Gene Information

Name : lysS (PGN_1157)
Accession : YP_001929273.1
Strain : Porphyromonas gingivalis ATCC 33277
Genome accession: NC_010729
Putative virulence/resistance : Virulence
Product : lysyl-tRNA synthetase
Function : -
COG functional category : J : Translation, ribosomal structure and biogenesis
COG ID : COG1190
EC number : -
Position : 1286119 - 1287855 bp
Length : 1737 bp
Strand : -
Note : class II; LysRS2; catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; in Methanosarcina barkeri, LysRS2 charges both tRNA

DNA sequence :
ATGAACATACTCGAACTTTCGGAACAAGAAGTCGTACGCCGTAACAGCTTAGAGCAACTGCGTAATTTGGGGATCGATCC
ATATCCTGCAGCGGAATATACCGTCAATGCCTATTCCACCGAGATCAAAAGGAATTTCAATGGCGATGAGAATGCCGCCA
AACGTCAAGTAAGCATTGCCGGACGTATTATGAGCCGCCGTATCATGGGGAAAGCTACATTCATGGAGCTGCAAGATGCT
GAGGGGCGTATCCAGATCTATATTACTCGGGACGATATTTGTCCGGGTGAGGATAAGGAGTTCTACAATACGGTGGTCAA
GAAGTGTACGGATATAGGTGATTTCATCGGAGTGAAAGGGTACGTATTCCGCACTCAGATGGGAGAAATATCGGTGCATG
TGCAGGAGATGACTTTCTTGTCGAAAGCTATCCGCCCCCTTCCTGTGGTAAAAGAAAAAGATGGGGAGGTCTTCGATGGC
TTCACGGATTCGGAGCAGCGTTATCGTCAGCGATACGTGGATCTGGTCGTCAATAGTCATGTCAAAGACATTTTCCTCAA
GCGTACGATGGTATTCAATTCGATGCGCAGTTTCTTCAATGAGCGCGGATACATCGAAGTGGATACACCTGTACTCCAAT
CGATCCCGGGAGGTGCAGCTGCGCGTCCTTTTATCACGCATCATAACGCTCTGGACATTCCGCTCTATCTGAGAATCGCT
AACGAATTGTATCTGAAGCGTCTGATCGTGGGCGGTTTCGATGGTGTGTATGAATTCAGCCGCAATTTCCGAAATGAGGG
GATGGACCGCACGCATAATCCTGAGTTCACGGCCATGGAGATCTATGTGGCCTATAAGGATTACAATTGGATGATGAACT
TTACGGAGCAGATGCTCGAACGCATCTGTATGGATGTGCTGGGTACTACTCAGGTGAAGGTGGGCGAGAAATTGATCGAC
TTCAAGGCCCCCTACAGGCGAGTGACCATGATCGAAGCCATCCATGAGCATACGGGTATCGACATCAGCGGAATGAACGA
GGCCGAGCTGCGTCAGGTATGCGACAAGCTGGGCGTAGAGCACAATGAAACGATGGGCAAAGGCAAGCTCATCGATGAGA
TCTTCGGCGAGAAGTGCGAGAAGAACTATATCCAGCCTACTTTCATCACAGACTATCCGAAAGAAATGTCGCCTCTGACG
AAAGAACACCGCACCAATCCGGAGCTGACAGAGCGATTCGAGCTGATGGTCAATGGCAAGGAGTTGGCCAACGCCTACTC
GGAGCTGAACGACCCGATTGACCAGAGAGAACGTTTCGAAGAACAACTCAAGCTGTCCGAGAAAGGCGATGACGAAGCCA
TGTACATCGACAACGACTTCATCCGTGCCCTTGAATACGGTATGCCGCCGACCAGCGGTATGGGTATCGGTATGGACCGT
TTGGTCATGCTATTGACAGGGCAGGAGAGTATTCAGGAGGTGCTCCTCTTCCCACAGATGAAGCCCGAGAAGGTGGCTCC
ACGAGATACGAAAGAGAAGTTCGCCGTTTGTGGCATTCCCGAAGAGTGGGTACCTGTACTGCATAAGGCCGGCTATCTTA
CCGTACAGTCGATGCGAGAGGATAAACCGGGCAAGGTGATGCAGCAGCTGATGGACATCAATAAGAAATATAAGTTGGGG
CTTGCCGGTTTGAATCTGGAAACCGTTTCGGCTTGGCAGGAAGCCCCATATGAGTAA

Protein sequence :
MNILELSEQEVVRRNSLEQLRNLGIDPYPAAEYTVNAYSTEIKRNFNGDENAAKRQVSIAGRIMSRRIMGKATFMELQDA
EGRIQIYITRDDICPGEDKEFYNTVVKKCTDIGDFIGVKGYVFRTQMGEISVHVQEMTFLSKAIRPLPVVKEKDGEVFDG
FTDSEQRYRQRYVDLVVNSHVKDIFLKRTMVFNSMRSFFNERGYIEVDTPVLQSIPGGAAARPFITHHNALDIPLYLRIA
NELYLKRLIVGGFDGVYEFSRNFRNEGMDRTHNPEFTAMEIYVAYKDYNWMMNFTEQMLERICMDVLGTTQVKVGEKLID
FKAPYRRVTMIEAIHEHTGIDISGMNEAELRQVCDKLGVEHNETMGKGKLIDEIFGEKCEKNYIQPTFITDYPKEMSPLT
KEHRTNPELTERFELMVNGKELANAYSELNDPIDQRERFEEQLKLSEKGDDEAMYIDNDFIRALEYGMPPTSGMGIGMDR
LVMLLTGQESIQEVLLFPQMKPEKVAPRDTKEKFAVCGIPEEWVPVLHKAGYLTVQSMREDKPGKVMQQLMDINKKYKLG
LAGLNLETVSAWQEAPYE

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
unnamed CAD66193.1 putative lysil-tRNA synthetase LysU Not tested PAI III 536 Protein 8e-107 46

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
lysS YP_001929273.1 lysyl-tRNA synthetase VFG1668 Protein 5e-107 46