCGACGC
GAAGGGCCGTATCGTAGACTTTAAGAACACCATCATCATTATGACTAGCAACTTAGGAAGTCACATTCTAATGAATGCTG
CTCAAGAGGGTAGGCCTTTTGAGGAAGCTGAAAAAGAAGTTATGGATCTGCTCAAGAGTTACTTCAGACCAGAATTCCTA
AACAGGGTAGATGACATCGTGTTCTTCAAGCCGCTTACTATGGATGAAATAAAGGAGATCGCTAAGTTGCAGCTCTCATA
TGTGGCTCAGCGCCTTTCACAGCAACAGATATACGTGGAATTTACTGATGCCGCCATAGAAAACCTTGCTAAGGTAGGGT
TTGATCCAGAACTTGGAGCTAGGCCTCTTCGGAGAGCAATACAGAAAGAAATTGAGAACAGAATAGCCGAAAAAATGGTT
CTAGGAGAAGTTGCGCCAGGTGACCACATAAAGGTGGATTTCAAAGAGGGAAGTTTCACCGTTCAGAAAATTAGTAGCTA
A

Protein sequence :
MFDDIFQQFFGNEFSDLFPEFFERRKRDITDYLSSSSLSILQNAANLAGAAGYDELTPEHLAYALLQYEPLANVLVEHGV
NVEKIKEELEESLTPKGEAVSEVTVSPQLKSVLERAADMARNTFRGEATPEQLLFAILEDGGYAASILERNNLKLNNLMD
IIEEESRTRPSAGASPYQRGTQTATTELEKFGRDLTELARQGKLDPIVGRDSEIQRVLEILSRRTKNNPILIGDAGVGKT
AIVEGIAQRIASGDVPDALKGKRVIQLDIGSLVAGTKYRGEFEERMQKILDEVIKQKDKIILFIDEIHTIIGAGGAEGAV
DASNMLKPALARGDLHVIGATTIDEYRKYIEKDPAFERRFQPVYVPEPSLEDTIAILKVLKDKLEAHHKVKITDNAIKAA
VYLSDRYISDRHLPDKAIDLLDEACAKVRLRASSVPKELKELDQKIDELQKQLRSAVDANEFEKAAQLRDEIAKLKEERE
EFEKKVRHASSNDLTVTDQEVAEVVSAWTGIPVTQLEESEKEKLAKLEEILHRRVVGQDEAISAVAQAIRRARTGLKDPK
RPIGSFIFLGPTGVGKTELAKALAEVLFGDESALVRFDMSEYMEKHTVSRLIGSPPGYVGYEEGGQLTEAVRRRPYSVIL
FDEIEKAHPDIHNLLLQVLDDGRLTDAKGRIVDFKNTIIIMTSNLGSHILMNAAQEGRPFEEAEKEVMDLLKSYFRPEFL
NRVDDIVFFKPLTMDEIKEIAKLQLSYVAQRLSQQQIYVEFTDAAIENLAKVGFDPELGARPLRRAIQKEIENRIAEKMV
LGEVAPGDHIKVDFKEGSFTVQKISS

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
clpC YP_005163377.1 ATP-dependent Clp protease ATP-binding subunit Not tested Not named Protein 4e-176 57

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
COPRO5265_0843 YP_002247181.1 negative regulator of genetic competence ClpC/mecB VFG0079 Protein 0.0 53
COPRO5265_0843 YP_002247181.1 negative regulator of genetic competence ClpC/mecB VFG0080 Protein 9e-151 49