Gene Information

Name : cusR (KPK_4903)
Accession : YP_002240684.1
Strain : Klebsiella pneumoniae 342
Genome accession: NC_011283
Putative virulence/resistance : Virulence
Product : DNA-binding transcriptional activator CusR
Function : -
COG functional category : T : Signal transduction mechanisms
COG ID : COG0745
EC number : -
Position : 4950268 - 4950951 bp
Length : 684 bp
Strand : -
Note : response regulator in two-component regulatory system with CusS; regulates the copper efflux system

DNA sequence : 
GTGAAGATTTTGATTGTCGAAGATGAGAAGAAAACCGGAGAGTACCTGACCAAAGGGCTCACCGAGGCCGGCTTCGTCGT
CGACCTGGCCGATAACGGCCTTAACGGCTATCACCTGGCAATGACCAGCGATTACGATCTGCTGATCCTCGACATCATGC
TGCCGGATGTGAACGGCTGGGATATCGTCCGCATGCTGCGCGCCGCCAATAAAGGCATGCCGATCCTGCTGCTCACCGCG
CTTGGCACTATTGAGCATCGGGTGAAGGGCCTGGAACTGGGCGCCGACGACTATCTGGTGAAGCCATTTGCTTTTGCGGA
GCTGCTGGCGCGAGTGCGGACCCTGCTGCGCCGTGGAGCGGCGGTCATCGTCGAAAGCCAGTTTCAGGCGGCGGATCTCA
GCGTCGATTTGGTCAGCCGCAAGGTGACGCGCGGCGCGACGCGTATCACCCTGACCAGTAAGGAATTCACTCTGCTGGAG
TTCTTCCTGCGCCATCAGGGCGAGGTGCTGCCGCGTTCGCTGATTGCCTCGCAGGTCTGGGATATGAATTTCGACAGCGA
CACTAACGCCATTGACGTGGCGGTGAAGCGGCTGCGCGCCAAAATTGATAACGACTTCGAGCCGAAGCTTATCCAGACCG
TGCGCGGCGTCGGCTATATGCTTGAGGTGCCGGATGGCCGCTAA

Protein sequence : 
MKILIVEDEKKTGEYLTKGLTEAGFVVDLADNGLNGYHLAMTSDYDLLILDIMLPDVNGWDIVRMLRAANKGMPILLLTA
LGTIEHRVKGLELGADDYLVKPFAFAELLARVRTLLRRGAAVIVESQFQAADLSVDLVSRKVTRGATRITLTSKEFTLLE
FFLRHQGEVLPRSLIASQVWDMNFDSDTNAIDVAVKRLRAKIDNDFEPKLIQTVRGVGYMLEVPDGR

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
copR NP_460069.2 transcriptional regulatory protein YedW Not tested SPI-5 Protein 2e-55 52
copR AAC33719.1 regulatory protein CopR Not tested SPI-5 Protein 2e-55 52

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
cusR YP_002240684.1 DNA-binding transcriptional activator CusR BAC0111 Protein 1e-100 96
cusR YP_002240684.1 DNA-binding transcriptional activator CusR BAC0347 Protein 3e-87 83
cusR YP_002240684.1 DNA-binding transcriptional activator CusR BAC0083 Protein 2e-70 63
cusR YP_002240684.1 DNA-binding transcriptional activator CusR BAC0638 Protein 3e-63 62
cusR YP_002240684.1 DNA-binding transcriptional activator CusR BAC0308 Protein 5e-63 59
cusR YP_002240684.1 DNA-binding transcriptional activator CusR BAC0197 Protein 4e-63 59
cusR YP_002240684.1 DNA-binding transcriptional activator CusR BAC0125 Protein 5e-65 56
cusR YP_002240684.1 DNA-binding transcriptional activator CusR AE000516.2.gene3505. Protein 4e-27 42

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
cusR YP_002240684.1 DNA-binding transcriptional activator CusR VFG0596 Protein 8e-56 52
cusR YP_002240684.1 DNA-binding transcriptional activator CusR VFG1390 Protein 9e-45 45