Gene Information

Name : HPSH_01375 (HPSH_01375)
Accession : YP_001909757.1
Strain : Helicobacter pylori Shi470
Genome accession: NC_010698
Putative virulence/resistance : Virulence
Product : ATP-dependent protease binding subunit ClpB
Function : -
COG functional category : O : Posttranslational modification, protein turnover, chaperones
COG ID : COG0542
EC number : -
Position : 257578 - 260148 bp
Length : 2571 bp
Strand : +
Note : COG0542 ATPases with chaperone activity, ATP-binding subunit

DNA sequence :
ATGAATTTATTTGAAAAAATGACTGACCAATTGCATGAAACTTTAGACAGCGCGCTCGCTCTAGCTTTACACCATAAAAA
CGCTGAAGTAACGCCCTTGCACATGCTTTTTGTCATGCTCAATAACTCCCAAGGCATCCTCATTCAAGCCTTACAAAAAA
TGTCTGTGGATATTCAAGCCTTAAGGCTTAGCGTTCAAAGCGAGTTGGATAAGTTTGTTAAAGTTTCACAAATCAACAAG
CAAAATATCCAGTTAAACCAAGCTCTAATCCAAAGTTTAGAAAACGCTCAAGGCTTGATGGCTAAAATGGGCGATTCTTT
TATCGCTACAGACGTGTATCTTTTGGCGAACATGAGCCTTTTTGAAAGCGTTCTAAAACCTTATTTAGACACTAAGCAAT
TGCAAAAAACTTTAGAGTCTTTGAGAAAGGGCGCGACTATCCAAAGTAAAAACGATGATTCTAATTTGGAAAGTTTGGAA
AAATTTGGCATTGATTTGACGCAAAAAGCCTTAGAAAATAAGCTCGATCCGGTGATTGGGAGGGATGAAGAAATCATTCG
CATGATGCAAATTTTGATAAGAAAAACAAAAAATAACCCTATTTTACTAGGTGAGCCTGGAGTGGGGAAAACGGCGGTTG
TGGAGGGTTTGGCTCAACGCATTGTGAATAAGGAAGTGCCTAAAACGCTTTTAAACAAACGAGTCGTCGCTTTAGATTTA
AGCTTATTGGTGGCTGGAGCCAAATACAGAGGCGAGTTTGAAGAGCGCTTGAAAAAGGTGATTGAAGAAGTTAAAAAAAG
TGCGAATGTGATTTTATTCATTGATGAAATCCACACGATTGTAGGGGCTGGGGCTAGTGAGGGGGGCATGGATGCGGCTA
ATATTTTAAAACCCGCACTCGCTAGGGGGGAATTGCACACGATTGGAGCGACCACTTTGAAAGAATACCGCAAGTATTTT
GAAAAAGACATGGCGTTACAAAGGCGTTTCCAACCCATTTTACTCAATGAGCCTAGCATCAATGAAGCTTTACAGATTTT
AAGGGGGTTAAAAGAAACTTTAGAAACGCACCATAATATCACTATCAATGACTCCGCGCTCATAGCGAGCGCCAAACTCT
CTAGCCGTTATATCACCGATAGGTTTTTACCCGATAAAGCGATTGATTTGATTGATGAGGGGGCGGCTCAATTAAAAATG
CAAATGGAATCAGAGCCGGCAAAGCTCTCTAGCGTTAAGCGCTCCATTCAAAGATTGGAAATGGAAAAACAAGCCCTTGA
AATGGAAAAAAAAGAGAGCAGTGCCAAACGCATGCAAGAAATCCTTAAAGAATTGAGCGATTTGAAAGAAGAAAAAATCC
AATTAGAAGCGCAATTTGAAAACGAAAAAGAAGTGTTTAGAGAAATTTCACGCTTGAAAATGGAAACGGAAAGCTTGAAA
AAAGAGGCTGAGAGGTTTAAGCGCAATGGGGATTACCAGCAAGCGGGTGAAATTGAATACTCTAAAATCCCTGAAAATAA
AAAGAAAGAAGAAGAATTGCAGCACAAATGGGAAGCGATGCAACAAAACGGGGCGTTATTGCAAAACGCTTTAACCGAAA
ACAACATCGCTGAGATCGTGAGCCAATGGACGCATATCCCGGTCCAAAAAATGCTCCAGAGCGAAAAAAATAGGGTTTTA
AACATTGAAAGCGAATTGCAAAAAAGAGTGGTGGGGCAAGAAAAAGCGATCAAAGCGATCGCTAAAGCGATTAAAAGGAA
TAAGGCCGGGCTTAGCGATAGCAATAAACCCATAGGGAGTTTTCTCTTTTTAGGGCCAACGGGCGTGGGTAAAACCGAGA
GCGCTAAAGCCTTGGCGCAATTCTTGTTTGATAGCGATAAAAATCTTATAAGAATTGACATGAGCGAATACCTAGAAAAG
CATGCCGTAAGCCGTCTTATTGGGGCCGCTCCTGGGTATGTGGGCTATGAAGAAGGCGGGCAATTGACCGAAGCGGTGCG
CAGAAAACCCTATAGCGTGGTGCTGTTAGATGAAGTGGAAAAAGCCCATCCGGATGTGTTTAACCTCTTGTTGCAGGTTT
TAGATGAAGGGCATTTAACCGATAGTAAGGGCGTGAGGGTGGATTTCAAAAACACGATCTTGATTTTAACCAGCAATGTG
GCTAGCGGCGCGCTTTTGGAAGAAAATTTGAGTGAAGCCGATAAACAAAAAGCGATCAAAGAGAGCTTGAGGCAATTCTT
CAAACCGGAATTTTTAAACCGCTTAGATGAAATCATCTCCTTTAACGCCCTAGATAGCCATGCTGTCGCTAATATCGTGG
GGATACTTTTTGAAAACATTCAAAAAAAAGCGCTTGAAAGAGGCATTAATATAACCCTAGACGAAGAGGCAAAAGAATTG
ATCGCTAAAGCGGGATTTGACAGATTTTATGGCGCTAGACCCTTGAAGCGTGCGCTCTATGAAATGGTAGAAGACAAACT
CGCTGAACTCATTTTAGAGGATAAAATTAAAGAGAATGGCAGCGTGGCGTTTGTGGCAGAAAATAACGAAATTGTGCCTA
AGATTAAGTGA

Protein sequence :
MNLFEKMTDQLHETLDSALALALHHKNAEVTPLHMLFVMLNNSQGILIQALQKMSVDIQALRLSVQSELDKFVKVSQINK
QNIQLNQALIQSLENAQGLMAKMGDSFIATDVYLLANMSLFESVLKPYLDTKQLQKTLESLRKGATIQSKNDDSNLESLE
KFGIDLTQKALENKLDPVIGRDEEIIRMMQILIRKTKNNPILLGEPGVGKTAVVEGLAQRIVNKEVPKTLLNKRVVALDL
SLLVAGAKYRGEFEERLKKVIEEVKKSANVILFIDEIHTIVGAGASEGGMDAANILKPALARGELHTIGATTLKEYRKYF
EKDMALQRRFQPILLNEPSINEALQILRGLKETLETHHNITINDSALIASAKLSSRYITDRFLPDKAIDLIDEGAAQLKM
QMESEPAKLSSVKRSIQRLEMEKQALEMEKKESSAKRMQEILKELSDLKEEKIQLEAQFENEKEVFREISRLKMETESLK
KEAERFKRNGDYQQAGEIEYSKIPENKKKEEELQHKWEAMQQNGALLQNALTENNIAEIVSQWTHIPVQKMLQSEKNRVL
NIESELQKRVVGQEKAIKAIAKAIKRNKAGLSDSNKPIGSFLFLGPTGVGKTESAKALAQFLFDSDKNLIRIDMSEYLEK
HAVSRLIGAAPGYVGYEEGGQLTEAVRRKPYSVVLLDEVEKAHPDVFNLLLQVLDEGHLTDSKGVRVDFKNTILILTSNV
ASGALLEENLSEADKQKAIKESLRQFFKPEFLNRLDEIISFNALDSHAVANIVGILFENIQKKALERGINITLDEEAKEL
IAKAGFDRFYGARPLKRALYEMVEDKLAELILEDKIKENGSVAFVAENNEIVPKIK

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
clpC YP_005163377.1 ATP-dependent Clp protease ATP-binding subunit Not tested Not named Protein 1e-140 41
STY0294 NP_454876.1 ClpB-like protein Not tested SPI-6 Protein 2e-101 41

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
HPSH_01375 YP_001909757.1 ATP-dependent protease binding subunit ClpB VFG0079 Protein 8e-159 43
HPSH_01375 YP_001909757.1 ATP-dependent protease binding subunit ClpB VFG2076 Protein 1e-111 42