Gene Information

Name : SPG_1231 (SPG_1231)
Accession : YP_002037939.1
Strain : Streptococcus pneumoniae G54
Genome accession: NC_011072
Putative virulence/resistance : Resistance
Product : tetracycline resistance protein TetM
Function : -
COG functional category : J : Translation, ribosomal structure and biogenesis
COG ID : COG0480
EC number : -
Position : 1192417 - 1194336 bp
Length : 1920 bp
Strand : -
Note : identified by match to protein family HMM PF00009; match to protein family HMM PF00679; match to protein family HMM PF03144; match to protein family HMM PF03764; match to protein family HMM TIGR00231

DNA sequence :
ATGAAAATTATTAATATTGGAGTTTTAGCTCATGTTGATGCAGGAAAAACTACCTTAACAGAAAGCTTATTATATAACAG
TGGAGCGATTACAGAATTAGGAAGCGTGGACAAAGGTACAACGAGGACGGATAATACGCTTTTAGAACGTCAGAGAGGAA
TTACAATTCAGACAGGAATAACCTCTTTTCAGTGGGAAAATACGAAGGTGAACATCATAGACACGCCAGGACATATGGAT
TTCTTAGCAGAAGTATATCGTTCATTATCAGTTTTAGATGGGGCAATTCTACTGATTTCTGCAAAAGATGGCGTACAAGC
ACAAACTCGTATATTATTTCATGCACTTAGGAAAATGGGGATTCCCACAATCTTTTTTATCAATAAGATTGACCAAAATG
GAATTGATTTATCAACGGTTTATCAGGATATTAAAGAGAAACTTTCTGCCGAAATTGTAATCAAACAGAAGGTAGAACTG
TATCCTAATATGTGTGTGACGAACTTTACCGAATCTGAACAATGGGATACGGTAATAGAGGGAAACGATGACCTTTTAGA
GAAATATATGTCCGGTAAATCATTAGAAGCATTGGAACTCGAACAAGAGGAAAGCATAAGATTTCAGAATTGTTCTCTGT
TCCCTGTTTATCACGGAAGTGCAAAAAACAATATAGGGATTGATAACCTTATAGAAGTGATTACGAATAAATTTTATTCA
TCAACACATCGAGGTCAGTCTGAACTTTGCGGAAAAGTTTTCAAAATTGAGTATTCGGAAAAAAGACAGCGTCTTGCATA
TATACGTCTTTATAGTGGCGTACTGCATTTGCGAGATTCGGTTAGAATATCGGAAAAGGAAAAAATAAAAATTACAGAAA
TGTATACTTCAATAAATGGTGAATTATGTAAAATTGATAAGGCTTATTCCGGGGAAATTGTTATTTTGCAGAATGAGTTT
TTGAAGTTAAATAGTGTTCTTGGAGATACAAAGCTATTGCCACAGAGAGAGAGAATTGAAAATCCCCTCCCTCTGCTGCA
AACGACTGTTGAACCGAGCAAACCTCAACAAAGGGAAATGTTACTTGATGCACTTTTAGAAATCTCCGACAGTGACCCGC
TTCTGCGATATTATGTGGATTCTGCGACACATGAAATCATACTTTCTTTCTTAGGGAAAGTACAAATGGAAGTGACTTGT
GCTCTGCTGCAAGAAAAGTATCATGTGGAGATAGAAATAAAAGAGCCTACAGTCATTTATATGGAAAGACCGTTAAAAAA
AGCAGAGTATACCATTCACATCGAAGTTCCACCGAATCCTTTCTGGGCTTCCATTGGTCTATCTGTAGCACAGCTTCCAT
TAGGGAGCGGAGTACAGTATGAGAGCTCGGTTTCTCTTGGATACTTAAATCAATCGTTTCAAAATGCAGTTATGGAGGGG
ATACGCTATGGCTGTGAACAAGGATTGTATGGTTGGAATGTGACGGACTGTAAAATCTGTTTTAAGTATGGCTTATACTA
TAGCCCTGTTAGTACCCCAGCAGATTTTCGGATGCTTGCTCCTATTGTATTGGAACAAGTCTTAAAAAAAGCTGGAACAG
AATTGTTAGAGCCATATCTTAGTTTTAAAATTTATGCGCCACAGGAATATCTTTCACGAGCATACAACGATGCTCCTAAA
TATTGTGCGAACATCGTAGACACTCAATTGAAAAATAATGAGGTCATTCTTAGTGGAGAAATCCCTGCTCGGTGTATTCA
AGAATATCGTAGTGATTTAACTTTCTTTACAAATGGACGTAGTGTTTGTTTAACAGAGTTAAAAGGGTACCATGTTACTA
CCGGTGAACCTGTTTGCCAGCCCCGTCGTCCAAATAGTCGGATAGATAAAGTACGATATATGTTCAATAAAATAACTTAG

Protein sequence :
MKIINIGVLAHVDAGKTTLTESLLYNSGAITELGSVDKGTTRTDNTLLERQRGITIQTGITSFQWENTKVNIIDTPGHMD
FLAEVYRSLSVLDGAILLISAKDGVQAQTRILFHALRKMGIPTIFFINKIDQNGIDLSTVYQDIKEKLSAEIVIKQKVEL
YPNMCVTNFTESEQWDTVIEGNDDLLEKYMSGKSLEALELEQEESIRFQNCSLFPVYHGSAKNNIGIDNLIEVITNKFYS
STHRGQSELCGKVFKIEYSEKRQRLAYIRLYSGVLHLRDSVRISEKEKIKITEMYTSINGELCKIDKAYSGEIVILQNEF
LKLNSVLGDTKLLPQRERIENPLPLLQTTVEPSKPQQREMLLDALLEISDSDPLLRYYVDSATHEIILSFLGKVQMEVTC
ALLQEKYHVEIEIKEPTVIYMERPLKKAEYTIHIEVPPNPFWASIGLSVAQLPLGSGVQYESSVSLGYLNQSFQNAVMEG
IRYGCEQGLYGWNVTDCKICFKYGLYYSPVSTPADFRMLAPIVLEQVLKKAGTELLEPYLSFKIYAPQEYLSRAYNDAPK
YCANIVDTQLKNNEVILSGEIPARCIQEYRSDLTFFTNGRSVCLTELKGYHVTTGEPVCQPRRPNSRIDKVRYMFNKIT

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
SSU05_0922 YP_001198287.1 translation elongation factor (GTPases) Not tested 89K Protein 0.0 96
SSU98_0928 YP_001200485.1 translation elongation factor (GTPases) Not tested 89K Protein 0.0 96
tetO AFJ97266.1 truncated tetracycline resistant protein Not tested Not named Protein 2e-164 75
tet(W) YP_005160006.1 tetracycline resistance protein Not tested Not named Protein 0.0 69

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
SPG_1231 YP_002037939.1 tetracycline resistance protein TetM X04388.gene.p01 Protein 0.0 98
SPG_1231 YP_002037939.1 tetracycline resistance protein TetM M85225.gene.p01 Protein 0.0 97
SPG_1231 YP_002037939.1 tetracycline resistance protein TetM NC_009782.5559075.p0 Protein 0.0 95
SPG_1231 YP_002037939.1 tetracycline resistance protein TetM NC_002758.1120355.p0 Protein 0.0 95
SPG_1231 YP_002037939.1 tetracycline resistance protein TetM AM180355.1.gene636.p Protein 0.0 93
SPG_1231 YP_002037939.1 tetracycline resistance protein TetM L09756.gene.p01 Protein 0.0 79
SPG_1231 YP_002037939.1 tetracycline resistance protein TetM AJ295238.gene.p01 Protein 0.0 72
SPG_1231 YP_002037939.1 tetracycline resistance protein TetM AY485126.gene.p01 Protein 0.0 70
SPG_1231 YP_002037939.1 tetracycline resistance protein TetM DQ294299.gene.p01 Protein 0.0 69
SPG_1231 YP_002037939.1 tetracycline resistance protein TetM AJ222769.gene.p01 Protein 0.0 69
SPG_1231 YP_002037939.1 tetracycline resistance protein TetM FN594949.1.gene24.p0 Protein 0.0 67
SPG_1231 YP_002037939.1 tetracycline resistance protein TetM L42544.gene.p01 Protein 4e-126 44
SPG_1231 YP_002037939.1 tetracycline resistance protein TetM AJ514254.gene.p01 Protein 3e-121 43
SPG_1231 YP_002037939.1 tetracycline resistance protein TetM Z21523.gene.p01 Protein 1e-108 41