Gene Information

Name : lysS (HPSH_00925)
Accession : YP_001909675.1
Strain : Helicobacter pylori Shi470
Genome accession: NC_010698
Putative virulence/resistance : Virulence
Product : lysyl-tRNA synthetase
Function : -
COG functional category : J : Translation, ribosomal structure and biogenesis
COG ID : COG1190
EC number : 6.1.1.6
Position : 173538 - 175043 bp
Length : 1506 bp
Strand : +
Note : class II; LysRS2; catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; in Methanosarcina barkeri, LysRS2 charges both tRNA

DNA sequence :
ATGTTTTCTAACCAATACATCCAACAACGCATCCATAAAGCCAACAGCTTGAGAGAAGAAGGGAAAAACCCTTATAAAAA
CGGCTTGAAACGAAGCCTTACAAACGCCGCTTTTTTAGAAAAATACGCTTATGTTAAGGGTTTAGAAGAGCCTAAAGACA
AGGAAAAATGCGAAAGTATTGTAGGGAGGGTCAAGCTTTTGCGTTTAATGGGTAAGGCTTGTTTTATTAAAATTGAAGAT
GAAAGCGCGATTTTGCAAGCTTATGTTTCGCAAAATGAATTGAACGATGAATTTAAAAGCCTGAAAAAGCATTTAGAAGT
GGGCGATATTGTGTTGGTGAAAGGTTTCCCTTTTGCTACCAAAACCGGTGAATTGAGCGTTCATGCCCTAGAATTTCATA
TTTTAAGCAAAACCATTGTGCCTTTACCCGAAAAATTCCATGGACTGAGCGATATAGAATTGCGTTACCGCCAGCGCTAC
TTGGATTTGATCGTCAATCCTAGCGTTAAAGATGTGTTTAAAAAACGCAGTTTGATTGTTTCTAGCGTGCGGAAATTCTT
TGAAACGGAAGGGTTTTTAGAAGTGGAAACCCCCATGATGCACCCCATTCCTGGCGGGGCGAACGCAAGGCCTTTTATCA
CTTACCATAACGCTTTAGAAATTGAAAGGTATTTAAGAATCGCTCCAGAATTATACCTCAAGCGCTTGATTGTGGGGGGT
TTTGAAGCGGTGTTTGAAATCAATCGCAATTTCAGGAATGAGGGCATGGATCACAGCCATAACCCCGAATTTACGATGAT
TGAGTTTTATTGGGCGTATCACACTTATGAAGATTTGATTGAACTTAGTAAGAGATTATTTGACTACTTGCTAAAGACTT
TGAACTTACCTTCAAAAATCATTTATAACGATATGGAAGTGGATTTCAACCAAACGAGCGTGATTTCCTATTTGGACGCT
TTAGAAACAATAGGGGGCATTAGTAAGGATATTTTAGAAAAAGAAGACAGGCTTTTGGCTTATTTGTTAGAGCAAAGTAT
TAAAGTAGAGCCAGATCTCACTTATGGCAAATTGCTCGCTGAAGCGTTTGATCATTTTGTAGAGCACCAGCTCATTAACC
CCACTTTTGTAACCCAATACCCCATTGAGATTAGCCCCTTAGCCAGACGCAACGATAGTAACCCTAATATTGCTGACAGG
TTTGAATTGTTTATTGCCGGGAAAGAAATCGCTAACGGCTTTAGCGAGTTGAACGATCCTTTAGATCAATTAGAACGCTT
TAAAAATCAAGTGGCTGAAAAAGAAAAAGGCGATGAAGAAGCCCAATACATGGATGAAGATTATGTGTGGGCGTTAGCCC
ATGGAATGCCCCCCACTGCAGGGCAAGGCATAGGCATTGATAGATTAGTGATGCTACTCACTGGGGCTAAAAGCATTAAA
GATGTGATTTTATTCCCAGCGATGCGTCCTGTTAAAAACGATTTTAATGTGGAGAGTGAAGAATAA

Protein sequence :
MFSNQYIQQRIHKANSLREEGKNPYKNGLKRSLTNAAFLEKYAYVKGLEEPKDKEKCESIVGRVKLLRLMGKACFIKIED
ESAILQAYVSQNELNDEFKSLKKHLEVGDIVLVKGFPFATKTGELSVHALEFHILSKTIVPLPEKFHGLSDIELRYRQRY
LDLIVNPSVKDVFKKRSLIVSSVRKFFETEGFLEVETPMMHPIPGGANARPFITYHNALEIERYLRIAPELYLKRLIVGG
FEAVFEINRNFRNEGMDHSHNPEFTMIEFYWAYHTYEDLIELSKRLFDYLLKTLNLPSKIIYNDMEVDFNQTSVISYLDA
LETIGGISKDILEKEDRLLAYLLEQSIKVEPDLTYGKLLAEAFDHFVEHQLINPTFVTQYPIEISPLARRNDSNPNIADR
FELFIAGKEIANGFSELNDPLDQLERFKNQVAEKEKGDEEAQYMDEDYVWALAHGMPPTAGQGIGIDRLVMLLTGAKSIK
DVILFPAMRPVKNDFNVESEE

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
unnamed CAD66193.1 putative lysil-tRNA synthetase LysU Not tested PAI III 536 Protein 2e-105 50

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
lysS YP_001909675.1 lysyl-tRNA synthetase VFG1668 Protein 1e-105 50