Gene Information

Name : guaA (WPa_0492)
Accession : YP_001975270.1
Strain : Wolbachia endosymbiont wPip
Genome accession: NC_010981
Putative virulence/resistance : Unknown
Product : GMP synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0519
EC number : -
Position : 528270 - 529832 bp
Length : 1563 bp
Strand : +
Note : contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway

DNA sequence :
TTGTCAGCAATTGCCGTTATTGATTTTGGTTCACAGTTTACACAGCTTATTGCAAGACAAATCAGGGAAATGGGCGTTTA
CTGTGAAATATTTCCAAGCAATATCGATTTCGAAACAGTATCAAAATTCAATGGATTTATTTTTTCTGGAGGACCGCAAT
CTGTAAATGACAATTGCTCTGAAGTAAGTGAAGTAGCACATAAAATTATAAAACTTAACGAAACAATAAACACTCCTATA
CTTGGAATATGTTATGGACAGCAACTCATTTGTCATTATTTCGGGGCAAAGGTAAGAAAAGAATTCAATCAGGAATTTGG
CAAAACTAAAATCAAGATACTAAAAGAATCCCCAATTATAAAGGATACTTGGGACGTTAATTCCGAAGTCGATGTGCTAA
TGAACCATGCAGACAGTGTCGAAACTATACCGCAAGGATTTACTGCTATTGCCTCAGGTATAATAAATCAAACAATCGCA
ATAATTGCCAACGAACAGCGGAAGATTTACTGCACTCAGTTCCATCCTGAAGTTAAGCCTACGACAAATGGTAGTAAACT
TCTCTCTAATTTCTTAGATATTGCAAATTGTGAGAGAGATTGGACAATGAAGTCATTCATTGAAAAACAGAAGGAAAAAA
TTCAAAACTTAGTAGGGGAGAAAAAAGTAATTGCTGCAGTAAGTGGGGGGGTTGATTCAAGTGTTGCAGCAGTTCTTACA
CACAAAGCTATAGGAAAACAATTAAACTGTATTTTTATCGATACTGGGTTATTGCGTAAGAGCCAGACCACTGCTATGTT
AAAAGAAATTCCAATAAATTACGTTGATAAATCAAACTTGTTTTTAAGTAGGTTAAAGGGAATAACTGATCCGGAAGAAA
AGCGAAAAATTATCGGCAATACTTTTATCGAAGTATTTGAAGAAGAGGCAAAAAAAATAGGTGATGTGGATTTTTTAATG
CAAGGCACCATTTACTCTGATGTAGTTGAATCAGGGCACGCTTCAGGAAACACTAGTACAATTAAATCTCATCACAATGT
TGGTGGGTTGCCAGAAAAAATGAATCTGAAATTAGTAGAACCTTTACGCTATCTCTTTAAAGATGAAGTAAGGCTGCTTG
GCAAAGAAATTGGGCTTTCAGATGAGATAATATTTCAACATCCATTTCCTGGGCCTGGACTTGCAGTGAGGATCATATGT
GAGGTTGATGAAGAAAAGGTACGAATATTGCAAGAAGTAGATGAAATATATATCAACACAATGAAAAATTATGATCTGTA
TGATAAAATATGGCAGGCTTTTGCTGTACTGTTACCAGTAAAAACTGTGGGAGTTATGGGAGATAATCGTACATACGGAT
ATGTTTGCGCTTTAAGGGCTGTGACTTCATCTGATGGCATGACAGCTGATGCATTTCCATTTGAAAATAAAGATCAACAT
TCGTTAGTATTTTGGAGGTTTTTGCAAGACATCAGTAGTATAATTGTTAACAAAGTTTCCAGAGTAAATCGAGTTGTGTA
TGATTTAACTTCCAAGCCACCAGCAACTATTGAGTGGGAGTAG

Protein sequence :
MSAIAVIDFGSQFTQLIARQIREMGVYCEIFPSNIDFETVSKFNGFIFSGGPQSVNDNCSEVSEVAHKIIKLNETINTPI
LGICYGQQLICHYFGAKVRKEFNQEFGKTKIKILKESPIIKDTWDVNSEVDVLMNHADSVETIPQGFTAIASGIINQTIA
IIANEQRKIYCTQFHPEVKPTTNGSKLLSNFLDIANCERDWTMKSFIEKQKEKIQNLVGEKKVIAAVSGGVDSSVAAVLT
HKAIGKQLNCIFIDTGLLRKSQTTAMLKEIPINYVDKSNLFLSRLKGITDPEEKRKIIGNTFIEVFEEEAKKIGDVDFLM
QGTIYSDVVESGHASGNTSTIKSHHNVGGLPEKMNLKLVEPLRYLFKDEVRLLGKEIGLSDEIIFQHPFPGPGLAVRIIC
EVDEEKVRILQEVDEIYINTMKNYDLYDKIWQAFAVLLPVKTVGVMGDNRTYGYVCALRAVTSSDGMTADAFPFENKDQH
SLVFWRFLQDISSIIVNKVSRVNRVVYDLTSKPPATIEWE

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
guaA YP_001331415.1 GMP synthase Not tested vSa¥á Protein 4e-106 48
SAPIG0468 YP_005733278.1 GMP synthase [glutamine-hydrolyzing] (Glutamineamidotransferase) (GMP synthetase) Not tested SAPI-S0385 Protein 3e-106 48
SAMSHR1132_03620 YP_005324884.1 GMP synthase Not tested vSa¥á Protein 3e-106 48
guaA NP_938969.1 GMP synthase Not tested Not named Protein 3e-86 42