Gene Information

Name : CLH_2469 (CLH_2469)
Accession : YP_001921850.1
Strain : Clostridium botulinum Alaska E43
Genome accession: NC_010723
Putative virulence/resistance : Resistance
Product : chloramphenicol O-acetyltransferase
Function : -
COG functional category : V : Defense mechanisms
COG ID : COG4845
EC number : 2.3.1.28
Position : 2638461 - 2639084 bp
Length : 624 bp
Strand : -
Note : identified by match to protein family HMM PF00302

DNA sequence : 
ATGAATTTTACAATTATAAATAAAGAAACTTGGGATAGAAAAGAATATTTTGAACACTATTTTTCTGAAATTCCATGTAC
ATATAGTATAACTACTAAATTAGATATTACGAAAATCAAAAAAGAAAATCAGAATATATATCCAACAATGTTATATTTAA
TTTCAAAAGTGGTTAACAATCATAGTGAATTTAGAATTTCTTTTGATATGAATGGAGAATTAGGTGTTTTTGATAAAATG
CATCCATCCTATACAGTATTTCATAAAGATACGGAGACTTTTTCTAATATTTGGACAGAGTATTCTGATGAGTATGAAAC
TTTTTGCAAATTATATGAAAAAGACATATGTACATTTGGTTCAGTAAAAAAAATTAATGCAAAACCCAATATACCCGAAA
ATAGCTTTTCGGTATCAATGCTTCCATGGACAACATTTGATGGATTTAATTTAAATTTACAAAAAGGATATAATTATTTA
ATACCTATATTTACTATAGGAAAGTATTATGAAGAAAATGGGAGATATATGATTCCATTAGCAATACAGGTTCATCATGC
AGTATGTGATGGATTTCATGTATGCCGTTTTGTAAATGAATTACAAGGATTAATAGAAGATTAA

Protein sequence : 
MNFTIINKETWDRKEYFEHYFSEIPCTYSITTKLDITKIKKENQNIYPTMLYLISKVVNNHSEFRISFDMNGELGVFDKM
HPSYTVFHKDTETFSNIWTEYSDEYETFCKLYEKDICTFGSVKKINAKPNIPENSFSVSMLPWTTFDGFNLNLQKGYNYL
IPIFTIGKYYEENGRYMIPLAIQVHHAVCDGFHVCRFVNELQGLIED

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
cat CAJ77070.1 Chloramphenicol acetyltransferase Not tested AbaR1 Protein 2e-36 45
cat YP_006098370.1 chloramphenicol acetyltransferase Not tested Tn2411 Protein 2e-36 45
cat AAL08441.1 chloramphenicol acetyltransferase Not tested SRL Protein 1e-35 43
catA2 ACF06176.1 chloramphenicol acetyltransferase II Not tested Tn5036-like Protein 4e-35 42

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
CLH_2469 YP_001921850.1 chloramphenicol O-acetyltransferase CP001581.1.gene2168. Protein 4e-46 50
CLH_2469 YP_001921850.1 chloramphenicol O-acetyltransferase NC_010111.5787932.p0 Protein 8e-42 48
CLH_2469 YP_001921850.1 chloramphenicol O-acetyltransferase CP004022.1.gene799.p Protein 1e-35 46
CLH_2469 YP_001921850.1 chloramphenicol O-acetyltransferase NC_011586.7045194.p0 Protein 8e-37 45
CLH_2469 YP_001921850.1 chloramphenicol O-acetyltransferase NC_010558.1.6276004. Protein 8e-37 45
CLH_2469 YP_001921850.1 chloramphenicol O-acetyltransferase NC_010410.6002590.p0 Protein 8e-37 45
CLH_2469 YP_001921850.1 chloramphenicol O-acetyltransferase NC_010426.6155849.p0 Protein 3e-35 43
CLH_2469 YP_001921850.1 chloramphenicol O-acetyltransferase NC_010427.6155852.p0 Protein 3e-35 43

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
CLH_2469 YP_001921850.1 chloramphenicol O-acetyltransferase VFG1032 Protein 6e-36 43