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Name : covR (Sez_1666) Accession : YP_002124010.1 Strain : Streptococcus equi MGCS10565 Genome accession: NC_011134 Putative virulence/resistance : Virulence Product : TCS response regulator CovR-like Function : - COG functional category : T : Signal transduction mechanisms COG ID : COG0745 EC number : - Position : 1710413 - 1711099 bp Length : 687 bp Strand : - Note : similar to ref|NP_802877.1| two-component response regulator (CsrR/CovR) [Streptococcus pyogenes SSI-1]; Member of the two-component regulatory system CovR/CovS involved in the regulation of multiple virulence factors. DNA sequence : ATGACAAAGAAAATTTTAATTATCGAAGATGAAAAGAATCTTGCAAGATTTGTTTCGCTTGAGCTACAACATGAGGGTTA CGAGGTGACCGTCGAGGTTAATGGTCGTGAGGGCTTGGAGACAGCCCTAGAGAAGGACTTTGACTTAATCCTTCTTGATT TGATGCTTCCTGAGATGGACGGATTTGAAGTGACACGTCGATTGCAAACAGAAAAAACGACTTACATCATGATGATGACT GCGCGTGACTCTATTATGGACGTTGTAGCTGGCTTGGATCGTGGTGCTGACGATTACATCGTGAAGCCATTTGCCATTGA GGAATTGCTGGCGCGTATTCGTGCTATCTTCCGTCGTCAGGACATTGAGTCAGAGAAAAAGACTCCTAGTCAAGGCGTTT ACCGCGACTTAGTCTTAAACCCTCAAAACCGCTCTGTCAATCGCGGTGATGACGAGATTTCACTGACTAAGCGTGAATAT GACCTGCTTAATATTTTGATGACAAACATGAATCGTGTCATGACTCGTGAGGAGCTCTTGTCTAACGTTTGGAAATATGA CGAGGCTGTTGAAACTAACGTTGTTGATGTTTATATTCGTTACCTTCGTGGGAAGATCGATATCCCTGGGAAAGAGTCTT ACATTCAAACTGTTCGTGGAATGGGTTATGTGATTCGCGAGAAATAA Protein sequence : MTKKILIIEDEKNLARFVSLELQHEGYEVTVEVNGREGLETALEKDFDLILLDLMLPEMDGFEVTRRLQTEKTTYIMMMT ARDSIMDVVAGLDRGADDYIVKPFAIEELLARIRAIFRRQDIESEKKTPSQGVYRDLVLNPQNRSVNRGDDEISLTKREY DLLNILMTNMNRVMTREELLSNVWKYDEAVETNVVDVYIRYLRGKIDIPGKESYIQTVRGMGYVIREK |
| Gene | GenBank Accn | Product | Virulance or Resistance | PAI or REI | Alignment Type | E-val | Identity |
| copR | NP_460069.2 | transcriptional regulatory protein YedW | Not tested | SPI-5 | Protein | 1e-36 | 43 |
| copR | AAC33719.1 | regulatory protein CopR | Not tested | SPI-5 | Protein | 3e-36 | 43 |
| c3565 | NP_755440.1 | response regulator | Not tested | PAI I CFT073 | Protein | 2e-32 | 41 |
| Gene | GenBank Accn | Product | ID of source DB | Alignment Type | E-val | Identity |
| covR | YP_002124010.1 | TCS response regulator CovR-like | HE999704.1.gene1528. | Protein | 1e-59 | 61 |
| covR | YP_002124010.1 | TCS response regulator CovR-like | NC_003923.1003417.p0 | Protein | 3e-51 | 53 |
| covR | YP_002124010.1 | TCS response regulator CovR-like | NC_013450.8614146.p0 | Protein | 3e-51 | 53 |
| covR | YP_002124010.1 | TCS response regulator CovR-like | NC_002951.3238224.p0 | Protein | 3e-51 | 53 |
| covR | YP_002124010.1 | TCS response regulator CovR-like | NC_007793.3914065.p0 | Protein | 3e-51 | 53 |
| covR | YP_002124010.1 | TCS response regulator CovR-like | NC_002758.1121390.p0 | Protein | 3e-51 | 53 |
| covR | YP_002124010.1 | TCS response regulator CovR-like | NC_010079.5776364.p0 | Protein | 3e-51 | 53 |
| covR | YP_002124010.1 | TCS response regulator CovR-like | NC_002952.2859858.p0 | Protein | 3e-51 | 53 |
| covR | YP_002124010.1 | TCS response regulator CovR-like | NC_007622.3794948.p0 | Protein | 3e-51 | 53 |
| covR | YP_002124010.1 | TCS response regulator CovR-like | AE015929.1.gene1106. | Protein | 4e-49 | 53 |
| covR | YP_002124010.1 | TCS response regulator CovR-like | BAC0125 | Protein | 3e-36 | 43 |
| covR | YP_002124010.1 | TCS response regulator CovR-like | NC_012469.1.7685629. | Protein | 4e-38 | 42 |
| covR | YP_002124010.1 | TCS response regulator CovR-like | HE999704.1.gene2815. | Protein | 2e-38 | 42 |
| covR | YP_002124010.1 | TCS response regulator CovR-like | AE016830.1.gene1681. | Protein | 1e-39 | 41 |
| covR | YP_002124010.1 | TCS response regulator CovR-like | BAC0197 | Protein | 9e-33 | 41 |
| Gene | GenBank Accn | Product | ID of source DB | Alignment Type | E-val | Identity |
| covR | YP_002124010.1 | TCS response regulator CovR-like | VFG1390 | Protein | 1e-41 | 43 |
| covR | YP_002124010.1 | TCS response regulator CovR-like | VFG0596 | Protein | 4e-37 | 43 |
| covR | YP_002124010.1 | TCS response regulator CovR-like | VFG1702 | Protein | 9e-33 | 41 |
| covR | YP_002124010.1 | TCS response regulator CovR-like | VFG1389 | Protein | 1e-35 | 41 |
