Gene Information

Name : HPSH_04165 (HPSH_04165)
Accession : YP_001910298.1
Strain : Helicobacter pylori Shi470
Genome accession: NC_010698
Putative virulence/resistance : Virulence
Product : cag pathogenicity island protein CagE
Function : -
COG functional category : U : Intracellular trafficking, secretion and vesicular transport
COG ID : COG3451
EC number : -
Position : 809382 - 812327 bp
Length : 2946 bp
Strand : +
Note : COG3451 Type IV secretory pathway, VirB4 components

DNA sequence :
GTGGCAAGCAAGCAAGCTGACGAACAAAAAAAGCTAATCATAGAGCAAGAGGTTCAAAAGCGGCAGTTTCAAAAAATAGA
AGAGCTTAAAGCAGACATGCAAAAAGGCGTCAATCCCTTTTTTAAAGTCTTGTTTGATGGGGGGAATAGGTTGTTTGGTT
TCCCTGAAACTTTTATTTATTCCTCTATATTTATATTGTTTGTAACAATTGTATTATCTGTTATTCTTTTTCAAGCCTAT
GAACCTGTTTTGATTGTGGCGATTGTTATTGCGCTTGTAGCTCTTGGATTCAAGAAAGATTATAGGCTTTATCAAAGAAT
GGAGCGAGCGATGAAATTTAAAAAACCTTTTTTGTTTAAGGGCGTGAAAAACAAAGCATTCATGAGCATTTTTTCCATGA
AGCCTAGTAAAGAAATGGCTAATGACATCCACTTAAATCCAAACAGAGAAGACAGACTTGTGAGTGCTGCAAACTCCTAT
TTGGCGAATAACTATGAATGTTTTTTAGATGATGGGGTGATCCTTACTAACAACTATTCTCTTTTAGGCACAATCAAATT
GGGGGGCATTGATTTTTTAACCACTTCCAAAAAAGATCTCATAGAGTTACACGCTTCTATTTATAGCGTTTTTAGGAATT
TTGTTACCCCTGAATTCAAATTCTATTTTCACACTGTTAAAAAGAAAATCGTTATTGATGAAACCAATAGGGACTATAGT
CTTGCTTTTTCTAATGATTTTATGCGAGCCTATAATGAGAAGCAAAAGAGAGAAAGTTTTTATGATATTAGTTTTTTTCT
GACCATAGAGCAAGATTTATTAGACACTCTCAATGAACCTGTTATGAATAAAAAGCATTTTGCAGACAATAATTTTGAAG
AGTTTCAAAGGATTATTAGAGCCAAGCTTGAAAACTTCAAGGATAGGATAGAGCTCATAGAAGAGCTATTGAGTAAATAC
CACCCCACTAGATTGAAAGAATATATTAAAGATGGGGTTGTTTATTCCAAACAATGCGAGTTTTACAATTTTCTTGTGGG
AATGAATGAAGCCCCTTTTATTTGCAACCGGAAAGATTTGTATCTGAAAGAGAAAATGCATGGTGGGGTGAAAGAAGTTT
ATTTTGCCAATAAGCATGGAAAAATCTTAAATGATGATTTGAGTGAAAAATATTTTAGCGCTATTGAGATTAGTGAATAC
GCCCCTAAATCACAGAGCGATTTGTTTGACAAGATCAACGCTCTAGACAGCGAATTTATCTTTATGCATGCTTATTCGCC
TAAAAACTCACAGGTTTTAAAGGATAAACTAGCTTTCACCTCTAGAAGGATTATTATTAGTGGAGGTTCTAAAGAGCAGG
GCATGACTTTAGGTTGCTTGAGCGAATTAGTGGGTAATGGTGATATTACGCTAGGCAGTTATGGTAATTCTTTAGTGCTG
TTTGCTGATAGCTTTGAAAAAATGAAACAAAGCGTCAAGGAATGTGTCTCTAGTCTTAACGCTAAAGGTTTTTTAGCCAA
CGCAGCGACTTTCTCTATGGAAAATTACTTTTTTGCCAAACATTGCTCTTTTATTACGCTTCCTTTTATTTTTGATGTAA
CTTCTAATAATTTTGCTGATTTTATCGCTATGAGAGCGATGAGTTTTGATGGCAATCAAGAGAATAACGCTTGGGGTAAT
AGCGTCATGACGCTAAAAAGCGAGATCAATTCGCCTTTTTATCTGAACTTCCACATGCCTACTGATTTTGGTTCAGCTTC
AGCAGGACACACTTTGATACTTGGCTCAACCGGTTCAGGTAAGACAGTGTTTATGTCAATGACTCTAAACGCTATGGGAC
AATTTGCTCACAATTTTCCTGCTAATGTCAGCAAAGACAAGCAAAAGCTCACTATGGTCTATATGGATAAAGATTATGGC
GCTTATGGGAATATTGTCGCAATGGGTGGGGAGTATGTCAAAATTGAGCTAGGGACAGATACAGGATTAAACCCTTTTGC
TTGGGCGGCTTGTGTGCAAAAAACAAATGCAACAATGGAGCAAAAACAAACAGCTATTTCTGTTGTCAAAGAGCTTGTGA
AAAACTTAGCAACCAAAAGCGATGAAAAAGATGAAAATGGCAACAGTATCTCTTTTAGCCTAGCTGATTCTAATACGCTT
GCAGCGGCAGTAACCAACCTTATCACAGGAGATATGAACCTAGATTATCCCATCACTCAACTTATTAATGCTTTCGGAAA
AGACCACAATGATCCTAATGGGCTTGTCGCGCGATTAGCGCCTTTTTGTAAATCAACCAATGGTGAATTTCAATGGCTTT
TTGATAATAAAGCAACAGATCGCTTAGATTTTTCAAAAACGATTATTGGCGTTGATGGGTCAAGTTTCCTAGACAATAAT
GATGTTTCGCCCTTTATTTGTTTTTACCTTTTCGCTCGTATTCAAGAGGCAATGGATGGGCGTAGATTTGTCTTAGATAT
TGATGAAGCTTGGAAATATTTAGGCGATCCAAAGGTCGCTTATTTTGTAAGAGACATGCTAAAAACTGCAAGGAAAAGAA
ACGCTATTGTTAGACTTGCAACTCAAAGCATCACTGATCTTTTGGCTTGCCCTATTGCTGATACTATTAGAGAACAATGC
CCTACAAAGATTTTTTTGAGAAACGATGGGGGCAATCTTTCTGATTACCAAAGATTAGCTAATGTTACAGAAAAAGAATT
TGAAATCATCACTAAGGGGCTAGATAGGAAAATTCTCTACAAACAAGATGGAAGCCCTAGCGTTATCGCTAGTTTTAATT
TGAGAGGCATTCCTAAAGAATATTTGAAAATTTTATCCACAGATACTGTATTTGTCAAAGAAATTGACAAGATTATACAA
AATCGTAGTATCATAGATAAATATCAGGCCTTGAGGCAAATGTATCAACAAATAAAGGAGTATTAA

Protein sequence :
MASKQADEQKKLIIEQEVQKRQFQKIEELKADMQKGVNPFFKVLFDGGNRLFGFPETFIYSSIFILFVTIVLSVILFQAY
EPVLIVAIVIALVALGFKKDYRLYQRMERAMKFKKPFLFKGVKNKAFMSIFSMKPSKEMANDIHLNPNREDRLVSAANSY
LANNYECFLDDGVILTNNYSLLGTIKLGGIDFLTTSKKDLIELHASIYSVFRNFVTPEFKFYFHTVKKKIVIDETNRDYS
LAFSNDFMRAYNEKQKRESFYDISFFLTIEQDLLDTLNEPVMNKKHFADNNFEEFQRIIRAKLENFKDRIELIEELLSKY
HPTRLKEYIKDGVVYSKQCEFYNFLVGMNEAPFICNRKDLYLKEKMHGGVKEVYFANKHGKILNDDLSEKYFSAIEISEY
APKSQSDLFDKINALDSEFIFMHAYSPKNSQVLKDKLAFTSRRIIISGGSKEQGMTLGCLSELVGNGDITLGSYGNSLVL
FADSFEKMKQSVKECVSSLNAKGFLANAATFSMENYFFAKHCSFITLPFIFDVTSNNFADFIAMRAMSFDGNQENNAWGN
SVMTLKSEINSPFYLNFHMPTDFGSASAGHTLILGSTGSGKTVFMSMTLNAMGQFAHNFPANVSKDKQKLTMVYMDKDYG
AYGNIVAMGGEYVKIELGTDTGLNPFAWAACVQKTNATMEQKQTAISVVKELVKNLATKSDEKDENGNSISFSLADSNTL
AAAVTNLITGDMNLDYPITQLINAFGKDHNDPNGLVARLAPFCKSTNGEFQWLFDNKATDRLDFSKTIIGVDGSSFLDNN
DVSPFICFYLFARIQEAMDGRRFVLDIDEAWKYLGDPKVAYFVRDMLKTARKRNAIVRLATQSITDLLACPIADTIREQC
PTKIFLRNDGGNLSDYQRLANVTEKEFEIITKGLDRKILYKQDGSPSVIASFNLRGIPKEYLKILSTDTVFVKEIDKIIQ
NRSIIDKYQALRQMYQQIKEY

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
cagE YP_003728720.1 cag pathogenicity island protein E Virulence cag PAI Protein 0.0 99
cagE BAD51901.1 cag pathogenicity island protein E Virulence cag PAI Protein 0.0 99
cagE AAF80209.1 CagE Virulence cag PAI Protein 0.0 99
cagE BAD51896.1 cag pathogenicity island protein E Virulence cag PAI Protein 0.0 99
cagE YP_005774527.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 99
HP0544 BAD14015.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 99
cagE BAD51923.1 cag pathogenicity island protein E Virulence cag PAI Protein 0.0 99
HP0544 BAD14042.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 99
HP0544 BAD13960.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 99
cagE BAD51918.1 cag pathogenicity island protein E Virulence cag PAI Protein 0.0 99
cagE BAD51893.1 cag pathogenicity island protein E Virulence cag PAI Protein 0.0 99
cag23 AAR03878.1 Cag23 Virulence cag PAI Protein 0.0 99
cagE BAD51911.1 cag pathogenicity island protein E Virulence cag PAI Protein 0.0 99
cagE BAD51913.1 cag pathogenicity island protein E Virulence cag PAI Protein 0.0 99
HP0544 BAD14069.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 99
cagE BAD51910.1 cag pathogenicity island protein E Virulence cag PAI Protein 0.0 99
HP0544 BAD13932.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 99
cagE YP_005775744.1 DNA transfer protein Not tested cag PAI Protein 0.0 99
cagE BAD51895.1 cag pathogenicity island protein E Virulence cag PAI Protein 0.0 99
cagE BAD51914.1 cag pathogenicity island protein E Virulence cag PAI Protein 0.0 99
cagE BAD51909.1 cag pathogenicity island protein E Virulence cag PAI Protein 0.0 99
cagE BAD51899.1 cag pathogenicity island protein E Virulence cag PAI Protein 0.0 99
cagE BAD51922.1 cag pathogenicity island protein E Virulence cag PAI Protein 0.0 99
cagE BAD51907.1 cag pathogenicity island protein E Virulence cag PAI Protein 0.0 99
HP0544 BAD13905.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 99
cagE BAD51917.1 cag pathogenicity island protein E Virulence cag PAI Protein 0.0 99
cagE BAD51904.1 cag pathogenicity island protein E Virulence cag PAI Protein 0.0 99
cagE BAD51915.1 cag pathogenicity island protein E Virulence cag PAI Protein 0.0 99
cagE BAD51892.1 cag pathogenicity island protein E Virulence cag PAI Protein 0.0 99
cagE BAD51927.1 cag pathogenicity island protein E Virulence cag PAI Protein 0.0 99
cagE BAD51930.1 cag pathogenicity island protein E Virulence cag PAI Protein 0.0 99
cagE BAD51921.1 cag pathogenicity island protein E Virulence cag PAI Protein 0.0 99
cagE BAD51906.1 cag pathogenicity island protein E Virulence cag PAI Protein 0.0 99
cagE BAD51920.1 cag pathogenicity island protein E Virulence cag PAI Protein 0.0 99
cagE BAD51926.1 cag pathogenicity island protein E Virulence cag PAI Protein 0.0 99
cagE BAD51916.1 cag pathogenicity island protein E Virulence cag PAI Protein 0.0 99
cagE BAD51912.1 cag pathogenicity island protein E Virulence cag PAI Protein 0.0 99
HP0544 BAD13850.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 99
cagE BAD51931.1 cag pathogenicity island protein E Virulence cag PAI Protein 0.0 99
HP0544 BAD13823.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 99
cagE NP_223210.1 DNA transfer protein Virulence cag PAI Protein 0.0 99
cagE BAD51903.1 cag pathogenicity island protein E Virulence cag PAI Protein 0.0 99
cagE BAD51925.1 cag pathogenicity island protein E Virulence cag PAI Protein 0.0 99
cag23 AAR03906.1 Cag23 Virulence cag PAI Protein 0.0 99
HP0544 BAD13877.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 99
cag23 AAR03936.1 Cag23 Virulence cag PAI Protein 0.0 99
cagE BAD51898.1 cag pathogenicity island protein E Virulence cag PAI Protein 0.0 99
cagE AGC69804.1 cag pathogenicity island protein E Virulence cag PAI Protein 0.0 99
cagE BAD51894.1 cag pathogenicity island protein E Virulence cag PAI Protein 0.0 99
cagE YP_005777285.1 DNA transfer protein Virulence cag PAI Protein 0.0 99
cagE BAD51928.1 cag pathogenicity island protein E Virulence cag PAI Protein 0.0 99
cagE BAD51919.1 cag pathogenicity island protein E Virulence cag PAI Protein 0.0 99
cagE BAD51900.1 cag pathogenicity island protein E Virulence cag PAI Protein 0.0 99
cag23 AAR03967.1 Cag23 Virulence cag PAI Protein 0.0 99
cagE BAD51891.1 cag pathogenicity island protein E Virulence cag PAI Protein 0.0 99
HP0544 BAD13796.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 99
cagE BAD51897.1 cag pathogenicity island protein E Virulence cag PAI Protein 0.0 99
HP0544 NP_207340.1 cag pathogenicity island protein (cag23) Virulence cag PAI Protein 0.0 99
cagE BAD51902.1 cag pathogenicity island protein E Virulence cag PAI Protein 0.0 99
cagE BAD51924.1 cag pathogenicity island protein E Virulence cag PAI Protein 0.0 99
cagE BAD51932.1 cag pathogenicity island protein E Virulence cag PAI Protein 0.0 99
cagE BAD51905.1 cag pathogenicity island protein E Virulence cag PAI Protein 0.0 99
cagE BAD51908.1 cag pathogenicity island protein E Virulence cag PAI Protein 0.0 99
HP0544 BAD13987.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 99
cagE BAD51929.1 cag pathogenicity island protein E Virulence cag PAI Protein 0.0 99
cagE YP_005779049.1 DNA transfer protein Not tested cag PAI Protein 0.0 99

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
HPSH_04165 YP_001910298.1 cag pathogenicity island protein CagE VFG0303 Protein 0.0 99