Gene Information

Name : guaA (Rpic_1308)
Accession : YP_001898884.1
Strain :
Genome accession: NC_010682
Putative virulence/resistance : Unknown
Product : GMP synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0519
EC number : 6.3.5.2
Position : 1403803 - 1405422 bp
Length : 1620 bp
Strand : +
Note : contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway

DNA sequence :
ATGCACGACAAAGTCCTCATCCTTGATTTCGGCTCGCAGGTCACGCAACTGATTGCGCGGCGCGTGCGTGAAGCACACGT
CTACTGCGAAATCCATCCGAACGACGTGTCCGACGCCTTCGTGCGCGAATTCGCGCCCAAGGCGATCATCCTGTCCGGCA
GCCACGCCAGCACGTACGAAGATCATCAACTGCGCGCCCCGCAGGCCGTGTGGGACCTGGGCGTGCCGGTGCTGGGCATC
TGCTACGGCATGCAGACCATGGCCGTGCAGCTTGGCGGCAAGGTGGAGTGGAGCGACCACCGCGAATTCGGTTACGCCGA
AGTGCGCGCGCATGGCCACACCCGCCTGCTCAAGGACATCCAGGACTTCGCTACGCCCGAAGGCCACGGCATGCTCAAGG
TGTGGATGAGCCACGGCGACAAGGTCACAGAGCTGCCACCGGGCTTCAAGCTGCTGGCCTCGACGCCGAGCTGCCCCGTC
GCGGGCATGGCCGACGAGGCGCGTGGCTACTACGCGGTGCAGTTCCACCCGGAAGTCACGCACACCGTGCAGGGCCGCGC
GCTGCTCGAGCGCTTTGTGCTGGAGATCGCTGGCGCCAAGCCCGACTGGGTCATGCGCGATCACATCGACGAGGCCGTCA
AGGCGATCCGCGAGCAGGTGGGCGATGAAGAGGTGATCCTCGGCCTGTCGGGTGGCGTCGATTCTTCGGTGGCGGCGGCG
CTGATCCACCGCGCCATTGGCGACCAGCTGACCTGCGTGTTTGTCGACCATGGCCTGCTGCGCCTGGACGAAGGCAAGAT
GGTGATGGACATGTTCGCCGGCCGCCTGCATGCCAAGGTTGTGCATGTGGATGCGTCCGAGCAGTTCCTCGGCCATCTGG
CTGGCGTGACTGACCCCGAAGCCAAGCGCAAGATCATCGGCCGCGAGTTCGTTGAAGTGTTCCAGGCCGAAGCCAAGAAA
CTCAGCAACGCCAAGTGGCTGGCGCAGGGCACGATCTACCCGGATGTGGTGGAATCGGGCGGCACCAAGACCAAGAAGGC
GACGACGATCAAGAGCCACCACAACGTGGGCGGCCTGCCGGAGACGCTGGGCCTGAAGCTGCTCGAGCCGCTGCGCGACC
TGTTCAAGGATGAAGTCCGCGAGCTGGGTGTGGCGCTGGGCCTGCCGCACGAGATGGTGTATCGCCACCCGTTCCCGGGG
CCTGGCCTGGGCGTGCGCATTCTGGGTGAGGTCAAGCGTGAATATGCAGACCTGCTGCGCCGTGCCGATGCGATCTTCAT
CGAAGAGCTGCGCGGCACGAAGGCCACGGCGCAGGATGCGGCCGCCGGCCTGTGCGGCGAAGGCGATGTTGGCAAGAGCT
GGTACGACCTGACCAGCCAGGCGTTTGCGGTGTTCCTGCCGATCAAGTCCGTCGGCGTGATGGGCGATGGCCGCACATAC
GACTACGTGACGGCGCTGCGTGCAGTGCAGACCACCGACTTCATGACCGCACATTGGGCGCATCTGCCGTACGCCCTGCT
GGGCCGCGTGTCGAACCGCATCATCAACGAGGTGCGTGGTTTGAGCCGGGTCGTGTATGACGTGTCGGGCAAGCCGCCTG
CGACGATCGAGTGGGAGTGA

Protein sequence :
MHDKVLILDFGSQVTQLIARRVREAHVYCEIHPNDVSDAFVREFAPKAIILSGSHASTYEDHQLRAPQAVWDLGVPVLGI
CYGMQTMAVQLGGKVEWSDHREFGYAEVRAHGHTRLLKDIQDFATPEGHGMLKVWMSHGDKVTELPPGFKLLASTPSCPV
AGMADEARGYYAVQFHPEVTHTVQGRALLERFVLEIAGAKPDWVMRDHIDEAVKAIREQVGDEEVILGLSGGVDSSVAAA
LIHRAIGDQLTCVFVDHGLLRLDEGKMVMDMFAGRLHAKVVHVDASEQFLGHLAGVTDPEAKRKIIGREFVEVFQAEAKK
LSNAKWLAQGTIYPDVVESGGTKTKKATTIKSHHNVGGLPETLGLKLLEPLRDLFKDEVRELGVALGLPHEMVYRHPFPG
PGLGVRILGEVKREYADLLRRADAIFIEELRGTKATAQDAAAGLCGEGDVGKSWYDLTSQAFAVFLPIKSVGVMGDGRTY
DYVTALRAVQTTDFMTAHWAHLPYALLGRVSNRIINEVRGLSRVVYDVSGKPPATIEWE

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
guaA YP_001331415.1 GMP synthase Not tested vSa¥á Protein 7e-117 49
SAPIG0468 YP_005733278.1 GMP synthase [glutamine-hydrolyzing] (Glutamineamidotransferase) (GMP synthetase) Not tested SAPI-S0385 Protein 5e-117 49
SAMSHR1132_03620 YP_005324884.1 GMP synthase Not tested vSa¥á Protein 4e-117 49
guaA NP_938969.1 GMP synthase Not tested Not named Protein 1e-107 48