Gene Information

Name : cadB (KPK_4093)
Accession : YP_002239896.1
Strain : Klebsiella pneumoniae 342
Genome accession: NC_011283
Putative virulence/resistance : Virulence
Product : lysine/cadaverine antiporter
Function : -
COG functional category : E : Amino acid transport and metabolism
COG ID : COG0531
EC number : -
Position : 4152713 - 4154047 bp
Length : 1335 bp
Strand : -
Note : antiporter protein responsible for lysine import and cadaverine export; member of the lysine-dependent acid resistance system 4 (AR4); inner membrane protein

DNA sequence :
ATGAGTTCTGCCAAGAAGATCGGGCTATTTGCCTGTACCGGTGTCGTCGCCGGTAATATGATGGGGAGCGGTATTGCATT
ATTACCTGCGAACCTGGCCAGCATCGGTGGTATTGCCATTTGGGGCTGGGTAATTTCAATTATTGGTGCGATGTCTCTGG
CTTATGTTTATGCCCGACTGGCCACTAAGAACCCGCAACAGGGTGGTCCAATTGCCTACGCCGGGGAAATATCTCCCGCA
TTCGGTTTCCAGACCGGTGTGCTTTATTATCATGCAAACTGGATTGGTAACCTGGCCATCGGGATTACCGCAGTTTCTTA
TCTCTCAACGTTCTTCCCAATTTTAAATAACCCGGTGCCAGCAGGTATTGCCTGTATTGCCATCGTGTGGATCTTTACTT
TCGTTAATATGCTCGGCGGGACCTGGGTCAGCCGTCTGACCACTATTGGTCTGGTACTGGTGCTTATTCCAGTGGTCATG
ACCGCGGTTGTCGGCTGGCACTGGTTTGATGTCGCCACCTATCAGGCGAACTGGAACACCTCCAGCACCACCGATAGCCA
CGCGGTCATTAAAAGTATCCTGCTCTGCCTGTGGGCCTTTGTTGGCGTCGAATCCGCCGCCGTGAGTACCGGGATGGTAA
AAAACCCGAAACGTACCGTCCCGCTGGCTACCATGCTGGGTACTGCGATGGCCGGTATCGTCTATATCGCCGCGACTCAG
GTTATCGCCGGTATGTATCCTGCTTCTCAGATGGCCGCGTCCGGTGCGCCGTTCGCGATTAGCGCCTCTACCATTCTCGG
CGGCTGGGCTGCTCCGATGGTTTCCGCTTTCACTGCCTTCGCTTGCCTGACTTCTCTGGGCTCGTGGATGATGCTGGTTG
GCCAGGCCGGTGTACGTGCCGCCAACGACGGTAACTTCCCGAAAGTGTATGGCGAAGTCGATAGCAACGGTATCCCGAAA
AAAGGCCTGCTGCTGGCGGCGGTGAAAATGACCGCGCTGATGGTGCTGATCACCCTGATGAACTCCGCCGGTGGTAAAGC
TTCTGACCTGTTCGGCGAACTGACCGGTATCGCGGTACTGCTGACCATGCTGCCTTACTTCTACTCCTGTGTTGACCTGA
TTCGTTTCGAAGGCATCAACATTCGTAACTTCGTTAGCCTGATTTGTTCGGTACTGGGTTGCGTGTTCTGCTTCATCGCG
CTGATGGGCGCAAGCTCCTTCGAACTGGCCGGCACCTTTATCGTTAGCCTGATTATCCTGATGTTCTACGGTCGCAAAAT
GCACCAGCGCCAGAACAACGCAACGGATAACAACAGCCCCGCTAACGCGCACTAA

Protein sequence :
MSSAKKIGLFACTGVVAGNMMGSGIALLPANLASIGGIAIWGWVISIIGAMSLAYVYARLATKNPQQGGPIAYAGEISPA
FGFQTGVLYYHANWIGNLAIGITAVSYLSTFFPILNNPVPAGIACIAIVWIFTFVNMLGGTWVSRLTTIGLVLVLIPVVM
TAVVGWHWFDVATYQANWNTSSTTDSHAVIKSILLCLWAFVGVESAAVSTGMVKNPKRTVPLATMLGTAMAGIVYIAATQ
VIAGMYPASQMAASGAPFAISASTILGGWAAPMVSAFTAFACLTSLGSWMMLVGQAGVRAANDGNFPKVYGEVDSNGIPK
KGLLLAAVKMTALMVLITLMNSAGGKASDLFGELTGIAVLLTMLPYFYSCVDLIRFEGINIRNFVSLICSVLGCVFCFIA
LMGASSFELAGTFIVSLIILMFYGRKMHQRQNNATDNNSPANAH

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
cadB NP_756989.1 lysine/cadaverine antiporter Not tested PAI II CFT073 Protein 0.0 94
cadB AAL67382.1 cadaverine/lysine antiporter Not tested PAI II CFT073 Protein 0.0 94
unnamed CAD66196.1 putative lysin/cadaverin transporter Virulence PAI III 536 Protein 4e-145 68

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
cadB YP_002239896.1 lysine/cadaverine antiporter VFG1671 Protein 2e-145 68