Gene Information

Name : thiC (KPK_5298)
Accession : YP_002241065.1
Strain : Klebsiella pneumoniae 342
Genome accession: NC_011283
Putative virulence/resistance : Unknown
Product : thiamine biosynthesis protein ThiC
Function : -
COG functional category : H : Coenzyme transport and metabolism
COG ID : COG0422
EC number : -
Position : 5358774 - 5360669 bp
Length : 1896 bp
Strand : +
Note : required for the synthesis of the hydromethylpyrimidine moiety of thiamine

DNA sequence :
ATGTCTACTACCAAACTCACCCGTCGGGAACAACGCGAGCACGCGCAGCGATTCATTGATACGCTGGCAGGTACCGCTTT
TCCCAATTCACGCCGCATCTACGTTCACGGCTCACAAGCGGATATCCGCGTCCCGATGCGTGAAATTGAGCTCAGCCCGA
CCCTCGTCGGCGGCGATAAAGATAACCCCCGGTACGAAGCCAATGAACCGATCCCGGTATATGACACCTCCGGCCCTTAT
GGCGACCCGGATATTGGCATTGATGTCCGCCAGGGGCTGGCAAAGCTGCGCCAGCCGTGGATCGACGCGCGTAACGACTG
CGCTCCGCTCAGCGAACGCAGCTCGGCCTATACCAAAGCGCGGCTGGCCGATGACGGTCTCGATGAGCTGCGCTTCAGCG
GCCTGCTGACGCCCAAACGCGCCGTCGCCGGGAAATGCGTTACCCAACTGCACTACGCCCGCCAGGGGATCGTCACCCCG
GAGATGGAGTTCATCGCCATTCGCGAAAACATGGGTCGCGAACGTATCCGCAGCGAGGTTCTGCGCCAGCAGCATGCCGG
GGAAGGCTTCGGTGCCCGCCTGCCGGAAAACATTACCCCCGAGTTCGTCCGCGATGAAGTTGCCGCCGGACGCGCCATCA
TCCCCGCCAACATCAACCACCCGGAATCTGAGCCGATGATTATCGGCCGCAATTTCCTGGTGAAAGTGAATGCCAATATC
GGCAACTCGGCGGTGACCTCTTCCATCGAAGAGGAGGTGGAAAAACTGGTCTGGTCAACCCGCTGGGGCGCCGACACGGT
GATGGACCTCTCCACCGGCCGCTATATCCACGAAACCCGCGAGTGGATCCTGCGCAACAGCCCGGTGCCGATTGGTACCG
TCCCGATTTACCAGGCGCTGGAGAAGGTCAACGGCATTGCCGAGAACCTGACCTGGGAAGCCTTCCGCGATACCCTGCTG
GAACAGGCCGAACAGGGCGTCGACTACTTCACGATTCACGCCGGCGTACTGCTGCGCTACGTGCCGATGACCGCGAAGCG
CCTGACAGGTATCGTGTCGCGCGGTGGTTCCATCATGGCCAAGTGGTGCCTGTCGCACCATCAGGAAAACTTCCTCTACC
AGCACTTCCGCGAAATCTGCGAAATCTGCGCCGCCTATGACGTTTCGCTGTCCCTCGGCGATGGCCTGCGCCCCGGCTCC
ATTCAGGACGCCAACGACGAGGCGCAGTTTTCCGAGCTGCGCACCCTAGGCGAACTGACGAAAATCGCCTGGGAGTATGA
CGTACAGGTGATGATTGAAGGCCCCGGCCACGTGCCGATGCAGATGATCCGCCGCAATATGACCGAAGAGCTGGAGCATT
GCCACGAAGCGCCGTTCTATACCTTAGGCCCGCTCACCACCGACATCGCGCCGGGCTACGACCATTTCACTTCCGGTATC
GGCGCGGCGATGATCGGCTGGTTTGGCTGCGCGATGCTGTGCTACGTCACGCCAAAAGAGCATCTCGGCCTGCCCAACAA
AGAGGATGTAAAACAGGGGCTGATTACCTACAAAATCGCCGCCCACGCCGCCGACCTCGCGAAAGGCCACCCCGGGGCGC
AGATCCGCGACAACGCGATGTCCAAAGCGCGTTTCGAATTCCGCTGGGAAGACCAGTTCAACCTCGCGCTCGACCCCTTC
ACCGCGCGGGCCTATCACGATGAAACCCTGCCGCAGGAGTCCGGCAAGGTCGCCCATTTCTGCTCCATGTGCGGGCCGAA
ATTCTGTTCGATGAAAATCACCCAGGAAGTCCGCGACTACGCCGCGAAGCAAAATATCGAAGCTGGCATGGCCGATATGT
CGCATCACTTCCGCGCCCGTGGCGGCGAAATCTACCTGAAACAGGAGGAAGCCTGA

Protein sequence :
MSTTKLTRREQREHAQRFIDTLAGTAFPNSRRIYVHGSQADIRVPMREIELSPTLVGGDKDNPRYEANEPIPVYDTSGPY
GDPDIGIDVRQGLAKLRQPWIDARNDCAPLSERSSAYTKARLADDGLDELRFSGLLTPKRAVAGKCVTQLHYARQGIVTP
EMEFIAIRENMGRERIRSEVLRQQHAGEGFGARLPENITPEFVRDEVAAGRAIIPANINHPESEPMIIGRNFLVKVNANI
GNSAVTSSIEEEVEKLVWSTRWGADTVMDLSTGRYIHETREWILRNSPVPIGTVPIYQALEKVNGIAENLTWEAFRDTLL
EQAEQGVDYFTIHAGVLLRYVPMTAKRLTGIVSRGGSIMAKWCLSHHQENFLYQHFREICEICAAYDVSLSLGDGLRPGS
IQDANDEAQFSELRTLGELTKIAWEYDVQVMIEGPGHVPMQMIRRNMTEELEHCHEAPFYTLGPLTTDIAPGYDHFTSGI
GAAMIGWFGCAMLCYVTPKEHLGLPNKEDVKQGLITYKIAAHAADLAKGHPGAQIRDNAMSKARFEFRWEDQFNLALDPF
TARAYHDETLPQESGKVAHFCSMCGPKFCSMKITQEVRDYAAKQNIEAGMADMSHHFRARGGEIYLKQEEA

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
BJAB07104_00317 YP_008207782.1 Thiamine biosynthesis protein ThiC Not tested AbaR25 Protein 0.0 72
BJAB0868_00321 YP_008211647.1 Thiamine biosynthesis protein ThiC Not tested AbaR26 Protein 0.0 72
thiC YP_001598318.1 thiamine biosynthesis protein ThiC Not tested MDA Protein 0.0 71