Gene Information

Name : Nther_2677 (Nther_2677)
Accession : YP_001918820.1
Strain : Natranaerobius thermophilus JW/NM-WN-LF
Genome accession: NC_010718
Putative virulence/resistance : Resistance
Product : cystathionine gamma-synthase
Function : -
COG functional category : E : Amino acid transport and metabolism
COG ID : COG0626
EC number : 4.4.1.11
Position : 2885893 - 2887077 bp
Length : 1185 bp
Strand : +
Note : KEGG: cko:CKO_04984 hypothetical protein; TIGRFAM: methionine gamma-lyase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent protein; aromatic amino acid beta-eliminating lyase/threonine aldolase

DNA sequence :
TTGGCTAGAGAGTACAAGCATAAATTTGAGACTCGTGCCGTTCACGCTGATGAAGGTCACAAAAATGAGGTCGGTGCTCT
AAGAACTCCTATATACCAAAGCTCAACCTTCGTATTTGACAACGTGGAACAAGGTGCCAATAGATTTTGTGGAGAAGAAG
CAGGATATATTTATACCAGGCTAGGTAATCCCACACAAAGAGATTTGGAAAAGCAAATGGCCAATTTAGAAGGAGCTGAG
GACGCTATTGCTGTTGGGTCTGGAATGGCGGCTGTTTCCGCTGTTGTGATGAATTTATTAAATAGTGGAGACCATATGGT
AGCATCTGACACACTTTACGGTTGCACACATTCACTATTTGACGAATTATTGCCCAACTGGAATGTGGACGTAACTTTTG
TCGATATGACAGATCCCGATAATGTCCGAAATGCCATCAGGAACAGTACCAAAGTAATTTATACAGAAACCCCTGCAAAT
CCTACCCTTTCAATCATTGACCTAAACGAAATTGTTAATATAGCCAAGGATAAAAATATCACTACTATTACTGATAATAC
TTTTATGACCCCCTATTTACAAAGACCTATTGAAATGGGAATAGATGTGGTAATTCACAGTGCCACCAAGTATCTAGGTG
GTCACGGAGATACTATTGGTGGTGTGATTGTGGGCTCCCAGGAACTTATGAACGAACTTAGAATGACTACAGTCAAAGAT
TTTGGCGGCATTATTGGTCCTTTTGATGCCTTTCTACTCTTACGGGGTATTAAAACCTTGACAGTTCGAATGGATAAGAT
TTGTGAGAATGCCAAAAAGATAGCCAAGTTTTTAGAAGAACATTCAGAAGTAGAAAGAGTTTACTATCCAGGCTTAGAAA
GCCATCCTCAACACTCCCTTGCTAAAAAACAAATGGGAGATTTCGGTGGCATGATCACCTTTGAACTAAAAGGTGGCTAT
GAAGCAGGTAAAAAACTGATGAACAGTGTAGAACTTTGTGTACTGGCCGTTAGCTTGGGCGATGTGGATACCTTAATTCA
GCATCCCGCTTCCATGACTCACTATGTAGTACCTCCAGAAGAAAGAGAAAAAGCAGGCATCACCGACGGCCTAGTCAGGC
TGTCGGTAGGAATTGAAGATCCGGAAGATGTCATGAATGATTTAAAACAAGGCATGGAAAGTTAA

Protein sequence :
MAREYKHKFETRAVHADEGHKNEVGALRTPIYQSSTFVFDNVEQGANRFCGEEAGYIYTRLGNPTQRDLEKQMANLEGAE
DAIAVGSGMAAVSAVVMNLLNSGDHMVASDTLYGCTHSLFDELLPNWNVDVTFVDMTDPDNVRNAIRNSTKVIYTETPAN
PTLSIIDLNEIVNIAKDKNITTITDNTFMTPYLQRPIEMGIDVVIHSATKYLGGHGDTIGGVIVGSQELMNELRMTTVKD
FGGIIGPFDAFLLLRGIKTLTVRMDKICENAKKIAKFLEEHSEVERVYYPGLESHPQHSLAKKQMGDFGGMITFELKGGY
EAGKKLMNSVELCVLAVSLGDVDTLIQHPASMTHYVVPPEEREKAGITDGLVRLSVGIEDPEDVMNDLKQGMES

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
SAR0460 YP_039909.1 Cys/Met metabolism PLP-dependent enzyme Not tested vSa¥á Protein 2e-71 44
SAS0418 YP_042545.1 Cys/Met metabolism PLP-dependent enzyme Not tested vSa¥á Protein 2e-72 43
metB YP_281510.1 cystathionine beta-lyase Not tested Not named Protein 3e-61 41

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
Nther_2677 YP_001918820.1 cystathionine gamma-synthase BAC0207 Protein 1e-87 49