Gene Information

Name : invC (ETA_19040)
Accession : YP_001907837.1
Strain : Erwinia tasmaniensis Et1/99
Genome accession: NC_010694
Putative virulence/resistance : Virulence
Product : ATP synthase SpaL
Function : -
COG functional category : N : Cell motility
COG ID : COG1157
EC number : -
Position : 2158316 - 2159611 bp
Length : 1296 bp
Strand : -
Note : Invasion protein InvC; necessary for efficient entry of S.typhimurium into cultured epithelial cells. catalytic subunit of a protein translocase

DNA sequence :
ATGAATCCACAATTGTTAGTCCGTCTCGCACATCCACTGCGTATCCAGGGGAGTGTTATTGAGGCATTCTTGCCGGGAAC
TAAGATTGGTGAAATTTGCGAAATTCAGAAATCGTTAATTGAAGATGATCTCTTAGGGCTTGCCCAAGTGACGGGTTTTA
ACAATGAAAATACTTTTTTGAGCCTGCTAACAGATAATTTGGGATTTTCCTGTGAGAATGTTTTGTTCCCCACGGGAAAG
CCATTTTGTATTAATGTTCATGAGGACCTGATTGGCACCATCATCGATGCTTCAGGTGCGATCAGAGGGCGCTTCGATGA
GCAGTCTGTTAATCCGTTAACTAAGAGTAAAAGTATCGTTGCGTGCAGAGCGCCGCTCGATTTTACCTTACGCAGACCCA
TTGCTGAGCCCTTGATAACCGGCATTCGGGCTATTGATGGTCTGCTGACCTGTGGTGTGGGGCAGAGGATAGGTATTTTT
GCGGCTGCAGGCTGTGGTAAAACATCTTTGATGAATATGCTCGTTACGCATTGCGAAGCTGACGTCTACGTCATAGGATT
GATTGGTGAGCGAGTTCGCGAAGTTACTGAATTCGTTGAATCCATGAAACTTTCCTCACGCCGTGCAAAAGTGATACTCG
TTTATGCAACTTCGGATCGCTCTTCTGTTGAGCGCACCAACGCAGCACAAGTTGCATCAAGTATTGCAGGATACTTTAGT
GAGTTAGGAAAAAAAGTATTACTTTTCATAGATTCTGTAACGCGCTATGCACGGGCGCTGCGTGATGTTGCCTTGAGTAT
GGGGGAGTTGCCGGCGCGACGGGGTTATCCAGCTTCAGTTTTTGAATCATTGCCGAAGCTACTTGAGCGCCCAGGTTGTT
TTATAACCGGTTCAATAACCGCATTTTATACAGTATTAATCGAAAACGAAGAAGAAGCTGATGTGATTGGCGACGAAGTG
CGTTCAATTCTTGATGGGCATATTTATCTTAGCCACAAACTTGCTGCAAAAGGACACTATCCGGCTATTGATATTCTGCA
AAGTATTAGCAGGGTTTTTTCATCAGTCACTGATGATAATCATCAGCAATTAGCGAAAGTTTTTCGCTCTTTACTACAAC
GTAAAAGCGAAATGCAGTTATACATTGATCTTGGTGAATACCGTTACGGCGAAAATGTTGATAATGACATAGCTTTCGAT
AAAGCGGGTGATATTGAATTGTTTCTTAGACAGGATCAGGAAGAGAAAGTCGATATTTCATCCTGCCTGGAGAGGTTGTA
TGGATGCGTGGTCTAA

Protein sequence :
MNPQLLVRLAHPLRIQGSVIEAFLPGTKIGEICEIQKSLIEDDLLGLAQVTGFNNENTFLSLLTDNLGFSCENVLFPTGK
PFCINVHEDLIGTIIDASGAIRGRFDEQSVNPLTKSKSIVACRAPLDFTLRRPIAEPLITGIRAIDGLLTCGVGQRIGIF
AAAGCGKTSLMNMLVTHCEADVYVIGLIGERVREVTEFVESMKLSSRRAKVILVYATSDRSSVERTNAAQVASSIAGYFS
ELGKKVLLFIDSVTRYARALRDVALSMGELPARRGYPASVFESLPKLLERPGCFITGSITAFYTVLIENEEEADVIGDEV
RSILDGHIYLSHKLAAKGHYPAIDILQSISRVFSSVTDDNHQQLAKVFRSLLQRKSEMQLYIDLGEYRYGENVDNDIAFD
KAGDIELFLRQDQEEKVDISSCLERLYGCVV

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
ysaN AAS66842.1 YsaN Not tested SSR-1 Protein 6e-123 65
invC YP_217813.1 ATP synthase SpaL Virulence SPI-1 Protein 3e-108 56
spaI NP_457288.1 secretory apparatus ATP synthase (associated with virulence) Virulence SPI-1 Protein 3e-108 56
spaI NP_806497.1 ATP synthase SpaL Virulence SPI-1 Protein 3e-108 56
invC NP_461815.1 ATP synthase SpaL Virulence SPI-1 Protein 3e-108 56
invC AAS66861.1 InvC Not tested SSR-2 Protein 3e-108 55
ECs3730 NP_311757.1 ATP synthase SpaL Not tested LIM Protein 7e-100 53
lscN AAO18044.1 LscN Virulence TTSS locus Protein 2e-80 45
hrcN AAG33879.1 HrcN Virulence Hrp PAI Protein 2e-63 44
ssaN NP_456113.1 putative type III secretion ATP synthase Virulence SPI-2 Protein 2e-71 44
ssaN NP_805086.1 type III secretion system ATPase Virulence SPI-2 Protein 2e-71 44
ssaN CAA70537.1 secretion system apparatus Virulence SPI-2 Protein 3e-71 44
ssaN NP_460380.1 type III secretion system ATPase Virulence SPI-2 Protein 4e-71 44
ssaN YP_216423.1 type III secretion system ATPase Virulence SPI-2 Protein 3e-71 44
escN AAC38383.1 EscN Virulence LEE Protein 6e-67 44
escN YP_003236088.1 translocator EscN Virulence LEE Protein 2e-66 44
hrcN NP_640767.1 type III secretion system ATPase Virulence Hrp PAI Protein 1e-71 44
hrcN YP_198730.1 type III secretion system ATPase Virulence Hrp PAI Protein 4e-72 44
hrcN AAP34339.1 HrcN Virulence Hrp PAI Protein 3e-72 44
hrpB6 BAB07852.1 HrpB6 Virulence Hrp PAI Protein 3e-72 44
hrpB6 AAF61281.1 HrpB6 Virulence Hrp PAI Protein 3e-72 44
hrcN ABQ88354.1 HrcN Virulence Hrp PAI Protein 6e-63 44
hrpJ4 AAA81942.1 HrpJ4 Virulence Hrp PAI Protein 6e-63 44
XC_3006 YP_244074.1 type III secretion system ATPase Virulence Hrp PAI Protein 2e-74 44
hrcN NP_636610.1 type III secretion system ATPase Virulence Hrp PAI Protein 2e-74 44
hrcN AAB06001.1 HrcN Virulence Hrp PAI Protein 2e-65 44
escN NP_290268.1 hypothetical protein Virulence LEE Protein 2e-66 43
escN AAC31513.1 L0034 Virulence LEE Protein 2e-66 43
ECs4568 NP_312595.1 EscN Virulence LEE Protein 2e-66 43
unnamed ACU09458.1 type III secretion apparatus H+-transporting two-sector ATPase Virulence LEE Protein 2e-66 43
unnamed AAL06369.1 EscN Virulence LEE Protein 1e-65 43
escN YP_003223475.1 translocator EscN Virulence LEE Protein 1e-66 43
escN AAK26715.1 EscN Virulence LEE Protein 1e-66 43
escN YP_003232153.1 T3SS structure protein EscN Virulence LEE Protein 7e-67 43
escN AAL57542.1 EscN Virulence LEE Protein 1e-66 43
escN CAI43874.1 EscN protein Virulence LEE Protein 9e-67 43
escN CAC81862.1 EscN protein Virulence LEE II Protein 6e-67 43
hrcN AAT96141.1 HrcN Virulence T-PAI Protein 2e-65 43
hrcN AAT96195.1 HrcN Virulence T-PAI Protein 2e-65 43
hrcN NP_791227.1 type III secretion cytoplasmic ATPase HrcN Virulence Hrp PAI Protein 1e-63 43
hrpB6 AAB08461.1 HrpB6 Virulence Hrp PAI Protein 2e-70 43
hrcN YP_362163.1 type III secretion system ATPase Virulence Hrp PAI Protein 3e-70 43
YPO0267 YP_002345348.1 type III secretion system ATPase Virulence Not named Protein 1e-74 42
hrcN AAR25633.1 type III secretion cytoplasmic ATPase HrcN Not tested Not named Protein 5e-59 42
escN AFO66300.1 putative LEE-encoded type III secretion system ATPase Virulence SESS LEE Protein 3e-65 42
escN AFO66415.1 putative LEE-encoded type III secretion system ATPase Virulence SESS LEE Protein 3e-65 42
hrcN ABA47275.1 HrcN Virulence S-PAI Protein 4e-67 41
hrcN AAT96258.1 HrcN Virulence S-PAI Protein 2e-63 41
hrcN AAT96339.1 HrcN Virulence S-PAI Protein 6e-64 41
hrcN AAT96299.1 HrcN Virulence S-PAI Protein 2e-63 41

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
invC YP_001907837.1 ATP synthase SpaL VFG1778 Protein 7e-106 58
invC YP_001907837.1 ATP synthase SpaL VFG2459 Protein 1e-114 57
invC YP_001907837.1 ATP synthase SpaL VFG0555 Protein 1e-108 56
invC YP_001907837.1 ATP synthase SpaL VFG1008 Protein 1e-97 52
invC YP_001907837.1 ATP synthase SpaL VFG0192 Protein 2e-83 46
invC YP_001907837.1 ATP synthase SpaL VFG0390 Protein 8e-78 46
invC YP_001907837.1 ATP synthase SpaL VFG0515 Protein 2e-71 44
invC YP_001907837.1 ATP synthase SpaL VFG0048 Protein 2e-79 44
invC YP_001907837.1 ATP synthase SpaL VFG0730 Protein 3e-67 44
invC YP_001907837.1 ATP synthase SpaL VFG0812 Protein 1e-66 43
invC YP_001907837.1 ATP synthase SpaL VFG2144 Protein 6e-70 42
invC YP_001907837.1 ATP synthase SpaL VFG2499 Protein 6e-56 41