Gene Information

Name : thyA (PGN_2062)
Accession : YP_001930177.1
Strain : Porphyromonas gingivalis ATCC 33277
Genome accession: NC_010729
Putative virulence/resistance : Unknown
Product : thymidylate synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0207
EC number : -
Position : 2313369 - 2314172 bp
Length : 804 bp
Strand : -
Note : ThyA; catalyzes formation of dTMP and 7,8-dihydrofolate from 5,10-methylenetetrahydrofolate and dUMP; involved in deoxyribonucleotide biosynthesis; there are 2 copies in some Bacilli, one of which appears to be phage-derived

DNA sequence :
TTGCGTGGTATGAAACAGTATTTGGATCTGCTTCGCCGCATCCTCGACGAGGGAGTACGAAAAGAAGACCGCACGGGTAC
GGGTACGATCAGCGTATTCGGCCATCAGATGTGCTTTGACCTTGAAGAGGGATTTCCCTTGCTTACGACCAAGCGATTGC
ACTTGAAGTCCATTATATACGAACTGCTTTGGTTCCTCAGAGGTGATACGAACGTGCATTACCTGCAGGAACATGGCGTA
CGCATTTGGAACGAATGGGCTGATGAGAACGGCGATTTGGGGCCTATATATGGCTACCAGTGGCGCAGTTGGCCGGACTA
TCGGGGAGGGCATATAGACCAAATGCAGGAGGTGCTGCGCCAGCTGCGCGAGGAACCGGACAGCCGGCGCATTATCGTAT
GCTCGTGGAATGTAGGCCAGCTTGCCGATATGCATCTGCCTCCATGCCACTGTTTCATGCAGTTCTATGTCGCTGACGGC
CGGCTGAGCCTGCAACTCTATCAGCGCAGTGCCGATTCTTTTCTGGGCATACCGTTCAACATAGCTTCGTATGCACTCCT
GCTACAAATGATCGCTCATGTCACAGGGCTGAAACCCGGGCGATTCGTACATACACTGGGCGACGCCCATATCTATCTTA
ACCACCTCGAACAGGTACAGCTACAACTGAGTCGTGAGCCGAGAGCGTTGCCCCGAATGGTACTGAATCCGGAGGTGTCC
GATCTCTTCGACTTCCGATACGAAGACTTCCGACTCGAAGGGTATGATCCGCATCCGCACATTGCGGGCGTTGTAGCAGT
CTGA

Protein sequence :
MRGMKQYLDLLRRILDEGVRKEDRTGTGTISVFGHQMCFDLEEGFPLLTTKRLHLKSIIYELLWFLRGDTNVHYLQEHGV
RIWNEWADENGDLGPIYGYQWRSWPDYRGGHIDQMQEVLRQLREEPDSRRIIVCSWNVGQLADMHLPPCHCFMQFYVADG
RLSLQLYQRSADSFLGIPFNIASYALLLQMIAHVTGLKPGRFVHTLGDAHIYLNHLEQVQLQLSREPRALPRMVLNPEVS
DLFDFRYEDFRLEGYDPHPHIAGVVAV

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
thyA YP_001800914.1 thymidylate synthase Not tested Not named Protein 5e-77 62