Gene Information

Name : ureC (BCAL3106)
Accession : YP_002232217.1
Strain :
Genome accession: NC_011000
Putative virulence/resistance : Virulence
Product : urease subunit alpha
Function : -
COG functional category : E : Amino acid transport and metabolism
COG ID : COG0804
EC number : 3.5.1.5
Position : 3394760 - 3396466 bp
Length : 1707 bp
Strand : +
Note : ureases catalyze the hydrolysis of urea into ammonia and carbon dioxide; in Helicobacter pylori the ammonia released plays a key role in bacterial survival by neutralizing acids when colonizing the gastric mucosa; the holoenzyme is composed of 3 ureC (alp

DNA sequence :
ATGACACTACGCTTGAGCCGCCGCGCGTACGCGGAAATGTTCGGGCCGACGACGGGCGACCGCGTCCGGCTCGCCGATAC
CGAACTGCTGATCGAGATCGAACGCGACTTCACCACGTACGGCGAGGAAGTGAAATTCGGCGGCGGAAAAGTGATCCGCG
ACGGGATGGGCCAGTCGCAGCGCGTGGCCGCCGACGTGCCCGACACCGTCATCACGAACGCGGTGATCCTCGATCACTGG
GGCATCGTGAAGGCCGACATCGCGATCAAGCACGGCCGCATCGCCGCGATCGGCAAGGCCGGCAACCCCGACATCCAGCC
GGGCGTGACGATCGCGATCGGCGCCGCGACCGAAGTCATCGCCGGCGAAGGGCTGATCGTGACCGCGGGCGGCATCGACA
CGCACATTCACTTCATCAGCCCGCAGCAGATCGACGAGGCGCTCGCGTCGGGCGTCACGACGATGCTCGGCGGCGGCACG
GGGCCGGCCACCGGCACCAACGCGACGACCTGCACGCCGGGCCCGTGGCACATGGAGCGGATGCTGCAGGCCGCCGACGG
CTGGCCGATCAATCTCGGCTTTCTCGGCAAGGGCAACGCGAGCCTGCCGCAGCCGCTCGTCGAGCAGATCGCGGCCGGCG
CGATCGGTTTGAAACTGCACGAGGACTGGGGCACGACGCCCGCCGCGATCGACAACTGCCTGTCGGTGGCCGACGACACC
GACACGCAGGTCGCGATCCACACCGACACGCTGAACGAGGCCGGGTTCGTCGAATCGACGGTCGCCGCGTTCAAGGGCCG
CACGATCCACACGTACCACACCGAAGGTGCGGGCGGCGGCCATGCGCCCGACATCCTGAAGGTGTGCGGCGAGATGAACG
TGCTGCCGTCGTCGACCAATCCGACGCGCCCGTACACGATCAACACGCTCGACGAGCATCTCGACATGCTGATGGTGTGC
CATCACCTCGATCCGTCGATCGCCGAGGATCTCGCATTCGCCGAATCGCGCATTCGTCGCGAGACGATCGCGGCCGAGGA
CATCCTGCACGATCTCGGCGCGCTGTCGATGCTGTCGTCCGATTCGCAGGCGATGGGCCGCGTCGGCGAAGTGATCATCC
GCACCTGGCAGACCGCGCACAAGATGAAGGTGCAGCGCGGTGCGCTGCCGGAGGACACCGCGCGCAACGACAACTTCCGC
GCGAAGCGCTACGTCGCGAAGTACACGATCAACCCGGCGCTCACGCACGGCATCGCGCACGAAGTCGGTTCGATCGAACC
GGGCAAATGGGCAGACCTCGTGCTGTGGGAACCCGCGTTCTTCGGGATCAAGCCGTCGATGATCCTCAAGGGCGGCATGA
TCGCGCTCGCGCAGATGGGCGACCCGAACGCGTCGATCCCGACGCCGCAGCCGGTTCACTATCGCGAGATGTTCGCGACG
CGCGGCGGGGCGCTCGCGCGCACGTCGCTGACCTTCGTGTCGCAGATGGCGGCCGATGCGGGCATCGCGGAGCGCTATGG
CCTCGCGAAGCGGATCGTGCCGGTGCGCAACTGCCGCAACGTGACGAAGGCCGACATGATTCACAACGCCTGGCGTCCGT
CGATCAGCGTCGACCCGGAAACCTACGACGTGATCGCCGACGGCCAGTTGCTCACCTGCGAGCCGGCGACTGTGCTGCCG
ATGGCGCAGCGCTATTTCCTGTTCTGA

Protein sequence :
MTLRLSRRAYAEMFGPTTGDRVRLADTELLIEIERDFTTYGEEVKFGGGKVIRDGMGQSQRVAADVPDTVITNAVILDHW
GIVKADIAIKHGRIAAIGKAGNPDIQPGVTIAIGAATEVIAGEGLIVTAGGIDTHIHFISPQQIDEALASGVTTMLGGGT
GPATGTNATTCTPGPWHMERMLQAADGWPINLGFLGKGNASLPQPLVEQIAAGAIGLKLHEDWGTTPAAIDNCLSVADDT
DTQVAIHTDTLNEAGFVESTVAAFKGRTIHTYHTEGAGGGHAPDILKVCGEMNVLPSSTNPTRPYTINTLDEHLDMLMVC
HHLDPSIAEDLAFAESRIRRETIAAEDILHDLGALSMLSSDSQAMGRVGEVIIRTWQTAHKMKVQRGALPEDTARNDNFR
AKRYVAKYTINPALTHGIAHEVGSIEPGKWADLVLWEPAFFGIKPSMILKGGMIALAQMGDPNASIPTPQPVHYREMFAT
RGGALARTSLTFVSQMAADAGIAERYGLAKRIVPVRNCRNVTKADMIHNAWRPSISVDPETYDVIADGQLLTCEPATVLP
MAQRYFLF

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
ureC NP_286680.1 urease subunit alpha Virulence TAI Protein 0.0 71
ureC NP_287088.1 urease subunit alpha Not tested TAI Protein 0.0 71
ureC YP_005684266.1 Urease alpha subunit Not tested PiCp 7 Protein 7e-171 64
ureC YP_005682174.1 Urease alpha subunit Not tested PiCp 7 Protein 1e-171 64
ureC YP_003784325.1 urease subunit alpha Not tested PiCp 7 Protein 1e-171 64
ureC YP_005686358.1 Urease alpha subunit Not tested PiCp 7 Protein 1e-171 64

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
ureC YP_002232217.1 urease subunit alpha VFG0270 Protein 3e-160 65