Gene Information

Name : entE (SG0600)
Accession : YP_002225686.1
Strain : Salmonella enterica 287/91
Genome accession: NC_011274
Putative virulence/resistance : Virulence
Product : enterobactin synthase subunit E
Function : -
COG functional category : Q : Secondary metabolites biosynthesis, transport and catabolism
COG ID : COG1021
EC number : -
Position : 647760 - 649343 bp
Length : 1584 bp
Strand : +
Note : bifunctional 2,3-dihydroxybenzoate-AMP ligase/S-dihydroxybenzoyltransferase; activates the carboxylate group of 2,3-dihydroxy-benzoate forming (2,3-dihydroxybenzoyl)adenylate then catalyzes the acylation of holo-entB with 2,3-dihydroxy-benzoate adenylate

DNA sequence : 
ATGCGTATACCTTTCACCCGTTGGCCGGATGAATTTGCCCGCCGTTATCGTGAAAAAGGCTACTGGCAAGACGTGCCGTT
GACCGATATTCTGACCCGCCACGCTGGCAGCGACAAGACGGCGGTCATTGAAGGCGAGCGCGCATTCAGCTATCGCCAGC
TCAACCAGGCCGCAGATAATCTGGCCTGCAGTTTACGCCGTCAGGGCATCAAACCTAGCGAAACCGCTCTGGTACAACTG
GGGAATGTACCAGAACTGTATATCACCTTTTTCGCCCTGTTGAAGCTTGGCGTAGCGCCCGTTCTGGCGCTGTTTAGCCA
TCAACGTACCGAACTTAACGCCTATGCGATGCAGATCGCGCCGACGCTGGTGATTGCCGATCGCCAACATACGCTGTTCG
CCGGGGAGGACTTTCTCAACACGTTTGTGGCTGAACACCGCTCTGTGCGGGTGGTGTTATTGCGCAACGACGACGGCGAT
CACAGCCTGGACGCGGCGATGCGGCAGGCGGCGGAAGATTTCACCGCCACGCCATCACCTGCTGACGAAGTGGCCTACTT
TCAGCTTTCCGGCGGTACTACCGGCACGCCAAAGCTTATTCCCCGTACCCATAACGACTATTACTACAGCGTGCGCCGTA
GCAATGAGATTTGCGGTTTTAACGAGGAGACGCGTTTTCTGTGCGCGATTCCCGCCGCGCATAACTACGCCATGAGTTCG
CCGGGCGCGCTGGGCGTCTTTCTTGCCAAAGGAACGGTAGTGCTGGCGACCGATCCCAGCGCCACGCTCTGTTTCCCGCT
GATCGAAAAACACCAGATTAATGCCACGGCGCTGGTGCCTCCCGCGGTCAGTCTATGGCTACAGGCTATCCAGGAGTGGG
GCGGTAATGCGCCGCTGGCGTCATTAAGGTTATTGCAGGTTGGCGGCGCGCGGCTTTCTGCGACGCTGGCCGCCCGTATT
CCGGCTGAAATTGGCTGTCAGTTGCAGCAGGTCTTCGGCATGGCGGAAGGGTTAGTGAACTATACCCGGCTGGACGATAG
TCCGGAACGGATTATCAATACCCAGGGAAGACCCATGTGTCCGGACGACGAAGTGTGGGTGGCGGATGCCGACGGGAATC
CACTGCCGCCGGGCGAGATTGGTCGTCTGATGACGCGCGGCCCCTATACTTTTCGCGGCTATTTCAACAGTCCGCTACAC
AATGCCAGCGCCTTTGACGCCAACGGTTTTTACTGTTCCGGCGATCTGATCTCCATTGATCAAGACGGTTACATCACCGT
TCACGGGCGTGAAAAAGATCAGATCAATCGGGGCGGCGAGAAGATAGCCGCCGAAGAGATAGAAAACCTGTTACTGCGCC
ACCCAGCGGTGATCCATGTGGCGCTGGTCAGCATGGAAGATGAACTGCTGGGAGAAAAAAGTTGCGCATATCTGGTGGTA
AAAGAGCCGCTGCGAGCGGTACAGGTACGCCGTTTCCTGCGAGAGCAGGGCGTGGCGGAATTTAAATTACCGGATCGCGT
AGAGTGCGTTGCGTCACTGCCGCTGACGCCGGTTGGTAAAGTCGATAAAAAACAATTACGCTAG

Protein sequence : 
MRIPFTRWPDEFARRYREKGYWQDVPLTDILTRHAGSDKTAVIEGERAFSYRQLNQAADNLACSLRRQGIKPSETALVQL
GNVPELYITFFALLKLGVAPVLALFSHQRTELNAYAMQIAPTLVIADRQHTLFAGEDFLNTFVAEHRSVRVVLLRNDDGD
HSLDAAMRQAAEDFTATPSPADEVAYFQLSGGTTGTPKLIPRTHNDYYYSVRRSNEICGFNEETRFLCAIPAAHNYAMSS
PGALGVFLAKGTVVLATDPSATLCFPLIEKHQINATALVPPAVSLWLQAIQEWGGNAPLASLRLLQVGGARLSATLAARI
PAEIGCQLQQVFGMAEGLVNYTRLDDSPERIINTQGRPMCPDDEVWVADADGNPLPPGEIGRLMTRGPYTFRGYFNSPLH
NASAFDANGFYCSGDLISIDQDGYITVHGREKDQINRGGEKIAAEEIENLLLRHPAVIHVALVSMEDELLGEKSCAYLVV
KEPLRAVQVRRFLREQGVAEFKLPDRVECVASLPLTPVGKVDKKQLR

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
irp5 CAA73130.1 Irp5 protein Virulence HPI Protein 1e-88 42
irp5 YP_001006819.1 yersiniabactin siderophore biosynthetic protein Virulence HPI Protein 2e-88 42
ybtE AAA93464.1 yersiniabactin 2,3-dihydoxybenzoate-AMP ligase Virulence HPI Protein 8e-89 41
ybtE YP_853079.1 yersiniabactin siderophore biosynthetic protein Virulence PAI IV APEC-O1 Protein 1e-88 41
irp5 YP_002346898.1 yersiniabactin siderophore biosynthetic protein Virulence HPI Protein 1e-88 41
ybtE NP_669710.1 salicyl-AMP ligase Virulence HPI Protein 1e-88 41
ybtE NP_993003.1 yersiniabactin siderophore biosynthetic protein Virulence HPI Protein 1e-88 41
ybtE YP_070120.1 yersiniabactin siderophore biosynthetic protein Virulence HPI Protein 1e-88 41
ybtE CAA21394.1 - Virulence HPI Protein 1e-88 41

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
entE YP_002225686.1 enterobactin synthase subunit E VFG0932 Protein 0.0 87
entE YP_002225686.1 enterobactin synthase subunit E VFG0168 Protein 1e-114 46
entE YP_002225686.1 enterobactin synthase subunit E VFG1817 Protein 4e-88 42