Gene Information

Name : guaA (PGN_0635)
Accession : YP_001928751.1
Strain : Porphyromonas gingivalis ATCC 33277
Genome accession: NC_010729
Putative virulence/resistance : Unknown
Product : GMP synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0519
EC number : -
Position : 694658 - 696178 bp
Length : 1521 bp
Strand : -
Note : contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway

DNA sequence :
ATGTTGGAAAAGCTCATTATTCTGGATTTCGGTTCTCAAACCACACAGCTCATCGCCAGACGAATTCGCGAGCTGAACAC
CTACTGCGAGGTTTATCCCTACAACAAACTGCCGGAAGACCTCTCAGGAGTGCGAGGCATCATCCTGTCGGGGAGTCCTT
ATTCCGTGTATGACAGCAAAGCCTTTCGTATCGAACTGAGCGAATTACGGGGCAAGTTGCCTCTCTTGGGCATCTGCTAC
GGTGCACAGAGCCTTGTCCATCAAGCCGGTGGCAAAGTAGAGCCGTGCGACAGTCGCGAATACGGGCGAACACATCTGAC
CCTCCGGCAGCCTGAAGATGCACTGCTGACAGGCTTGCAATCCGGCACTACGGTGTGGATGTCCCACGGCGATACCATTA
CGTCATTGCCTGAAGGATTCGAGGTCATAGCAGGTACCGAGGATGTACCCAATGCAGCATTTCGCATCCGAGGAGAGAAA
ACGTGGGGCGTACAGTTCCATCCCGAGATCTACCACTCGGAAGAAGGTACCAAACTGCTTGGCAACTTCCTCGATATATG
CGGTATGAAGCGTGATTGGACTCCGGCTTCTTTCATCGAAGCGACTGTGCAGGAACTTCGCGAACGCTTAGGTGATGACA
AGGTGATCCTGGCACTCTCCGGAGGTGTGGACAGTTCGGTGGTGGCGGTGCTTCTGAACAAAGCTATCGGCCGCAACCTG
ACTTGTATATTCGTCGATCACGGCTTGCTGCGTAAGGGCGAATTCGAACGCGTACTTCAGGATTACGAGCACTTGGGTCT
CAATGTAATCGGGGTGAATGCAAAAGAAAAATTCTTCGCAGCCCTTAGCGGCGTTACCGATCCCGAGCAAAAACGGAAGA
TTATCGGTCGCGGCTTCATCGAAGTGTTCGACGAAGAAGCCCGGAAGCTGAAAGATATCAAATGGCTTGGTCAGGGCACG
ATCTACCCCGATGTCATTGAAAGTCTGAGTATCACCGGTATGGTGATCAAGAGTCACCACAATGTGGGAGGACTGCCCGA
GCGGATGAATCTCCGCCTCGTGGAACCGCTCCGTATGCTCTTCAAGGACGAAGTCCGTCGCGTGGGACTCGAGCTCGGCA
TGATGCCACACCTGATCCATCGCCATCCTTTCCCCGGTCCCGGTCTCGGCATCCGTATTCTCGGAGAGATCACGGAAGAG
AAAGCTACCATCTTGCAGAACGCCGATGACATCTATATGAGCCTTATGCGCGAGTGGGGGCTGTATGATCAGGTGTGGCA
GGCCGGAGCCATCCTGCTGCCGGTTCGGTCCGTAGGCGTAATGGGCGACGAGCGTACCTACGAATACACCGTGGCACTGC
GTGCCGTGACTTCTATGGATGCCATGAGTGCCGATTGGGTGCATTTGCCGTATGATTTTCTGGCCAAGGTGTCGAACGAA
ATAATCAATAAAGTGCGTGGCGTAAACCGCGTAGTCTACGACATCTCCTCCAAACCCCCCAGCACGATCGAATGGGAATA
A

Protein sequence :
MLEKLIILDFGSQTTQLIARRIRELNTYCEVYPYNKLPEDLSGVRGIILSGSPYSVYDSKAFRIELSELRGKLPLLGICY
GAQSLVHQAGGKVEPCDSREYGRTHLTLRQPEDALLTGLQSGTTVWMSHGDTITSLPEGFEVIAGTEDVPNAAFRIRGEK
TWGVQFHPEIYHSEEGTKLLGNFLDICGMKRDWTPASFIEATVQELRERLGDDKVILALSGGVDSSVVAVLLNKAIGRNL
TCIFVDHGLLRKGEFERVLQDYEHLGLNVIGVNAKEKFFAALSGVTDPEQKRKIIGRGFIEVFDEEARKLKDIKWLGQGT
IYPDVIESLSITGMVIKSHHNVGGLPERMNLRLVEPLRMLFKDEVRRVGLELGMMPHLIHRHPFPGPGLGIRILGEITEE
KATILQNADDIYMSLMREWGLYDQVWQAGAILLPVRSVGVMGDERTYEYTVALRAVTSMDAMSADWVHLPYDFLAKVSNE
IINKVRGVNRVVYDISSKPPSTIEWE

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
SAPIG0468 YP_005733278.1 GMP synthase [glutamine-hydrolyzing] (Glutamineamidotransferase) (GMP synthetase) Not tested SAPI-S0385 Protein 3e-125 54
SAMSHR1132_03620 YP_005324884.1 GMP synthase Not tested vSa¥á Protein 2e-125 54
guaA YP_001331415.1 GMP synthase Not tested vSa¥á Protein 4e-125 53
guaA NP_938969.1 GMP synthase Not tested Not named Protein 3e-112 48