Gene Information

Name : leuS (SPG_0241)
Accession : YP_002036956.1
Strain : Streptococcus pneumoniae G54
Genome accession: NC_011072
Putative virulence/resistance : Unknown
Product : leucyl-tRNA synthetase
Function : -
COG functional category : J : Translation, ribosomal structure and biogenesis
COG ID : COG0495
EC number : 6.1.1.4
Position : 224334 - 226835 bp
Length : 2502 bp
Strand : +
Note : leucine--tRNA ligase; LeuRS; class-I aminoacyl-tRNA synthetase; charges leucine by linking carboxyl group to alpha-phosphate of ATP and then transfers aminoacyl-adenylate to its tRNA; due to the large number of codons that tRNA(Leu) recognizes, the leucyl

DNA sequence :
ATGAGTTTTTACAATCATAAAGAAATTGAGCCTAAGTGGCAGGGCTACTGGGCAGAACATCATACATTTAAGACAGGAAC
AGATGCATCAAAACCTAAGTTTTATGCGCTTGATATGTTCCCTTATCCGTCTGGAGCTGGTCTGCACGTAGGACACCCAG
AAGGTTATACTGCAACCGATATCCTCAGTCGTTACAAACGTGCGCAAGGCTACAATGTCCTTCACCCAATGGGTTGGGAT
GCTTTTGGTTTGCCTGCAGAGCAATACGCTATGGATACTGGTAATGACCCAGCAGAATTTACAGCGGAAAACATTGCCAA
CTTCAAACGTCAGATCAATGCGCTTGGATTTTCTTATGACTGGGATCGTGAAGTCAACACAACAGATCCAAACTACTACA
AGTGGACTCAATGGATTTTCACCAAGCTTTACGAAAAAGGCTTGGCCTATGAAGCTGAAGTGCCAGTAAACTGGGTTGAG
GAATTGGGAACTGCCATTGCCAATGAAGAAGTGCTTCCTGACGGAACTTCTGAGCGTGGAGGCTATCCAGTTGTCCGCAA
ACCAATGCGCCAATGGATGCTCAAAATCACGGCTTACGCAGAGCGCTTACTCAATGACTTAGATGAACTTGATTGGCCAG
AGTCTATCAAGGACATGCAACGCAACTGGATTGGTAAATCAACTGGTGCTAATGTAACCTTTAAAGTTAAGGGAACGGAC
AAGGAATTCACAGTCTTTACCACTCGTCCTGATACTCTTTTCGGTGCGACTTTCACTGTCTTGGCTCCTGAACATGAATT
AGTAGACGCTATCACAAGTTCAGAGCAAGCAGAGGCTGTAGCAAACTATAAACATCAAGCTAGCCTCAAATCTGACTTGG
CTCGTACAGACCTTGCCAAAGAAAAAACTGGTGTTTGGACTGGTGCTTATGCCATCAACCCTGTCAATGGTAAGGAAATT
CCAATCTGGATTGCCGACTATGTTCTTGCTAGTTACGGAACAGGTGCCGTTATGGCCGTTCCAGCTCACGACCAACGTGA
CTGGGAATTTGCCAAACAATTTGACCTTCCAATCGTCGAAGTGCTTGAAGGTGGAAATGTAGCAGAAGCTGCCTATACAG
AGGATGGTCTTCATGTCAATTCAGACTTCCTAGATGGACTCAACAAAGAAGAAGCTATTGCCAAGATTGTGGCTTGGTTG
GAAGAAAAAGGCTGTGGACAAGAGAAGGTTACCTACCGTCTCCGCGACTGGCTCTTTAGCCGTCAACGTTACTGGGGTGA
ACCAATTCCTATCATTCATTGGGAAGATGGGACTTCAACAGCTGTTCCTGAAAGTGAATTGCCACTTGTCTTGCCTGTAA
CCAAGGATATCCGCCCTTCAGGTACAGGGGAAAGTCCATTGGCTAACTTGACAGATTGGCTTGAAGTGACTCGTGCAGAT
GGTGTCAAAGGTCGTCGTGAAACCAACACTATGCCACAATGGGCAGGTTCAAGCTGGTACTACCTCCGCTATATTGACCC
GCACAATACTGAGAAATTGGCTGATGAGGACCTCCTCAAACAATGGTTGCCAGTAGATATCTACGTGGGTGGTGCGGAAC
ATGCTGTACTTCACTTGCTTTATGCTCGTTTCTGGCATAAATTCCTCTATGACCTCGGTGTTGTTCCGACTAAGGAACCA
TTCCAAAAACTCTTTAACCAAGGGATGATTTTGGGAACAAGCTACCGTGACCACCGTGGTGCTCTTGTGACAACCGACAA
GGTTGAAAAACGTGATGGTTCCTTCTTCCATGTAGAAACAGGGGAAGAGTTGGAGCAAGCGCCAGCCAAGATGTCTAAAT
CGCTCAAGAACGTTGTTAACCCAGACGATGTGGTGGAACAATACGGTGCCGATACCCTTCGTGTTTATGAAATGTTTATG
GGACCACTCGATGCTTCGATTGCTTGGTCAGAAGAAGGTTTGGAAGGAAGCCGTAAGTTCCTTGACCGAGTTTACCGTTT
GATTACAAGTAAAGAAATCCTTGCGGAAAACAATGGTGCTCTTGACAAGGCTTACAACGAAACAGTCAAAGCTGTTACTG
AGCAAATTGAGTCTCTCAAATTCAACACAGCTATTGCCCAACTTATGGTCTTTGTCAATGCTGCTAACAAGGAAGATAAG
CTTTATGTTGACTATGCCAAAGGCTTTATTCAATTGATTGCACCATTTGCACCTCACTTGGCAGAAGAACTCTGGCAAAC
AGTCGCAGAAACAGGTGAGTCAATCTCTTATGTAGCTTGGCCAACTTGGGACGAAAGTAAACTGGTTGAAGACGAAATCG
AAATCGTTGTCCAAATCAAAGGTAAAGTCCGTGCCAAACTCATGGTCGCTAAAGACCTATCACGTGAAGAATTGCAAGAA
ATTGCTCTAGCGGATGAAAAAGTCAAAGCAGAAATTGACGGTAAGGAAATCGTGAAAGTGATTAGTGTACCAAATAAATT
GGTTAATATTGTTGTAAAATAA

Protein sequence :
MSFYNHKEIEPKWQGYWAEHHTFKTGTDASKPKFYALDMFPYPSGAGLHVGHPEGYTATDILSRYKRAQGYNVLHPMGWD
AFGLPAEQYAMDTGNDPAEFTAENIANFKRQINALGFSYDWDREVNTTDPNYYKWTQWIFTKLYEKGLAYEAEVPVNWVE
ELGTAIANEEVLPDGTSERGGYPVVRKPMRQWMLKITAYAERLLNDLDELDWPESIKDMQRNWIGKSTGANVTFKVKGTD
KEFTVFTTRPDTLFGATFTVLAPEHELVDAITSSEQAEAVANYKHQASLKSDLARTDLAKEKTGVWTGAYAINPVNGKEI
PIWIADYVLASYGTGAVMAVPAHDQRDWEFAKQFDLPIVEVLEGGNVAEAAYTEDGLHVNSDFLDGLNKEEAIAKIVAWL
EEKGCGQEKVTYRLRDWLFSRQRYWGEPIPIIHWEDGTSTAVPESELPLVLPVTKDIRPSGTGESPLANLTDWLEVTRAD
GVKGRRETNTMPQWAGSSWYYLRYIDPHNTEKLADEDLLKQWLPVDIYVGGAEHAVLHLLYARFWHKFLYDLGVVPTKEP
FQKLFNQGMILGTSYRDHRGALVTTDKVEKRDGSFFHVETGEELEQAPAKMSKSLKNVVNPDDVVEQYGADTLRVYEMFM
GPLDASIAWSEEGLEGSRKFLDRVYRLITSKEILAENNGALDKAYNETVKAVTEQIESLKFNTAIAQLMVFVNAANKEDK
LYVDYAKGFIQLIAPFAPHLAEELWQTVAETGESISYVAWPTWDESKLVEDEIEIVVQIKGKVRAKLMVAKDLSREELQE
IALADEKVKAEIDGKEIVKVISVPNKLVNIVVK

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
leuS YP_281511.2 leucyl-tRNA synthetase Not tested Not named Protein 0.0 90