Gene Information

Name : murD (KPK_4649)
Accession : YP_002240440.1
Strain : Klebsiella pneumoniae 342
Genome accession: NC_011283
Putative virulence/resistance : Unknown
Product : UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase
Function : -
COG functional category : M : Cell wall/membrane/envelope biogenesis
COG ID : COG0771
EC number : -
Position : 4685867 - 4687183 bp
Length : 1317 bp
Strand : -
Note : UDP-N-acetylmuramoylalanine--D-glutamate ligase; involved in peptidoglycan biosynthesis; cytoplasmic; catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine during cell wall formation

DNA sequence :
ATGGCAGATTATCAGGGTAAAAAAGTCGTCATTATTGGGCTGGGTATGACCGGCCTGTCATGCGTGGACTTTTTCATGGC
GCGCGGCGTGACGCCGCGCGTGATGGACACCCGCGTCGCGCCTCCGGGGCTGGATAAATTACCCGAATCGGTCGAATGCC
ATGTCGGTGGACTCAATGATACCTGGCTGCTGGCGGCGGATCTGATTGTCGCCAGTCCCGGCATCGCGCTGGCCCATCCT
TCACTGAGCGCGGCAGCCGATGCAGGCGTAGAGATCGTTGGTGATATCGAACTGTTCTGCCGCGAGGCGCAGGCGCCGAT
TATCGCCATTACCGGCTCTAACGGCAAAAGCACTGTCACTACTCTGGTGGGCGAGATGGCGAAAGCGGCCGGGGTTAACG
TCGGCGTGGGCGGTAATATCGGCCTGCCGGCGCTGATGCTGCTGGACACCGATCGTGAGCTGTATGTGCTGGAGCTCTCC
AGCTTCCAGCTGGAAACGACCTCCAGCCTGCAGGCGGTGGCGGCAACCATCCTCAACGTGACTGAGGACCATATGGACCG
CTACCCGCTGGGGCTGCAGCAGTATCGCGCGGCGAAGCTGCGGATTTACGAGAATGCAAAAACCTGCGTGGTGAACGCGG
ACGATGCGCTCACGATGCCGGTACGCGGGGCGGACGATCGCTGCATCAGCTTTGGTGTCGATGTCGGTGACTACCACCTT
AACCGTCAGCAGGGCGAAACCTGGCTGCGCGTTAAAGGTGAGAAAGTCCTTAATGTGAAAGAGATGCCTCTCACCGGTCA
GCATAACTACAGCAACGCCCTGGCGGCACTGGCGCTGGCCGATGCCGCGGGCCTGCCGCGGGCCAGTAGCCTGAAGGCAT
TAACCACCTTTACTGGCCTGGCCCATCGCTTTCAGCTGGTGCTGGATCACAACGGCGTACGCTGGATTAACGACTCGAAG
GCAACCAACGTCGGCAGCACCGAGGCGGCGCTGAACGGCCTGCAGCTCGACGGCACGCTGTATCTGCTGCTGGGCGGCGA
CGGCAAGTCCGCTGATTTTACCCCGCTGAAGCGCTACCTCGGCGGCGATCGTATTCGCTTGTACTGTTTTGGTCGCGATG
GCGCCGAGCTCGCTGAGCTGCGTCCTGACGTGGCGGTACAAACTGAGACCATGGAACAGGCGATGCGTCAGATTGCATCT
CTGGTGAAAGCGGGCGACATGGTTCTCCTGTCGCCGGCGTGCGCCAGCCTGGATCAGTTTAAGAATTTTGAACAACGGGG
CGATATTTTTGCCCGTCTGGCGAAGGAGTTAGGTTGA

Protein sequence :
MADYQGKKVVIIGLGMTGLSCVDFFMARGVTPRVMDTRVAPPGLDKLPESVECHVGGLNDTWLLAADLIVASPGIALAHP
SLSAAADAGVEIVGDIELFCREAQAPIIAITGSNGKSTVTTLVGEMAKAAGVNVGVGGNIGLPALMLLDTDRELYVLELS
SFQLETTSSLQAVAATILNVTEDHMDRYPLGLQQYRAAKLRIYENAKTCVVNADDALTMPVRGADDRCISFGVDVGDYHL
NRQQGETWLRVKGEKVLNVKEMPLTGQHNYSNALAALALADAAGLPRASSLKALTTFTGLAHRFQLVLDHNGVRWINDSK
ATNVGSTEAALNGLQLDGTLYLLLGGDGKSADFTPLKRYLGGDRIRLYCFGRDGAELAELRPDVAVQTETMEQAMRQIAS
LVKAGDMVLLSPACASLDQFKNFEQRGDIFARLAKELG

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
BJAB07104_00311 YP_008207776.1 UDP-N-acetylmuramoylalanine-D-glutamate ligase Not tested AbaR25 Protein 2e-51 43
BJAB0868_00315 YP_008211641.1 UDP-N-acetylmuramoylalanine-D-glutamate ligase Not tested AbaR26 Protein 2e-51 43