Gene Information

Name : CLH_2538 (CLH_2538)
Accession : YP_001921918.1
Strain : Clostridium botulinum Alaska E43
Genome accession: NC_010723
Putative virulence/resistance : Virulence
Product : tetanolysin O
Function : -
COG functional category : -
COG ID : -
EC number : -
Position : 2689057 - 2690865 bp
Length : 1809 bp
Strand : +
Note : identified by match to protein family HMM PF01289

DNA sequence :
ATGAAAACTACTAAAAAACTTCTTAAGTCATTTGCACAAGGATTATTAGCAGTTATGCTTATCAATGGATTTGCATATAT
TAGTGATTTTAAAACTAATAACAATGTTTTTCTATCAGGCATAACAGAAGATAATTCTGCAAAAGAAACTACAGATAAAA
ATGTAATTACTGAAAATATTAGTGATGAAACAAAAAATGTTGTATCAGATAATAAAACAGATAATAGTTTATCTGAAAAA
AATGTATTAGATGAGGGCACACAAACAGATGGTGACTTACTAAATACAGATTCTGTACAAGCTATTAATCCCATTACTAT
TAATCCTATAGTTGATCCTATCAAATCTATTGAAGAACCAATTATAGAAGATATACCTCTTATAAGAGATACTTTAAAAA
ATGAAATTAATGATATTGATAAAAATATCTATGGATTATCATATAACCCTGATAAGATACTATCTTCAAAAGGTGAAAGC
GTTGATAGCTTTGTGCCTGCTCAAGGTTTTGATACTCCAAATAAATATATTGTAGTAAAAAGAGAAAAGAAAAGTATATC
TGACTCTACTGCAGATATTTCAATAATAGACTCAATTAATGATAGAACTTACCCTGGTGCTATTCAACTTGCAAATAGAA
ATCTTGTAGAAAACAAACCTGATATAATTTCTTGTAAAAGAAAACCAATAACTATAAGTGTTGACTTACCTGGAATGAGT
GAGGATGGTAGTAAAGTTGTTAATTCACCAACATATTCTACTGTAAATTCTTCAATAAATTCTCTACTAGATACTTGGAA
TACAAAATACGCATCTAAATATACTATTCCTACAAGAATGAGCTATACTGATGCTATGGTATATAGTAAATCTCAATTAT
CTACAATGTTTGGTTGCAATTTCAAAATTTTAGACAAAGCATTAAATATAGATTTCAATTCTATATTTAAAGGTGAAAAA
CAAGCTATGGTTGTTGCATATAAGCAAATATTCTATACAGTTAGTGTAGATGCGCCTGAAAAACCTTCTGACTTATTTGG
CGACAATGTAAGCTTTCATGAATTAGCTTTAAAAGGTGTAGATAACGAAAATCCACCTGCATATGTTTCAAATGTAGCCT
ATGGTAGAACAATTTATGTAAAACTTGAGACTACATCTAAGAGTGCAAATGTTAAAGCAGCATTTAAAGCTTTAGTTTCT
AACCAAGATATCAGTGGTAACACAGAATATGAAGATATCTTAGAGCAAAGCTCATTTACAGCTACAGTTCTTGGTGGTGG
TGCTGAAGCCCATAACAAAGTAGTTACTAAAGATTTTAATGAAATACAAAATATAATACAAAACAACTCAGTATATAGTC
CTAAAAATCCTGGATATCCTATTTCATACACAAGTACATTCTTAAAAGATAATAGAATTGCTACTGTAAATAATAAAACA
GAATATATTGAAACAACATCAACAGAATATACTAATGGTAAAATTATTCTTGATCATAGTGGTGCTTATGTTGCTCAATT
TGAAGTAACTTGGGACGAAGTTAGCTATGATAAAGATGGTAATGAAATAATAGAGCATAAGATTTGGTCTGGAAGTGATA
AAGATAAAACTGCTCACTTTAATACAGAAATATATCTAAAAGGAAATGCTAGAAATATTTCCGTTAAAGCATGGGAGTGT
ACAGGCCTTGCATGGGAATGGTGGAGACAAGTTATAGATGCTCAAAATATCCCATTAGTAAAAGAAAGAACATTCTCAAT
ATGGGGTACAACACTATATCCTAACAAATCTGTTGAACCAGAAATTTAA

Protein sequence :
MKTTKKLLKSFAQGLLAVMLINGFAYISDFKTNNNVFLSGITEDNSAKETTDKNVITENISDETKNVVSDNKTDNSLSEK
NVLDEGTQTDGDLLNTDSVQAINPITINPIVDPIKSIEEPIIEDIPLIRDTLKNEINDIDKNIYGLSYNPDKILSSKGES
VDSFVPAQGFDTPNKYIVVKREKKSISDSTADISIIDSINDRTYPGAIQLANRNLVENKPDIISCKRKPITISVDLPGMS
EDGSKVVNSPTYSTVNSSINSLLDTWNTKYASKYTIPTRMSYTDAMVYSKSQLSTMFGCNFKILDKALNIDFNSIFKGEK
QAMVVAYKQIFYTVSVDAPEKPSDLFGDNVSFHELALKGVDNENPPAYVSNVAYGRTIYVKLETTSKSANVKAAFKALVS
NQDISGNTEYEDILEQSSFTATVLGGGAEAHNKVVTKDFNEIQNIIQNNSVYSPKNPGYPISYTSTFLKDNRIATVNNKT
EYIETTSTEYTNGKIILDHSGAYVAQFEVTWDEVSYDKDGNEIIEHKIWSGSDKDKTAHFNTEIYLKGNARNISVKAWEC
TGLAWEWWRQVIDAQNIPLVKERTFSIWGTTLYPNKSVEPEI

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
slo YP_281505.1 streptolysin O Virulence Not named Protein 7e-119 55
hly AAA69525.1 listeriolysin O Virulence LIPI-1 Protein 5e-111 50

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
CLH_2538 YP_001921918.1 tetanolysin O VFG2275 Protein 5e-131 61
CLH_2538 YP_001921918.1 tetanolysin O VFG0976 Protein 2e-119 55
CLH_2538 YP_001921918.1 tetanolysin O VFG0074 Protein 2e-111 50
CLH_2538 YP_001921918.1 tetanolysin O VFG1363 Protein 2e-100 45