Gene Information

Name : arsA (CLH_2411)
Accession : YP_001921792.1
Strain : Clostridium botulinum Alaska E43
Genome accession: NC_010723
Putative virulence/resistance : Resistance
Product : arsenical pump-driving ATPase ArsA
Function : -
COG functional category : P : Inorganic ion transport and metabolism
COG ID : COG0003
EC number : 3.6.3.16
Position : 2587557 - 2589305 bp
Length : 1749 bp
Strand : +
Note : identified by match to protein family HMM PF02374; match to protein family HMM TIGR00345

DNA sequence :
TTGTTTAAACTATTTGATTTAGAAAAGATAAATTTAACTAAATATTTATTTTTTACTGGTAAAGGGGGAGTTGGTAAGAC
TTCAACCGCTTGTGCAGTAGCAGTTACTTTAGCAGATTTAGGAAAGAAGATAATGCTTGTTAGTACAGATCCAGCTTCAA
ATCTTCAGGATGTATTTGATACAGAATTAAATAATAAAGGAGTAAAAATAAACGGTATTCCTAATTTAATGGTAGCAAAT
TTTAGTCCAGAGGATGCTGCAGCTGAGTATAGGGAAAGTGTTATATCTCCATATAGGGGAAAGTTGCCAGAAGCTGTTTT
GAATAATATGGAAGAACAACTTTCTGGTTCATGTACAGTTGAAATAGCAGCTTTTAATGAATTTTCGGCAATGATAACTG
ATAAAAATGTAAGTAATGAATATGATCATATTATTTTTGATACAGCTCCAACAGGACATACCTTAAGAATGCTTCAATTA
CCTTCAGCTTGGAGTAATTTTATTAATGAAAGTACTCATGGAGCATCATGTCTTGGTCAACTTGCAGGGTTAGAGGATAA
AAAAGACATGTATAAAAAGGCAGTTTATACCCTAGCAGATAAAGAAAAAACTACACTTATACTTGTTTCAAGGGCAGAAA
TAACTCCTTTAAAAGAAGCAGAAAGAGCATCTAAGGAACTTGAAGATATAGGAGTTAAAAATCAAATTTTAATTATAAAT
GGTGTACTTCAACAATGTGATGATTATTTATCTAAATCTATTTATGATAAACAACAAAATTCGCTAAAAGATATTCCAGA
AGGATTAAAGAATATTAAAACTTTTGAAATTCCATTAAGACCTTATAATATAACAGGATTAGAAAACGTAAGGTCATTAT
TAAAAGACAACTATACTGTAGTTGATAATGAAATTTTAAATATAACTGAAATACCAAAGCTAAATAGTATAATTGAAGAT
CTATATAAAAATGATAAAAAAGTAATATTTACAATGGGAAAGGGAGGCGTAGGAAAGACTACTATAGCTGCTGCAATTGC
ACTTGGGTTATCAAAAAAGGGCAAGAAAGTACATTTAACAACAACTGACCCTGCTGGACATTTGAAATTTGTATTAGATG
AAAGTTATGGAATTTCTTTAAGTAATATTGATGAAAAAGAAGAACTTGAAAAATATAAAGAAGAAGTGTTAAAAAAAGCA
AGAGAAAATAACATGAGCGACGAGGATATAGCTTATGTTGAAGAAGATTTAAGATCTCCATGTACTCAGGAAATAGCTGT
ATTTAGAGCTTTTGCTGAAATAGTTGAAAGGTCAGAAAATGAGGTTGTTGTTATTGATACAGCACCAACTGGGCATACTT
TATTACTTTTAGAATCAACTGAAAGTTATAATAGGGAAATTGTTAGATCAGAAGGAGATATCCCAGAATCAGTTATAAAG
CTTTTACCAAAATTAAAAAATCATAAAGATACTGAAGTTATAATTGTAACTTTAGCAGAAACAACACCAATTTATGAAGC
TATGAGGCTTCAAGAAGATTTAAATAGGGCAGAAATTTATAGTAACTGGTGGGTAATAAATTCAAGTCTTTATGCTACAA
ACACTAGCAATGAGATATTAAAAGCTAAAGCTAGCAATGAAATAAGGTGGATAAATAAAGTAGATAAAATATCAAATGGA
AATTTTGCAGTAATTAAGTGGAAACCCGAGGAAATAAAAGATGATAGGCTTAAAGAATTACTAGATTAG

Protein sequence :
MFKLFDLEKINLTKYLFFTGKGGVGKTSTACAVAVTLADLGKKIMLVSTDPASNLQDVFDTELNNKGVKINGIPNLMVAN
FSPEDAAAEYRESVISPYRGKLPEAVLNNMEEQLSGSCTVEIAAFNEFSAMITDKNVSNEYDHIIFDTAPTGHTLRMLQL
PSAWSNFINESTHGASCLGQLAGLEDKKDMYKKAVYTLADKEKTTLILVSRAEITPLKEAERASKELEDIGVKNQILIIN
GVLQQCDDYLSKSIYDKQQNSLKDIPEGLKNIKTFEIPLRPYNITGLENVRSLLKDNYTVVDNEILNITEIPKLNSIIED
LYKNDKKVIFTMGKGGVGKTTIAAAIALGLSKKGKKVHLTTTDPAGHLKFVLDESYGISLSNIDEKEELEKYKEEVLKKA
RENNMSDEDIAYVEEDLRSPCTQEIAVFRAFAEIVERSENEVVVIDTAPTGHTLLLLESTESYNREIVRSEGDIPESVIK
LLPKLKNHKDTEVIIVTLAETTPIYEAMRLQEDLNRAEIYSNWWVINSSLYATNTSNEILKAKASNEIRWINKVDKISNG
NFAVIKWKPEEIKDDRLKELLD

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
SH0111 YP_252026.1 arsenical pump-driving ATPase Not tested SCCmec Protein 3e-118 47
arsA2 YP_001007632.1 arsenical pump-driving ATPase Not tested YAPI Protein 2e-115 44

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
arsA YP_001921792.1 arsenical pump-driving ATPase ArsA BAC0030 Protein 5e-117 44
arsA YP_001921792.1 arsenical pump-driving ATPase ArsA BAC0572 Protein 2e-114 44
arsA YP_001921792.1 arsenical pump-driving ATPase ArsA BAC0571 Protein 4e-117 43