Gene Information

Name : Lferr_0209 (Lferr_0209)
Accession : YP_002218675.1
Strain : Acidithiobacillus ferrooxidans ATCC 53993
Genome accession: NC_011206
Putative virulence/resistance : Resistance
Product : heavy metal translocating P-type ATPase
Function : -
COG functional category : P : Inorganic ion transport and metabolism
COG ID : COG2217
EC number : -
Position : 197318 - 199225 bp
Length : 1908 bp
Strand : +
Note : TIGRFAM: ATPase, P-type (transporting), HAD superfamily, subfamily IC; cadmium-translocating P-type ATPase; heavy metal translocating P-type ATPase; PFAM: Haloacid dehalogenase domain protein hydrolase; E1-E2 ATPase-associated domain protein; KEGG: lpn:lp

DNA sequence :
ATGGCGTGCTCGTGCTCCGCTTCGCTCCCGCTGACCATGCCACGGCCGTGGAAAAACCCGCAAGTCGTGACCTCGTCCGC
TTCCGGGGTACTGCTCGCGTTGGGCTTCGTCGGCGGCTACCTGGGCCTGTCCCACGCCGCCGAGGTTTTGTTTTACGTGG
CTGCGGTCGTCATCGGCGGCTATTACTTCGGCCGGGAGGCGCTGGAGGAATTGATCAAGGAGCGTGCGGTTGGCATCGAA
CTGCTGATGTCCGTCGCGGCCCTCGTGGCCGGCGTGATGGGGCAGTGGCTGGAAGCCGCCACGCTGGTATTCCTTTATTC
CATCTCCGAGGCGGCGGAAGGCTACACGGCCGAACGTACGCGGCACGCCGTGCGGGCACTGATGGAGCTGGCGCCGAAGA
CCGCCCTGGTGCGCCGCGACGGCCAGGAGTCGCGCATCCCCGTCGAACAGTTGCGGGTGGGAGATATCTTCATCGTCCTG
CCCGGGGAATCGGTTGCCACCGACGGCGACGTGACCGACGGCCAGTCTGCGGTCAACCAGGCGCCGGTGACGGGAGAATC
CGTTCCGGTGGAGAAATCCCCGGGCGGCAAGGTCTTCGCCGCCAGCATCAACGGGGAAGGCGCGCTGACGGTACGCGTGA
CCAAGGCGTTCGCCGACAGCACGCTGTCCCGCATCATCCATCTGGTCGAAGCGGCGCAGGCCAGCAAGGGGCGCAGCCAG
CGCTTCATCGAGCGCTTCGGCAAACGCTACAGCCCGGCTGTTCTAGGCATCGGCATCCTGATCGCCCTGCTGCCACCGCT
GTTCGGGCTGCCGTGGGAGGATTGGCTGACCCGCGCGACGGTTTTCGTCGTGGCGGCGGCGCCCTGCGCCCTGGTGATCT
CGATTCCCATTACCCTGGTCGCGGCCCTGGGCACGGCCGGCCGCAACGGCCTGCTTATCAAGGGCGGCATCCATCTGGAG
AACCTCGCCCGAGTGAAAGTCGTGGCGCTCGACAAGACGGGCACCCTCACGATGGGACGCCCCGAGGTCACGGACGTGCT
GGCGTTCTGGGGGCACGACGAGCGCGAGGTGCTGGAGGCCGCCGCGGCGCTGGAGTCCCGCTCGCAACATCCCTTGGCGC
AGGCCATCGTGCGCCGCGCCCAGGCAATCGGCCTCGAACCGGCGCCAGCCGAGAATTTCCGCTCCCGTACCGGCGCGGGC
GCCCAGGGGGTGGTGGGCGGACGGGAGTTTTATATAGGCAGTCCAAAACTGTTCGCCGACCAGGGCGTTCCGGTTGCCGA
GGTGATGGACAAGGTTCAACACCTGCAAAGCCAGGGCAAGACCGTGGTGATGCTGGGGACCCATTTCTCGATCCAGGCAT
TATTTGCCATCGCTGACCCCTTGCGCCCCGAGGCGGCGGACGCCATCGCCGAACTGAAGCGCGCCGGGATCGAGCGGGTG
GTCATGCTGACCGGCGACAATCCCCTGGCCGCCGCCGCCATTGCCGAACAGGTTGGGATCGACGAGGTCCATGCCGAGCT
TTCTCCCGAGGACAAGACCCGCAAGGTGGCCGAACTGGAAGCGAGGTACGGCAAGGTGCTGATGGTGGGCGACGGCGTCA
ACGACGCGCCGGCGCTCGCCGCCGCTCACGTGGGCATCGCTATGGGAGCTGCTGGTACCGACGTGGCCCTGGAGACGGCG
GACGTGGCGCTCATGAGCGACAACCTGTCGCGCCTGCCCTACCTCATCCGATTCAGCCGGCGGACGTGGCGCGTGGTGCT
GCAAAACCTGGCGCTTTCCGTGGTGGTGATCGGCTCGCTCATCGCCGGGGCGGTGACGGGTTACTTCACGCTTCCCATCG
CAGTCATCGCGCACGAGATCAGCGAGTTCGTCGTGATCGCGAGCGGGCTGCGCATGCTCAGGACGTAA

Protein sequence :
MACSCSASLPLTMPRPWKNPQVVTSSASGVLLALGFVGGYLGLSHAAEVLFYVAAVVIGGYYFGREALEELIKERAVGIE
LLMSVAALVAGVMGQWLEAATLVFLYSISEAAEGYTAERTRHAVRALMELAPKTALVRRDGQESRIPVEQLRVGDIFIVL
PGESVATDGDVTDGQSAVNQAPVTGESVPVEKSPGGKVFAASINGEGALTVRVTKAFADSTLSRIIHLVEAAQASKGRSQ
RFIERFGKRYSPAVLGIGILIALLPPLFGLPWEDWLTRATVFVVAAAPCALVISIPITLVAALGTAGRNGLLIKGGIHLE
NLARVKVVALDKTGTLTMGRPEVTDVLAFWGHDEREVLEAAAALESRSQHPLAQAIVRRAQAIGLEPAPAENFRSRTGAG
AQGVVGGREFYIGSPKLFADQGVPVAEVMDKVQHLQSQGKTVVMLGTHFSIQALFAIADPLRPEAADAIAELKRAGIERV
VMLTGDNPLAAAAIAEQVGIDEVHAELSPEDKTRKVAELEARYGKVLMVGDGVNDAPALAAAHVGIAMGAAGTDVALETA
DVALMSDNLSRLPYLIRFSRRTWRVVLQNLALSVVVIGSLIAGAVTGYFTLPIAVIAHEISEFVVIASGLRMLRT

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
SE0075 NP_763630.1 cadmium resistance protein B Not tested SCCpbp4 Protein 7e-104 45
cadA BAC57487.1 Probable cadmium-transporting ATPase (Cadmium efflux ATPase) Not tested Type-IIIinv SCCmec Protein 2e-105 44
unnamed BAB47609.1 cadmium resistance protein B Not tested Type-III SCCmec Protein 2e-105 44

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
Lferr_0209 YP_002218675.1 heavy metal translocating P-type ATPase BAC0100 Protein 7e-78 46
Lferr_0209 YP_002218675.1 heavy metal translocating P-type ATPase BAC0298 Protein 3e-93 46
Lferr_0209 YP_002218675.1 heavy metal translocating P-type ATPase BAC0092 Protein 3e-92 45
Lferr_0209 YP_002218675.1 heavy metal translocating P-type ATPase BAC0124 Protein 1e-81 44