Gene Information

Name : thyA (KPK_0879)
Accession : YP_002236751.1
Strain : Klebsiella pneumoniae 342
Genome accession: NC_011283
Putative virulence/resistance : Unknown
Product : thymidylate synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0207
EC number : -
Position : 887733 - 888527 bp
Length : 795 bp
Strand : +
Note : ThyA; catalyzes formation of dTMP and 7,8-dihydrofolate from 5,10-methylenetetrahydrofolate and dUMP; involved in deoxyribonucleotide biosynthesis; there are 2 copies in some Bacilli, one of which appears to be phage-derived

DNA sequence :
ATGAAACAGTATCTTGATTTGATGCAGAAAGTGCTCACCGAGGGCACGCCAAAAAATGACCGCACCGGCACTGGCACGAT
CTCTATTTTCGGCCATCAGATGCGTTTTAACCTGCAGGAAGGCTTCCCGCTGGTGACCACCAAGCGCTGTCATTTACGCT
CCATCATCCATGAACTGCTGTGGTTCCTGCAGGGCGACACCAACATCGCCTATCTGCACGACAACAACGTCACCATCTGG
GACGAGTGGGCAGATGAAAATGGCGACCTGGGGCCGGTCTACGGCAAACAGTGGCGTTCCTGGCCTGCGCCGGACGGTCG
TCATATCGACCAGATCACCACGGTGATGAACCAACTGAAAAACGACCCGGACTCCCGCCGGATCATCGTCTCGGCGTGGA
ACGTCGGCGAGCTGGATAAAATGGCGCTGGCGCCGTGCCACGCCTTCTTCCAGTTCTACGTCGCTGACGGCAAGCTCTCC
TGCCAGCTGTATCAGCGCTCCTGCGACGTATTCCTCGGCCTGCCGTTCAATATCGCCAGCTACGCGCTGCTGGTGCATAT
GGTGGCGCAGCAGTGCGATCTGCAGGTCGGTGATTTCGTCTGGACCGGCGGCGACACCCATCTGTACAGCAACCATCTTG
AGCAGACCAACCTGCAGTTGAGCCGCGAACCGCGTCCGCTGCCGAAGCTGGTCATCAAACGCAAACCGGCGTCGATTTTC
GACTACCGTTTTGAAGACTTCGAGATTGAAGGTTACGATCCGCACCCGGGCATTAAAGCGCCGGTGGCGATTTAA

Protein sequence :
MKQYLDLMQKVLTEGTPKNDRTGTGTISIFGHQMRFNLQEGFPLVTTKRCHLRSIIHELLWFLQGDTNIAYLHDNNVTIW
DEWADENGDLGPVYGKQWRSWPAPDGRHIDQITTVMNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLS
CQLYQRSCDVFLGLPFNIASYALLVHMVAQQCDLQVGDFVWTGGDTHLYSNHLEQTNLQLSREPRPLPKLVIKRKPASIF
DYRFEDFEIEGYDPHPGIKAPVAI

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
thyA YP_001800914.1 thymidylate synthase Not tested Not named Protein 1e-88 67