Gene Information

Name : tpx (SeAg_B1468)
Accession : YP_002146347.1
Strain : Salmonella enterica SL483
Genome accession: NC_011149
Putative virulence/resistance : Virulence
Product : thiol peroxidase
Function : -
COG functional category : O : Posttranslational modification, protein turnover, chaperones
COG ID : COG2077
EC number : 1.11.1.-
Position : 1427043 - 1427549 bp
Length : 507 bp
Strand : -
Note : antioxidant activity; thioredoxin-dependent thiol peroxidase; forms homodimers in solution; shows substrate specificity to alkyl hydroperoxides; periplasmic protein

DNA sequence : 
ATGTCACAGACTGTACATTTCCAGGGTAACCCGGTCACCGTTGCCAACGTTATTCCGCAGGCTGGTAGCAAAGCACAGGC
TTTTACTCTTGTCGCAAAAGATTTGTCTGACGTTTCCCTCAGCCAATATGCAGGCAAACGCAAAGTGCTGAATATTTTCC
CAAGCATTGATACTGGCGTATGCGCCGCATCAGTTCGTAAGTTTAATCAACTGGCCACAGAAGTGGAGAATACCGTCGTA
TTGTGCGTTTCTGCTGACCTGCCTTTTGCACAGTCGCGTTTTTGCGGCGCGGAAGGCCTGAGCAACGTTATTACGCTTTC
CACTCTGCGTAATAACGAGTTTCTGAAAAACTACGGCGTCGAAATCGTTGACGGCCCGCTGAAAGGTTTGGCGGCGCGCG
CAGTCATCGTGCTTGACGAAAACGACAACGTTATTTTCAGCCAGTTGGTGGATGAAATCACCCACGAGCCGGATTACGAC
GCCGCGCTTAATGTCCTGAAGGCATAA

Protein sequence : 
MSQTVHFQGNPVTVANVIPQAGSKAQAFTLVAKDLSDVSLSQYAGKRKVLNIFPSIDTGVCAASVRKFNQLATEVENTVV
LCVSADLPFAQSRFCGAEGLSNVITLSTLRNNEFLKNYGVEIVDGPLKGLAARAVIVLDENDNVIFSQLVDEITHEPDYD
AALNVLKA

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
tpx NP_230472.1 thiol peroxidase Virulence VPI-1 Protein 1e-34 49
tagD AAK20781.1 toxR-activated gene D protein Virulence VPI Protein 1e-34 49
tagD AAK20751.1 toxR-activated gene D protein Virulence VPI Protein 2e-34 48
tpx YP_001216305.1 thiol peroxidase Not tested VPI-1 Protein 3e-34 48

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
tpx YP_002146347.1 thiol peroxidase VFG0087 Protein 4e-35 49