Gene Information

Name : CLH_0205 (CLH_0205)
Accession : YP_001919641.1
Strain : Clostridium botulinum Alaska E43
Genome accession: NC_010723
Putative virulence/resistance : Virulence
Product : negative regulator of genetic competence ClpC/mecB
Function : -
COG functional category : O : Posttranslational modification, protein turnover, chaperones
COG ID : COG0542
EC number : -
Position : 217541 - 219985 bp
Length : 2445 bp
Strand : +
Note : identified by match to protein family HMM PF00004; match to protein family HMM PF02151; match to protein family HMM PF02861; match to protein family HMM PF07724; match to protein family HMM PF07728

DNA sequence :
TTGAGTATGGATTTTAATAAATTTACAGAAAGAACTCAATCAATAATACTAGAAGCACAAATTGAATCACAAGAATTTAA
ACATGGATATGTAGGTACAGAACATTTATTATTGGGTTTAGTAAAAGAAAAAGGAAATCAATCTAAAATATTAAATGAAT
TTGGAATTGATGATGAAATAGTAAGAGATATGATAAGTAGATATTTGGGCTATGGTGAATTACAAATGCCTGAAGATGAT
ATATTGTTAACACCTAGAGCAAAAAGACTTCTTGATGAAAGCTTTATAGAGGCTAAAAAATTTAGTCATAAAAATGTTAG
CCCAGAACATATATTAATGGCATTACTTAATCAAGAAGAAGGAATGGCATATACTATATTAAAAAATTTAAAATTAGATT
TCAAAGAAATAAAAGATAAATTGTTTGTATTTTTAAATGGTCAGTATGTAGATGAAAATGAAGAAGTTAAGTCTCCAAAA
TCAGAAAAAAATAAAACGCCTATGTTAGATAAATACGGACGAGATTTAACTCAATTTGCAAGAGATGGTGGATTAGATCC
TGTTATTGGAAGAGATTCAGAAAATCAAAGGGTTTTAGAAATATTATGTAGAAGAATAAAAAACAATCCTTGTTTAATAG
GTGAACCAGGAGTTGGAAAAACAGCAGTAATTGAGGGATTAGCACAGAGAATTGTAGAAGGTAATATCCCTGAAATACTA
AGAGATAAGAGAATAGTTTCTCTTGATCTAACGGCATTACTTGCAGGTGCTAAATATAGAGGGGAATTTGAAGATAGATT
AAAGAAGGTAATGCTTGAAATAGAAAAAGATAAAAGCATTATAATATTCATAGATGAGATTCATACAATAATAGGTGCAG
GTGCAGCAGAAGGTGCAATAGATGCTTCAAATATATTAAAGCCAGCACTTTCTAGAGGACAAATTCAATGTATAGGTGCA
ACAACTATAAATGAATATAGAAAACATATAGAAAAGGATTCTGCATTAGAAAGAAGATTTCAACCAGTAAATGTTGGTGA
GCCATCAAAAGATGAAACACTAATAATACTAAAGGGATTAAGAGTAAAGTATGAAGAGCATCATAATGTTAATATTACAG
AAAAAGCATTGGAAGCTGCTGTAGATTTATCTGATAGATATGTTACAGACAGATTTATGCCAGATAAAGCTATTGATTTA
ATTGATGAGGCATGTGCTAAAGTTAGAATAAAAAATTTAATTCCTCCTACTAATTTAAAATCAATGGAAGACAAAATTAA
AGAGATAACTAAGGAAAAAGAAGAGTGTATTAGAGTTCAAGATTTCGAAAAAGCAGCAGATATGAGGGATATTGAAAATA
ATTTAAAAGAAGAATTAGAGGCATTAAGAAAAGAATGGAGTGACAAAAATTCTAATAAATTATTGAATGTAGATGAGGAA
GATATAGCAGAAGTTGTATCAGCGTGGACTAAAATACCAGCTAAAAAGCTTACAGAAAAAGAGAGTGAAAAATTATTAAA
GCTTGAAAATATACTTGAAAAAAGAGTTATAGGTCAAACAGAAGCTGTTGAATCTATAGCTAAAGCTGTAAGAAGAGCTA
GAGTTGGGATAAAAGATCCTAATAGACCAATAGGAACATTTATATTTTTAGGACCTACAGGTGTTGGTAAAACAGAACTT
TCAAAGGCGTTAGCTGAAGCTATGTTTGGAGATGAAAACAGTATAATAAGAATAGATATGTCAGAATATATGGAAAGCAA
TTCAGTTTCTAAATTAATAGGTTCTCCTCCAGGTTATGTAGGATATGATGATGGTGGTCAATTAACAGAGGCTGTTAGAA
GAAAGCCTTATTCTGTAGTACTTTTAGATGAAATTGAAAAAGCTCATCAAGATGTATTTAATATATTGCTTCAAATTATG
GAGGATGGAAGACTTACAGATTCTCATGGAAAAGTAGTTAATTTTAAAAACACAATAGTTATAATGACTTCTAATGTAGG
AGCACATCAAATAAAGAAACAAAAAGCAATTGGATTTAATACAAGTGTTGATGAGAATTCGGAATATGAAAAGATGAAAG
ATAATGTTTTAGAAGAATTAAAGAGAAGCTTTAAACCGGAATTCTTGAATAGAATAGATGATACTATAGTATTCCATAAA
TTAAAAGAAGAGGATCTCTTAGATATAGTTGATTTAATGTTAAAATCTATTACCAAAAGACTTGAAAATAAAAATATACA
CTTAAATTTTGAAAAAGATAGTAAGAAATTCTTAATTAACAAAAGAGTTGATTTAAATTATGGGGCAAGACCATTAAGAA
GAATTATTACTAAAGAAGTAGAAGATAAATTAAGTGAAGAGATACTTTTAGGTAATATAAAAATTGGAGATAGAATCAAA
GTAAATGAATCAAAAGATAATTTGGTTTTTACAAAATTAGATTAA

Protein sequence :
MSMDFNKFTERTQSIILEAQIESQEFKHGYVGTEHLLLGLVKEKGNQSKILNEFGIDDEIVRDMISRYLGYGELQMPEDD
ILLTPRAKRLLDESFIEAKKFSHKNVSPEHILMALLNQEEGMAYTILKNLKLDFKEIKDKLFVFLNGQYVDENEEVKSPK
SEKNKTPMLDKYGRDLTQFARDGGLDPVIGRDSENQRVLEILCRRIKNNPCLIGEPGVGKTAVIEGLAQRIVEGNIPEIL
RDKRIVSLDLTALLAGAKYRGEFEDRLKKVMLEIEKDKSIIIFIDEIHTIIGAGAAEGAIDASNILKPALSRGQIQCIGA
TTINEYRKHIEKDSALERRFQPVNVGEPSKDETLIILKGLRVKYEEHHNVNITEKALEAAVDLSDRYVTDRFMPDKAIDL
IDEACAKVRIKNLIPPTNLKSMEDKIKEITKEKEECIRVQDFEKAADMRDIENNLKEELEALRKEWSDKNSNKLLNVDEE
DIAEVVSAWTKIPAKKLTEKESEKLLKLENILEKRVIGQTEAVESIAKAVRRARVGIKDPNRPIGTFIFLGPTGVGKTEL
SKALAEAMFGDENSIIRIDMSEYMESNSVSKLIGSPPGYVGYDDGGQLTEAVRRKPYSVVLLDEIEKAHQDVFNILLQIM
EDGRLTDSHGKVVNFKNTIVIMTSNVGAHQIKKQKAIGFNTSVDENSEYEKMKDNVLEELKRSFKPEFLNRIDDTIVFHK
LKEEDLLDIVDLMLKSITKRLENKNIHLNFEKDSKKFLINKRVDLNYGARPLRRIITKEVEDKLSEEILLGNIKIGDRIK
VNESKDNLVFTKLD

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
clpC YP_005163377.1 ATP-dependent Clp protease ATP-binding subunit Not tested Not named Protein 0.0 51

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
CLH_0205 YP_001919641.1 negative regulator of genetic competence ClpC/mecB VFG0079 Protein 0.0 55
CLH_0205 YP_001919641.1 negative regulator of genetic competence ClpC/mecB VFG0080 Protein 1e-133 50