Gene Information

Name : Lferr_2107 (Lferr_2107)
Accession : YP_002220522.1
Strain : Acidithiobacillus ferrooxidans ATCC 53993
Genome accession: NC_011206
Putative virulence/resistance : Resistance
Product : mercuric reductase
Function : -
COG functional category : C : Energy production and conversion
COG ID : COG1249
EC number : -
Position : 2101066 - 2102709 bp
Length : 1644 bp
Strand : +
Note : TIGRFAM: mercuric reductase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; pyridine nucleotide-disulphide oxidoreductase dimerisation region; FAD dependent oxidoreductase; Heavy metal transport/detoxification protein; KEGG: ppw:PputW6

DNA sequence :
ATGACCGAGAACGCGCCCACCGAACTCGCTATCACTGGCATGACCTGCGACGGTTGCGCCGCGCATGTGCGCAAAGCACT
CGAAGGCGTGCCCGGCGTACGCGAGGCGCAGGTGTCCTACCCGGATGCCACGGCCCGGGTCGTGCTGGAGGGCGAGGTGC
CGATGCAGCGGCTAATCAAGGCGGTGGTTGCAAGTGGCTATGGTGTGCATCCACGGAGCGACGGTGCCTCCTCCACAAAC
GATGGACAGGAGCTACACATCGCTGTGATCGGCAGCGGCGGAGCGGCGATGGCGTGCGCATTGAAGGCTGTCGAGCGGGG
CGCGCGCGTGACGCTGATCGAACGCAGCACCATCGGCGGCACCTGCGTGAACATCGGTTGCGTGCCGTCCAAGATCATGA
TCCGCGCCGCCCATATCGCCCACCTGCGCCGGGAAAGCCCATTCGATGGCGGCATCCAGGCGGTCGCGCCGACCATCCAG
CGCACAGCGCTGCTGGTCCAACAGCAGGCCCGTGTCGATGAACTGCGTCACGCCAAGTACGAAGGCATCCTGGACGGCAA
CCCGGCCATCACCGTTCTGCGCGGTGAAGCGCGTTTCAAGGACAGCCGGAGTGTTGTCGTCCATTTGAACGATGGTGGCG
AGCGCGTCGTAATGTTCGACCGCTGCCTGGTTGCCACGGGCGCCAGTCCGGCCGTGCCGCCGATTCCCGGCTTGAAAGAC
ACTCCTTATTGGACCTCCACCGAAGGGCTGGTCAGCGAATCGATCCCCGAGCGTCTGGCCGTGATCGGCTCGTCGGTGGT
GGCGCTGGAACTGGCGCAAGCCTTCGCCCGGCTCGGCAGCCATGTGACGATCCTGGCGCGCGGCACCTTGTTCCTCCGGG
AAGACCCGGCCATCGGTGAGGCCATCACGGCGGCGTTTCGCGCCGAAGGCATCGAGGTGCTGGAGCACACCCAGGCCAGC
CAGGTCGCTTATGCGGATGGCGAATTTGTGCTAGCCACCGGGCACGGCGAACTGCGCGCCGATAAGCTGCTGGTCGCCAC
TGGTCGCGCACCGAACACACGCCGCCTGAATCTGGAAGCGGCGGGCGTGGCCATCAATGCGCAAGGGGCCATCGTCATCG
ACCAGGGTATGCGCACGAACAGCCCGAACATTTACGCCGCTGGCGACTGCACCGACCAGCCGCAATTCGTCTACGTGGCG
GCAGCGGCCGGCACCCGTGCGGCCATCAACATGATGGGCGGTAGTGCAGCCCTGGACTTGACGGCGATGCCAGCCGTGGT
GTTCACCGATCCGCAAGTGGCGACTGTGGGTTACAGCGGCGCGGAAGCGCATCGCGACGGCATCGAAACCGACAGCCGCA
CGCTGACGCTCGACAACGTGCCGCGGGCGCTCGCCAATTTCAATACACGCGGCTTCATCAAGCTGGTAGCCGAAGTGGGC
AGTGGTCGCCTAATCGGCGTGCAGGTGGTCGCCCCGGAAGCGGGCGAGCTGATCCAGACTGCCGCGCTGGCGATTCGTAA
CCGGATGACGGTACAGGAACTGGCTGACCAGTTGTTTCCCTACCTGACGATGGTCGAAGGGCTGAAGCTTGCTGCCCAGA
CCTTCACCAGGGATGTGAAGCAGTTGTCCTGCTGTGCGGGTTGA

Protein sequence :
MTENAPTELAITGMTCDGCAAHVRKALEGVPGVREAQVSYPDATARVVLEGEVPMQRLIKAVVASGYGVHPRSDGASSTN
DGQELHIAVIGSGGAAMACALKAVERGARVTLIERSTIGGTCVNIGCVPSKIMIRAAHIAHLRRESPFDGGIQAVAPTIQ
RTALLVQQQARVDELRHAKYEGILDGNPAITVLRGEARFKDSRSVVVHLNDGGERVVMFDRCLVATGASPAVPPIPGLKD
TPYWTSTEGLVSESIPERLAVIGSSVVALELAQAFARLGSHVTILARGTLFLREDPAIGEAITAAFRAEGIEVLEHTQAS
QVAYADGEFVLATGHGELRADKLLVATGRAPNTRRLNLEAAGVAINAQGAIVIDQGMRTNSPNIYAAGDCTDQPQFVYVA
AAAGTRAAINMMGGSAALDLTAMPAVVFTDPQVATVGYSGAEAHRDGIETDSRTLTLDNVPRALANFNTRGFIKLVAEVG
SGRLIGVQVVAPEAGELIQTAALAIRNRMTVQELADQLFPYLTMVEGLKLAAQTFTRDVKQLSCCAG

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
merA ACN81005.1 MerA Hg(II) mercuric ion reductase Not tested AbaR5 Protein 0.0 80
merA CAJ77060.1 Mercuric ion reductase Not tested AbaR1 Protein 0.0 80
merA ABQ57371.1 MerA Not tested SGI1 Protein 0.0 79
merA AGK07021.1 MerA Not tested SGI1 Protein 0.0 79
merA AGK07079.1 MerA Not tested SGI1 Protein 0.0 79
merA AFG30120.1 MerA Not tested PAGI-2 Protein 0.0 78
merA YP_006098387.1 mercuric ion reductase Not tested Tn2411 Protein 0.0 78
merA AET25397.1 MerA Not tested PAGI-2(C) Protein 0.0 78
merA AAN62178.1 mercuric (Hg(II)) reductase Not tested PAGI-2(C) Protein 0.0 76
unnamed ABR13401.1 mercuric reductase Not tested PAGI-5 Protein 0.0 73
SE0085 NP_763640.1 dihydrolipoamide dehydrogenase Not tested SCCpbp4 Protein 4e-93 41
merA BAB47642.1 mercuric reductase Not tested Type-III SCCmec Protein 3e-93 41

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
Lferr_2107 YP_002220522.1 mercuric reductase BAC0653 Protein 0.0 81
Lferr_2107 YP_002220522.1 mercuric reductase BAC0652 Protein 0.0 79
Lferr_2107 YP_002220522.1 mercuric reductase BAC0650 Protein 4e-174 66
Lferr_2107 YP_002220522.1 mercuric reductase BAC0651 Protein 2e-93 41
Lferr_2107 YP_002220522.1 mercuric reductase BAC0224 Protein 7e-91 41