Gene Information

Name : guaA (CLL_A0389)
Accession : YP_001884624.1
Strain : Clostridium botulinum Eklund 17B
Genome accession: NC_010674
Putative virulence/resistance : Unknown
Product : GMP synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0519
EC number : 6.3.5.2
Position : 398194 - 399735 bp
Length : 1542 bp
Strand : +
Note : contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway

DNA sequence :
ATGAAGAGAGATTTAGTTTTAGTTATAGACTTTGGTGGACAATATAATCAATTGATTGCCAGAAGAGTAAGAGAATGTAA
TGTATATTGTGAAGTTCATCCTTATAATTTAAGTGTTGATGAAATAAAGCAAATGAATCCAAAAGGAATAATTTTTACAG
GTGGTCCGAACAGTGTATATGGTGAGAACTCTCCTTTATGTGATAAAGCTATATTTGAATTAGGTGTACCTATTTTTGGT
ATATGCTATGGTTCTCAACTTATGTCTCATATACTTGGCGGAAAGGTGGCAACTGCCCCTGTAAGTGAATATGGAAAAAC
AAAAGTTGATGTAAACATAGAATCTAAACTTTTTGAAGGTGTATCTTCTTCAACAATTTGTTGGATGAGTCATACTGATT
ACATAGAAAAAGCACCAGAAGAATTTAAAGTAATAGGTAACACTCCTGTTTGTCCTGTTGCAGCTATGGAATGTGAAGAT
AAAAATTTATACGCAGTTCAATTTCATCCAGAAGTTATGCATACAGAAGAAGGTACAAAGATGCTTTCAAATTTTGTATA
TAACATATGTGGATGTACTGGAGATTGGAAAATGGACTCATTTGTTGAAAAGACAATTGAAGAAGTTCGTCAAAAGGTTG
GAAATGGTAAAGTATTATGTGCATTATCAGGTGGTGTTGATTCATCAGTAGCAGCAGTATTACTTTCAAGAGCTGTTGGA
AAGCAGTTAACTTGTGTATTTGTTGATCATGGCTTACTTCGTAAGAATGAAGGTGATGAAGTTGAAGAAATATTTGGACC
TAATGGTCAGTATGATTTAAACTTCATTCGTGTAAATGCACAAGAAAGATTTTATGAAAAGTTAGCTGGAATAGAAGAAC
CAGAACAAAAAAGAAAAATAATTGGTGAAGAATTTATAAGAGTATTTGAAGAAGAAGCTAAAAAAATAGGAACAGTTGAT
TACCTTGTACAAGGAACTATTTATCCAGATGTAATTGAAAGTGGTCTTGGAAAATCAGCAGTTATAAAATCTCATCATAA
TGTTGGAGGACTTCCTGATTATGTTGATTTTAAAGAAATAATAGAACCTCTTAGATTACTATTTAAAGACGAAGTTCGTA
AAGCAGGGTTAGAGCTTGGAATACCTGAAAAGTTAGTGTTTAGACAGCCTTTCCCAGGTCCAGGTCTTGGAATACGTATT
ATTGGAGAAGTAACAGCTGAAAAAGTTAAAATAGTTCAAGATGCAGATGCAATATATAGAGAAGAAATTGCAAATGCAGG
AATTGATAAGGAAATTGGTCAATACTTTGCAGCTCTTACTAATATGCGTTCAGTAGGAGTTATGGGAGATGAAAGAACTT
ATGATTATGCAATTGCACTTCGTGCTGTAACTACAAGTGATTTCATGACAGCTGAAAGCGCAGATCTTCCATGGGAAGTA
CTTGGAAAAGTAACAACTAGAATTGTAAATGAAGTTAAGGGTGTTAATCGTGTAATGTATGATTGCACAGGAAAACCACC
AGCAACTATAGAGTTTGAATAA

Protein sequence :
MKRDLVLVIDFGGQYNQLIARRVRECNVYCEVHPYNLSVDEIKQMNPKGIIFTGGPNSVYGENSPLCDKAIFELGVPIFG
ICYGSQLMSHILGGKVATAPVSEYGKTKVDVNIESKLFEGVSSSTICWMSHTDYIEKAPEEFKVIGNTPVCPVAAMECED
KNLYAVQFHPEVMHTEEGTKMLSNFVYNICGCTGDWKMDSFVEKTIEEVRQKVGNGKVLCALSGGVDSSVAAVLLSRAVG
KQLTCVFVDHGLLRKNEGDEVEEIFGPNGQYDLNFIRVNAQERFYEKLAGIEEPEQKRKIIGEEFIRVFEEEAKKIGTVD
YLVQGTIYPDVIESGLGKSAVIKSHHNVGGLPDYVDFKEIIEPLRLLFKDEVRKAGLELGIPEKLVFRQPFPGPGLGIRI
IGEVTAEKVKIVQDADAIYREEIANAGIDKEIGQYFAALTNMRSVGVMGDERTYDYAIALRAVTTSDFMTAESADLPWEV
LGKVTTRIVNEVKGVNRVMYDCTGKPPATIEFE

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
SAPIG0468 YP_005733278.1 GMP synthase [glutamine-hydrolyzing] (Glutamineamidotransferase) (GMP synthetase) Not tested SAPI-S0385 Protein 1e-151 58
SAMSHR1132_03620 YP_005324884.1 GMP synthase Not tested vSa¥á Protein 1e-151 58
guaA YP_001331415.1 GMP synthase Not tested vSa¥á Protein 2e-151 58
guaA NP_938969.1 GMP synthase Not tested Not named Protein 2e-130 53