Gene Information

Name : KPK_3786 (KPK_3786)
Accession : YP_002239605.1
Strain : Klebsiella pneumoniae 342
Genome accession: NC_011283
Putative virulence/resistance : Resistance
Product : RND transporter hydrophobe/amphiphile efflux-1 (HAE1) family
Function : -
COG functional category : V : Defense mechanisms
COG ID : COG0841
EC number : -
Position : 3837050 - 3840115 bp
Length : 3066 bp
Strand : +
Note : identified by match to protein family HMM PF00873

DNA sequence :
ATGGACATTTCCCGTCAGTTTATTAACAACCCGACCCGCGTCTGGTTAGCCATTTTGCTGTTGGGGGTGGGTGGCCTGTT
CGCCCTGCTCAATATTGGCCGCCTGGAAGATCCCGCCTTCACCATCAAAACGGCGGTGATCGTCACCCACTACCCTGGCG
CGTCCGCTCAGCAGGTGGAGGAGGAGGTGACCCTGCCGCTGGAAAACGCGATTCAGCAGCTTCCCTCGCTGGATAACGTC
AGCTCCATCTCCTCGAATGGCTTATCGCAAATTACAGTGAATATTGCTTCGCAGTACCATTCCAGCGAACTGCCGCAAAT
CTGGGATGAGCTGCGTCGCCGCGTCGGTGACGCCAGCCGGCTTTTTCCCCCGGGGGTAGTCCCCTCCTTCGTCAATGATG
ACTTTGGCGATGTGTTTGGCTTTTTCTTCGCCATTTCGGGCGACAGTTTTACCAATCCTGAGCTGGTGCGCTATGCCGAG
CAGTTGCGCCGTGAGCTGGTGCTGGTGCCGGGCGTCGGCAAAGTCGCCATTGGCGGCGCGATTCCACAGCAGATCAATGT
TGATATCTCGCTGGCGAAAATGGCGGCGCGCGGTATTACGCTTAACCAGCTTGCCGCTATCCTGACCCGGCTCAACGTGG
TATCCAGCGCCGGGGAGATCCGCGCCGGCAGCGAATCGATCCGCCTTCACCCCACCGGGGAGTTTCAGAATATCGATGAA
CTGGGGGATCTTCTGGTCAGCCCTCATGGCGCCAGCGCCACCACCCGACTACGGGATATTGCCACGTTGTCGCGCGGGCT
GACCGACTCTCCCTCCAGTATCTATCATGCCAACGGCCGCCAGGCAGTGACCATGGGGGTCTCCTTTATCCCCGGGGTCA
ATGTCATTGACGTGGGGCATGCCCTCGAAGCCCGACTTCAGCAGATGGCCGCCGATAAACCGGCGGGTATCGACATCGCC
ATTTTTTACGATCAGGCGGCAGAGGTCGCCCACTCGGTCAATGGTTTTATTACCAACTTCCTGATGGCCCTGGCGATCGT
CGTCGGCGTGCTGCTGGTGTTCATGGGGGTGCGCAGCGGGATCATTATTGCTTTGTCGCTGGCGCTCAACGTCCTCGGCA
CTCTGCTTATCATGTATATCTGGGGGATCGAGTTACAGCGAATCTCCCTCGGGGCGCTGATCATCGCCCTGAGTATGTTG
GTGGACAATGCCATTGTCATTGTCGAAGGGGTGCTGATCGCCCGCCAGCAAGGATCTCCGCTGCTGGGCGCGATTAATTA
TGTGATCCGCCGCTCCGCCCTGCCGCTGCTCGGCGCCACCGTTATTGCCATCCTCGCCTTCGCGCCAATTGGCCTTTCCC
AGGACTCCACCGGGGAGTATTGCAAATCCCTGTTCCAGGTGCTGCTGATCTCCCTGATGCTCAGCTGGTTTTCCGCCCTG
ACCATCACGCCGGTGCTCATCAAGTGGTGGTTGTTTAAAAACGCCCCGTCGGCCGAGGCGCCGAAGGAAAAAGCCGATCC
CTACCGCGGCCGCTTCTATCGTGGCTATCAGCAGACGCTGCGAATACTGCTGCAGCAAAAGACCCTGACGCTGGTGCTGA
TGGGCGCGCTGTTAGCCGGGGCGATCTGGGGCTTCACCTTCGTCCGGCAGAATTTCTTTCCGTCATCGAATACGCCCATT
TTCTTTGTCGACCTGTGGTTGCCCTACGGTACCGATATTAACGCCACCGAGCAGATGACCCGCGATATTGAGCGGTCGAT
CGCCAGCCAGCCGGGGGTGGCTACCACCGTCTCCACCATTGGCCAGGGCAGTATGCGATTTATTCTCACCTACAGCGGGC
AGCGCCAGTACAGCAACTACGCGCAGATTATGGTGCGGATGGACGACCAGCGCAGTATCGCCCCCGTCACCCGCCACGTC
GAGGCCTGGATTGCCAGAAACTACCCGCAGGTGAACGCCAGCACCAAACGCATTATGTTCGGCCCGTCCGGCGATAGCGC
GATTGAAGTGCGCATTAAGGGCCCTGATCCGGATACTCTGCGCGCGCTGGCCAGTCAGGTGGGCGACATTCTCGCCGCGG
ATCCGGCGACCGACAGCGTACGTAACGACTGGCAGAACCGCAGCAAGGTGATCCGCCCGCAATACTCTCTGGCGTTGGGA
CGTGAGCTGGGGGTGGATAAACAGGATATTGATAGCGCGCTGGAGATGAATTTCTCCGGCAGTCGCGCCGGGTTATATCG
CGAGGGCGCCGACCTGCTGCCCGTTATCGTCCGTCCGCCGGAAGCAGAGCGACAGGATGCCAATCACCTGAATAACGTGC
TGGTCTGGAGCCAGAGCCGGCAGCAGTATATTCCGTTGAGTAACGTCATCCATGGCTTCTCGCTGGAGTGGGAAGATCCA
TTGATTCTCCGTCGCGATCGCACCCGCGTGCTTACCGTTCAGACCGACCCCAGCCCGCAAAGCGGCCAAACGTCGGGCGA
TATCCTTGCCAGGGTGAAACCACGCATTGACGCGCTGACGCTGCCGCATGGCTACCGCATCGAATGGGGCGGCGATGCGG
AGAACTCCAGTGAAGCGCAGCAAGGGCTGTTCACGACCCTGCCGCTTGGCTATCTGGTGATGTTTATCATTACGGTGCTG
ATGTTCAGTTCGCTGAAAAACGCTGTTGCCATCTGGCTGACCGTCCCGCTGGCGCTGATCGGCGTCACGCCCGGTTTTTT
GCTGACCGGCATCCCTTTCGGCTTTATGGCCTTAATCGGCCTGCTTAGCCTCAGCGGTATGCTGATCCGCAACGGCATTG
TGCTGGTGGAAGAGATAGAGCAACAAAAACAGGAGAAAGATCAAAGACAAGCAATCATTGATGCGGCAACCTCTCGTCTG
CGGCCGATCCTGCTGACCGCCTTTACCACTGTGCTTGGCCTTGCCCCGCTGCTGCGCGATGTCTTTTTCCAGAGTATGGC
GGTGGTGATCATGTTCGGCCTCGCCTTTGCCACCGTACTGACGCTACTGGTTCTGCCGGTAATTTACGCTTGCTTCCACC
ATAAGGATATGACGCCTCAACGATGA

Protein sequence :
MDISRQFINNPTRVWLAILLLGVGGLFALLNIGRLEDPAFTIKTAVIVTHYPGASAQQVEEEVTLPLENAIQQLPSLDNV
SSISSNGLSQITVNIASQYHSSELPQIWDELRRRVGDASRLFPPGVVPSFVNDDFGDVFGFFFAISGDSFTNPELVRYAE
QLRRELVLVPGVGKVAIGGAIPQQINVDISLAKMAARGITLNQLAAILTRLNVVSSAGEIRAGSESIRLHPTGEFQNIDE
LGDLLVSPHGASATTRLRDIATLSRGLTDSPSSIYHANGRQAVTMGVSFIPGVNVIDVGHALEARLQQMAADKPAGIDIA
IFYDQAAEVAHSVNGFITNFLMALAIVVGVLLVFMGVRSGIIIALSLALNVLGTLLIMYIWGIELQRISLGALIIALSML
VDNAIVIVEGVLIARQQGSPLLGAINYVIRRSALPLLGATVIAILAFAPIGLSQDSTGEYCKSLFQVLLISLMLSWFSAL
TITPVLIKWWLFKNAPSAEAPKEKADPYRGRFYRGYQQTLRILLQQKTLTLVLMGALLAGAIWGFTFVRQNFFPSSNTPI
FFVDLWLPYGTDINATEQMTRDIERSIASQPGVATTVSTIGQGSMRFILTYSGQRQYSNYAQIMVRMDDQRSIAPVTRHV
EAWIARNYPQVNASTKRIMFGPSGDSAIEVRIKGPDPDTLRALASQVGDILAADPATDSVRNDWQNRSKVIRPQYSLALG
RELGVDKQDIDSALEMNFSGSRAGLYREGADLLPVIVRPPEAERQDANHLNNVLVWSQSRQQYIPLSNVIHGFSLEWEDP
LILRRDRTRVLTVQTDPSPQSGQTSGDILARVKPRIDALTLPHGYRIEWGGDAENSSEAQQGLFTTLPLGYLVMFIITVL
MFSSLKNAVAIWLTVPLALIGVTPGFLLTGIPFGFMALIGLLSLSGMLIRNGIVLVEEIEQQKQEKDQRQAIIDAATSRL
RPILLTAFTTVLGLAPLLRDVFFQSMAVVIMFGLAFATVLTLLVLPVIYACFHHKDMTPQR

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
VC0395_A1355 YP_001217299.1 AcrB/AcrD/AcrF family transporter Not tested VPI-2 Protein 2e-166 41

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
KPK_3786 YP_002239605.1 RND transporter hydrophobe/amphiphile efflux-1 (HAE1) family BAC0428 Protein 0.0 50
KPK_3786 YP_002239605.1 RND transporter hydrophobe/amphiphile efflux-1 (HAE1) family BAC0519 Protein 0.0 49
KPK_3786 YP_002239605.1 RND transporter hydrophobe/amphiphile efflux-1 (HAE1) family BAC0526 Protein 0.0 47
KPK_3786 YP_002239605.1 RND transporter hydrophobe/amphiphile efflux-1 (HAE1) family BAC0425 Protein 1e-166 41