Gene Information

Name : Nther_1160 (Nther_1160)
Accession : YP_001917331.1
Strain : Natranaerobius thermophilus JW/NM-WN-LF
Genome accession: NC_010718
Putative virulence/resistance : Resistance
Product : cystathionine gamma-synthase
Function : -
COG functional category : E : Amino acid transport and metabolism
COG ID : COG0626
EC number : 2.5.1.48
Position : 1228004 - 1229203 bp
Length : 1200 bp
Strand : +
Note : PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent protein; aromatic amino acid beta-eliminating lyase/threonine aldolase; Aluminium resistance family protein; KEGG: cko:CKO_04984 hypothetical protein

DNA sequence :
ATGGAAAAACGTAGGTTATCATTTAATGCTAAGGCTATTCATGCAGGTAGTGAACCCTGCCCTACTACAGGAGCTCATGT
AGCGCCAGTTTACCGGACTTCAACCTTTGTTATTGATAATGTCGAGAGAGCTATCAGAATAGGCTATGGAGAAGAGGAAG
GATATTCTTATGGTAGATTTGGAAACCCCACGGTAGACGCTTTACAAGAAAAAATTGCTTCTCTTGAAAATGCTGAAGCA
GCTTTGGCTACGGCTTCAGGCATGGCAGCAATTTCTACTGCATTAATGGCAGAACTACAAGCTGGTGACCATATTGTGAC
AGGTGATATCATCTATGGTTGTACCTATGGTTTTGTCCGCGATCTTTTACCTCAATACGGAATTGAAGTGACTATGGTTG
ATACAACAGATCCTAAAAACATTGAAGAAGCAATCAAACCAAATACTAAAATAGTATATATTGAAACTCCTTCAAATCCT
GTATTGGGGATCACTGATATTGAAAAATCAGCTGAACTTGCACATGCTAATGGTGCTAAACTGTTTGTTGACAATACTTG
GGCAACTCCTTATCTACAAAATCCACTAAATATAGGAGCAGATGTTGTACTTCATAGTGCAACAAAATACTTGAATGGTC
ATGGAGACATTGTTGGTGGAGCTATAGTAGGTTCAAAAGAGTTAATGGATAAAATCAAAGCACCATATCTTGAATTCTTC
GGTGGAATTATGTCTCCAATGGATGCAGCAGAAGTATCTAAAGGAATTAAAACACTAGGAGTGCGAATGGAAAAACACTG
CCAAAACGCTAAAAAGATAGCTGAATTCCTAGAAGGCCATCATATGGTAGAAAGAGTTCTATACCCTGGTGTTGAAACTC
ATCCGCAACACGAGCTAGCCAAAAAGCAGATGAAAGATTTTGGTGGCATGATGAGTTTTGATGTCAAAGGTGGTGCAAAG
GCAGGAAAAGCCCTTATGAACAGTGTTGAACTAGTTAGTCTTGCTACTAGTCTTGGCTGTGTAGATTCTCTGATTCAGCA
TTCACCTTCTATGAGTCATGCCACAATGAGTAAAGAAGAACGAGAGCGTGTAGGTATTACTGAAGGACAAGTGCGATTAT
CTGTAGGAATTGAAGAGCCTGAAAATGTCATTGCTGATCTAAAACAAGCCCTAGAGCAAGTTGAAAAAGTTATAGATTAA

Protein sequence :
MEKRRLSFNAKAIHAGSEPCPTTGAHVAPVYRTSTFVIDNVERAIRIGYGEEEGYSYGRFGNPTVDALQEKIASLENAEA
ALATASGMAAISTALMAELQAGDHIVTGDIIYGCTYGFVRDLLPQYGIEVTMVDTTDPKNIEEAIKPNTKIVYIETPSNP
VLGITDIEKSAELAHANGAKLFVDNTWATPYLQNPLNIGADVVLHSATKYLNGHGDIVGGAIVGSKELMDKIKAPYLEFF
GGIMSPMDAAEVSKGIKTLGVRMEKHCQNAKKIAEFLEGHHMVERVLYPGVETHPQHELAKKQMKDFGGMMSFDVKGGAK
AGKALMNSVELVSLATSLGCVDSLIQHSPSMSHATMSKEERERVGITEGQVRLSVGIEEPENVIADLKQALEQVEKVID

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
SAR0460 YP_039909.1 Cys/Met metabolism PLP-dependent enzyme Not tested vSa¥á Protein 1e-64 43
SAS0418 YP_042545.1 Cys/Met metabolism PLP-dependent enzyme Not tested vSa¥á Protein 9e-66 43
metB YP_281510.1 cystathionine beta-lyase Not tested Not named Protein 2e-56 41

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
Nther_1160 YP_001917331.1 cystathionine gamma-synthase BAC0207 Protein 4e-82 47