Gene Information

Name : guaA (SeHA_C2766)
Accession : YP_002046570.1
Strain : Salmonella enterica SL476
Genome accession: NC_011083
Putative virulence/resistance : Unknown
Product : GMP synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0519
EC number : 6.3.5.2
Position : 2679482 - 2681059 bp
Length : 1578 bp
Strand : -
Note : contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway

DNA sequence :
ATGACGGAAAACATTCATAAGCATCGCATCCTCATTCTGGACTTCGGTTCTCAGTACACTCAACTGGTTGCGCGCCGCGT
GCGTGAGCTGGGTGTTTACTGCGAACTGTGGGCGTGGGATGTGACAGAAGCACAAATTCGTGACTTCAACCCAAGCGGCA
TTATTCTTTCCGGCGGCCCGGAAAGCACCACCGAAGAAAACAGCCCGCGCGCGCCGCAGTATGTCTTTGAAGCAGGCGTG
CCGGTATTTGGCGTTTGCTATGGTATGCAGACCATGGCGATGCAGCTTGGCGGTCATGTAGAAGGTTCTAATGAGCGTGA
ATTTGGTTATGCGCAGGTCGAAGTGCTGACCGACAGCGCGCTGGTTCGCGGTATTGAAGATTCCCTGACCGCAGACGGCA
AACCGCTGCTGGACGTGTGGATGAGCCACGGCGATAAAGTGACGGCGATTCCGTCCGACTTCGTGACTGTCGCCAGCACC
GAGAGCTGTCCGTTCGCCATTATGGCCAACGAAGAAAAACGCTTCTACGGCGTACAGTTCCACCCGGAAGTGACCCACAC
CCGCCAGGGTATGCGCATGCTGGAGCGTTTTGTGCGTGATATCTGCCAGTGTGAAGCCCTGTGGACGCCGGCGAAGATCA
TCGACGACGCCGTGGCGCGCATTCGCGAGCAGGTAGGCGACGATAAAGTGATCCTCGGTCTCTCCGGCGGTGTGGATTCT
TCCGTAACCGCAATGCTGCTGCACCGCGCGATCGGTAAAAATCTGACCTGTGTATTCGTCGACAACGGCCTGCTGCGTCT
CAACGAAGCCGAGCAGGTGATGGACATGTTTGGCGACCATTTTGGTCTGAACATTGTTCACGTACCGGCAGAAGATCGTT
TCCTGTCAGCGCTGGCTGGCGAAAACGATCCAGAAGCCAAGCGTAAGATCATTGGCCGTGTTTTTGTGGAAGTGTTCGAC
GAAGAAGCGCTGAAACTGGAAGACGTGAAATGGCTGGCGCAGGGCACCATCTACCCTGACGTTATCGAATCTGCGGCGTC
TGCAACCGGTAAAGCGCACGTCATCAAATCTCACCACAATGTCGGCGGCCTGCCGAAAGAGATGAAGATGGGGCTGGTTG
AACCGCTGAAAGAGCTGTTCAAAGACGAAGTGCGTAAGATTGGTCTGGAGCTGGGCCTGCCGTACGACATGCTGTATCGC
CATCCGTTCCCGGGGCCGGGCCTCGGCGTGCGCGTACTGGGCGAAGTGAAGAAAGAGTACTGCGACCTGCTGCGTCGCGC
GGACGCTATCTTCATTGAAGAGCTGCGCAAAGCGGATCTGTACGACAAAGTCAGTCAGGCGTTTACCGTCTTCCTGCCGG
TTCGTTCCGTTGGCGTTATGGGCGATGGTCGTAAGTATGACTGGGTTGTCTCTCTGCGTGCCGTCGAAACCATCGACTTT
ATGACCGCACACTGGGCGCACCTGCCGTATGACTTCCTCGGTCGCGTTTCCAACCGCATCATCAATGAAGTCAACGGGAT
TTCCCGTGTGGTGTATGACATCAGCGGTAAACCACCAGCTACCATTGAGTGGGAATAA

Protein sequence :
MTENIHKHRILILDFGSQYTQLVARRVRELGVYCELWAWDVTEAQIRDFNPSGIILSGGPESTTEENSPRAPQYVFEAGV
PVFGVCYGMQTMAMQLGGHVEGSNEREFGYAQVEVLTDSALVRGIEDSLTADGKPLLDVWMSHGDKVTAIPSDFVTVAST
ESCPFAIMANEEKRFYGVQFHPEVTHTRQGMRMLERFVRDICQCEALWTPAKIIDDAVARIREQVGDDKVILGLSGGVDS
SVTAMLLHRAIGKNLTCVFVDNGLLRLNEAEQVMDMFGDHFGLNIVHVPAEDRFLSALAGENDPEAKRKIIGRVFVEVFD
EEALKLEDVKWLAQGTIYPDVIESAASATGKAHVIKSHHNVGGLPKEMKMGLVEPLKELFKDEVRKIGLELGLPYDMLYR
HPFPGPGLGVRVLGEVKKEYCDLLRRADAIFIEELRKADLYDKVSQAFTVFLPVRSVGVMGDGRKYDWVVSLRAVETIDF
MTAHWAHLPYDFLGRVSNRIINEVNGISRVVYDISGKPPATIEWE

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
guaA YP_001331415.1 GMP synthase Not tested vSa¥á Protein 1e-127 51
SAMSHR1132_03620 YP_005324884.1 GMP synthase Not tested vSa¥á Protein 7e-128 51
SAPIG0468 YP_005733278.1 GMP synthase [glutamine-hydrolyzing] (Glutamineamidotransferase) (GMP synthetase) Not tested SAPI-S0385 Protein 6e-128 51
guaA NP_938969.1 GMP synthase Not tested Not named Protein 2e-110 48