Gene Information

Name : thyA (LCABL_16070)
Accession : YP_001987546.1
Strain : Lactobacillus casei BL23
Genome accession: NC_010999
Putative virulence/resistance : Unknown
Product : thymidylate synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0207
EC number : 2.1.1.45
Position : 1542588 - 1543538 bp
Length : 951 bp
Strand : +
Note : ThyA; catalyzes formation of dTMP and 7,8-dihydrofolate from 5,10-methylenetetrahydrofolate and dUMP; involved in deoxyribonucleotide biosynthesis; there are 2 copies in some Bacilli, one of which appears to be phage-derived

DNA sequence :
ATGTTAGAGCAGCCATATCTCGATCTTGCCCAAAAAGTATTAGATGAAGGCCATTTCAAGCCTGATCGCACGCATACAGG
CACGTACAGTATTTTTGGTCACCAAATGCGGTTTGACCTTAGCAAAGGGTTTCCTTTACTAACAACCAAAAAGGTGCGCT
TTGGTCTCATTAAAAGCGAGTTACTTTGGTTCTTGCGTGGCGATACCAACATTCGTTTCCTATTGCAGCACAAAAATCAC
ATCTGGGATGAATGGGCCTTTGAGAAGTGGGTTGCCAGCCCCGATTATCATGGTCCGGATATGACCGATTTTGGTCATCG
CAGCCAGAAAGATCCTGAATTTGCCGCCAGTTATCGTGAACAGATGGCCAAGTTTGACGAACGTATTCTCACTGACGAGT
CATTTGCAGCTAAATACGGTGATTTAGGATTGGTTTATGGCTCGCAATGGCGGGCGTGGCATACCAGTCGTGGTGACACC
ATCGACCAGCTGGGGGATGTGATTGAGCAGATTAAGACGCACCCATACTCGCGACGCTTGATCGTATCCGCTTGGAATCC
AGAAGATGTGCCAACCATGGCGTTACCGCCTTGTCACACCCTCTTCCAGTTTTATGTCAATGATGGCAAACTTTCCTTGC
AGCTGTATCAGCGCTCTGCGGACATTTTCCTTGGCGTGCCGTTTAATATTGCCTCATATGCCTTGCTGACCCATCTTGTT
GCCCATGAATGCGGGTTGCAAGTCGGGGACTTCATTCACACATTTGGAGATGCCCACTTGTATGTCAATCATTTGGACCA
AATCAAAGAACAATTAACGCGGACGCCTCGGCAGGCGCCAACCTTGGTCTTGAATCCGGATAAACACGATATTTTTGATT
TTGATATGCAAGATATTAAATTGTTGAATTATGATCCTTATCCGGCCATTAAGGCACCAGTTGCCGTTTAA

Protein sequence :
MLEQPYLDLAQKVLDEGHFKPDRTHTGTYSIFGHQMRFDLSKGFPLLTTKKVRFGLIKSELLWFLRGDTNIRFLLQHKNH
IWDEWAFEKWVASPDYHGPDMTDFGHRSQKDPEFAASYREQMAKFDERILTDESFAAKYGDLGLVYGSQWRAWHTSRGDT
IDQLGDVIEQIKTHPYSRRLIVSAWNPEDVPTMALPPCHTLFQFYVNDGKLSLQLYQRSADIFLGVPFNIASYALLTHLV
AHECGLQVGDFIHTFGDAHLYVNHLDQIKEQLTRTPRQAPTLVLNPDKHDIFDFDMQDIKLLNYDPYPAIKAPVAV

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
thyA YP_189147.1 thymidylate synthase Not tested ¥ÕSP¥â Protein 5e-105 66