Gene Information

Name : Nther_2245 (Nther_2245)
Accession : YP_001918399.1
Strain : Natranaerobius thermophilus JW/NM-WN-LF
Genome accession: NC_010718
Putative virulence/resistance : Resistance
Product : methionine gamma-lyase
Function : -
COG functional category : E : Amino acid transport and metabolism
COG ID : COG0626
EC number : 4.4.1.11
Position : 2381959 - 2383131 bp
Length : 1173 bp
Strand : -
Note : KEGG: sth:STH832 cystathionine gamma-lyase; TIGRFAM: methionine gamma-lyase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent protein

DNA sequence :
ATGTCGAGTCAAAATTTTGAGACAAGGATTTTACATGCCGATGAAGGTCACAAGAATGATGCAGGTGCACTTAGGGTACC
AATTTATCAAAGCTCAACCTTTGTATTTGACAGTGTTGAGCAGGGTGCGTCCAGGTTTACAGGTGAAGAAGATGGCTACA
TTTACACCAGATTAGGTAATCCCACTCAATCAAGCTTAGAAAAACTTATGGCAAATTTAGAGGGAGGAGAAGACGCTCTC
GCCGTGAGTTCAGGCATGGCAGCTATCTCTTCTGCTATCATGAGTTTACTCAGCTGTGGGGATCATATGATCGTTTCAAA
TCCTCTGTATGGATGTACTCATTCTTTTTGTGTGGATATATTGCCTGAATGGGGTATTGAAGTGACTTTTGTCGATATGA
CAGATCCAGACAATATTTACAAAGCGATAAAAAGTAATACCAAAGTTATTTACACCGAGACACCGGCTAATCCTACCTTA
TATCTAATAGATTTAGAACGAGTTGCGAAAATTGCCAAGGAGAAAAATCTTACCACAATAACTGACAATACGTTCATGAG
CCCATATCTACAAAGACCACTTGAGTTGGGCATAGATGTGGTTGTCCATAGTGCTACTAAATATCTCTGTGGGCATGGTG
ATACTGTAGCTGGAATGATAGTAGGACCAAAAAAGATAATTGACAACATTAATGGGACTACAATTAAAAACTTCGGTGGA
ATTATAGGCCCCTTTGATGCTTTCTTGATTTTGAGAGGAGTTAAGACACTAACACTTCGGATGGACAAGATTTGCGAAAA
TGCCAAAAAAATAGCTGAATTTCTCGATAATCACCCTGCCATAGAAAAAGTGTATTATCCAGGACTGGAAAGTCACCCTC
AACACGAACTAGCTAAGCGACAGATGAGAAACTTTGGTGGAATCGTGACCTTCGAACTTGCTGATGGCTATGAAGCCGGG
AAAAAACTGCTTAACAATGTTGAAGTTTGTACTCTAGCGACTAGTTTAGGTGATGTAGATACATTGATTCAGCATCCAGC
TTCCATGACTCATTATGTAGTTCCTAAAGAAGAACGTGAGAAAAATGGTATTACTGATGGATTAGTAAGACTTTCTGTAG
GAATAGAAAATGTCAACGATATTATTGAGGATTTAAAACAAGGATTGAACTAA

Protein sequence :
MSSQNFETRILHADEGHKNDAGALRVPIYQSSTFVFDSVEQGASRFTGEEDGYIYTRLGNPTQSSLEKLMANLEGGEDAL
AVSSGMAAISSAIMSLLSCGDHMIVSNPLYGCTHSFCVDILPEWGIEVTFVDMTDPDNIYKAIKSNTKVIYTETPANPTL
YLIDLERVAKIAKEKNLTTITDNTFMSPYLQRPLELGIDVVVHSATKYLCGHGDTVAGMIVGPKKIIDNINGTTIKNFGG
IIGPFDAFLILRGVKTLTLRMDKICENAKKIAEFLDNHPAIEKVYYPGLESHPQHELAKRQMRNFGGIVTFELADGYEAG
KKLLNNVEVCTLATSLGDVDTLIQHPASMTHYVVPKEEREKNGITDGLVRLSVGIENVNDIIEDLKQGLN

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
SAR0460 YP_039909.1 Cys/Met metabolism PLP-dependent enzyme Not tested vSa¥á Protein 3e-70 44
SAS0418 YP_042545.1 Cys/Met metabolism PLP-dependent enzyme Not tested vSa¥á Protein 3e-71 44
metB YP_281510.1 cystathionine beta-lyase Not tested Not named Protein 2e-56 42

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
Nther_2245 YP_001918399.1 methionine gamma-lyase BAC0207 Protein 4e-83 48