Gene Information

Name : SbBS512_A0183 (SbBS512_A0183)
Accession : YP_001883212.1
Strain :
Genome accession: NC_010660
Putative virulence/resistance : Virulence
Product : ATP synthase SpaL
Function : -
COG functional category : N : Cell motility
COG ID : COG1157
EC number : -
Position : 124501 - 125793 bp
Length : 1293 bp
Strand : +
Note : Invasion protein InvC; necessary for efficient entry of S.typhimurium into cultured epithelial cells. Probable catalytic subunit of a protein translocase

DNA sequence :
ATGAGCTATATAAAATTGCTCACTCAATTATCTTTTCCTAATAGAATCTCGGGGCCAATCTTGGAAACAAGTCTTAGTGA
TGTTTCGATTGGTGAGATTTGTAACATTCAGGCTGGAATTGAAAGTAATGAAATTATTGCAAGAGCTCAGGTTGTAGGAT
TTCATGATGAAAAAACAATATTAAGCTTGATTGGAAATTCTCGTGGACTTTCACGGCAAACGTTGATTAAGCCCACTGCC
CAGTTTCTTCATACGCAAGTCGGCCGTGGATTATTGGGAGCAGTAGTCAATCCTTTAGGGGAGGTTACTGATAAGTTTGC
TGTTACGGATAACAGTGAAATTCTTTATCGACCTGTAGATAATGCTCCTCCGCTATATAGTGAAAGGGCTGCAATTGAGA
AGCCTTTTTTAACAGGTGTTAAGGTTATTGATTCTTTACTCACGTGTGGTGAAGGACAGCGAATGGGGATTTTTGCGTCA
GCTGGTTGTGGCAAAACTTTTCTCATGAATATGCTCATTGAACATAGTAGTGCTGATATATATGTTATTGGGTTAATTGG
TGAGCGAGGTCGAGAGGTTACAGAAACGGTTGATTATTTGAAAAACTCTGAGAAAAAAAGCAGGTGTGTTTTAGTATATG
CAACTTCGGATTACTCTTCGGTTGATCGTTGTAATGCTGCATATATAGCCACTGCTATAGCCGAATTTTTTAGGACTGAA
GGACATAAAGTAGCGCTTTTTATTGATTCATTAACAAGGTATGCCAGAGCATTACGTGATGTGGCCTTAGCCGCTGGAGA
ATCACCTGCCAGAAGAGGCTATCCGGTTTCGGTTTTTGATAGCTTACCCAGACTTCTTGAAAGGCCAGGAAAGTTAAAGG
CAGGTGGCTCTATTACTGCATTTTACACTGTTCTTTTGGAGGATGATGATTTTGCTGATCCATTAGCTGAAGAGGTAAGA
TCCATTTTAGATGGACATATATATTTGAGCAGAAATCTAGCCCAAAAAGGACAATTTCCTGCAATTGATTCCTTAAAAAG
TATAAGCAGGGTATTTACACAGGTTGTTGATGAAAAACATCGTATTATGGCCGCTGCATTTCGGGAGCTACTTTCTGAAA
TAGAAGAGCTAAGGACAATTATTGACTTTGGTGAATACAAACCGGGGGAGAATGCCTCTCAGGATAAAATCTACAACAAA
ATATCTGTTGTTGAGAGTTTTCTGAAGCAAGATTATCGACTCGGTTTTACTTATGAGCAGACAATGGAGCTTATTGGTGA
AACAATTAGATAA

Protein sequence :
MSYIKLLTQLSFPNRISGPILETSLSDVSIGEICNIQAGIESNEIIARAQVVGFHDEKTILSLIGNSRGLSRQTLIKPTA
QFLHTQVGRGLLGAVVNPLGEVTDKFAVTDNSEILYRPVDNAPPLYSERAAIEKPFLTGVKVIDSLLTCGEGQRMGIFAS
AGCGKTFLMNMLIEHSSADIYVIGLIGERGREVTETVDYLKNSEKKSRCVLVYATSDYSSVDRCNAAYIATAIAEFFRTE
GHKVALFIDSLTRYARALRDVALAAGESPARRGYPVSVFDSLPRLLERPGKLKAGGSITAFYTVLLEDDDFADPLAEEVR
SILDGHIYLSRNLAQKGQFPAIDSLKSISRVFTQVVDEKHRIMAAAFRELLSEIEELRTIIDFGEYKPGENASQDKIYNK
ISVVESFLKQDYRLGFTYEQTMELIGETIR

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
spaI NP_457288.1 secretory apparatus ATP synthase (associated with virulence) Virulence SPI-1 Protein 3e-119 59
spaI NP_806497.1 ATP synthase SpaL Virulence SPI-1 Protein 3e-119 59
invC NP_461815.1 ATP synthase SpaL Virulence SPI-1 Protein 3e-119 59
invC YP_217813.1 ATP synthase SpaL Virulence SPI-1 Protein 3e-119 59
ECs3730 NP_311757.1 ATP synthase SpaL Not tested LIM Protein 1e-114 58
invC AAS66861.1 InvC Not tested SSR-2 Protein 3e-120 54
ysaN AAS66842.1 YsaN Not tested SSR-1 Protein 2e-104 51
hrcN YP_362163.1 type III secretion system ATPase Virulence Hrp PAI Protein 3e-80 47
hrpB6 AAB08461.1 HrpB6 Virulence Hrp PAI Protein 2e-80 47
hrcN AAP34339.1 HrcN Virulence Hrp PAI Protein 2e-80 47
hrpB6 BAB07852.1 HrpB6 Virulence Hrp PAI Protein 7e-81 46
hrpB6 AAF61281.1 HrpB6 Virulence Hrp PAI Protein 7e-81 46
hrcN YP_198730.1 type III secretion system ATPase Virulence Hrp PAI Protein 9e-81 46
hrcN NP_640767.1 type III secretion system ATPase Virulence Hrp PAI Protein 5e-81 46
XC_3006 YP_244074.1 type III secretion system ATPase Virulence Hrp PAI Protein 2e-79 45
hrcN NP_636610.1 type III secretion system ATPase Virulence Hrp PAI Protein 2e-79 45
ssaN YP_216423.1 type III secretion system ATPase Virulence SPI-2 Protein 2e-75 45
ssaN NP_460380.1 type III secretion system ATPase Virulence SPI-2 Protein 4e-75 45
ssaN CAA70537.1 secretion system apparatus Virulence SPI-2 Protein 3e-75 45
ssaN NP_456113.1 putative type III secretion ATP synthase Virulence SPI-2 Protein 2e-75 45
ssaN NP_805086.1 type III secretion system ATPase Virulence SPI-2 Protein 2e-75 45
hrcN AAB06001.1 HrcN Virulence Hrp PAI Protein 3e-67 44
YPO0267 YP_002345348.1 type III secretion system ATPase Virulence Not named Protein 2e-72 44
lscN AAO18044.1 LscN Virulence TTSS locus Protein 1e-81 43
hrcN AAR25633.1 type III secretion cytoplasmic ATPase HrcN Not tested Not named Protein 5e-57 43
escN YP_003232153.1 T3SS structure protein EscN Virulence LEE Protein 1e-65 43
escN YP_003236088.1 translocator EscN Virulence LEE Protein 2e-66 43
escN CAC81862.1 EscN protein Virulence LEE II Protein 8e-66 43
escN AAL57542.1 EscN Virulence LEE Protein 5e-66 43
unnamed AAL06369.1 EscN Virulence LEE Protein 2e-65 43
escN CAI43874.1 EscN protein Virulence LEE Protein 1e-65 43
escN AAK26715.1 EscN Virulence LEE Protein 5e-66 43
escN YP_003223475.1 translocator EscN Virulence LEE Protein 2e-65 43
escN AAC31513.1 L0034 Virulence LEE Protein 4e-66 43
escN NP_290268.1 hypothetical protein Virulence LEE Protein 5e-66 43
unnamed ACU09458.1 type III secretion apparatus H+-transporting two-sector ATPase Virulence LEE Protein 4e-66 43
ECs4568 NP_312595.1 EscN Virulence LEE Protein 5e-66 43
escN AAC38383.1 EscN Virulence LEE Protein 3e-66 43
hrcN AAG33879.1 HrcN Virulence Hrp PAI Protein 4e-63 42
hrcN NP_791227.1 type III secretion cytoplasmic ATPase HrcN Virulence Hrp PAI Protein 4e-63 42
hrcN AAT96141.1 HrcN Virulence T-PAI Protein 1e-63 42
hrcN AAT96195.1 HrcN Virulence T-PAI Protein 6e-64 42
hrcN ABA47275.1 HrcN Virulence S-PAI Protein 3e-70 42
escN AFO66300.1 putative LEE-encoded type III secretion system ATPase Virulence SESS LEE Protein 3e-65 41
escN AFO66415.1 putative LEE-encoded type III secretion system ATPase Virulence SESS LEE Protein 3e-65 41
hrcN AAT96299.1 HrcN Virulence S-PAI Protein 4e-64 41
hrcN AAT96339.1 HrcN Virulence S-PAI Protein 3e-64 41
hrcN AAT96258.1 HrcN Virulence S-PAI Protein 5e-64 41

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
SbBS512_A0183 YP_001883212.1 ATP synthase SpaL VFG1008 Protein 0.0 99
SbBS512_A0183 YP_001883212.1 ATP synthase SpaL VFG0555 Protein 1e-119 59
SbBS512_A0183 YP_001883212.1 ATP synthase SpaL VFG1778 Protein 5e-100 55
SbBS512_A0183 YP_001883212.1 ATP synthase SpaL VFG2459 Protein 5e-114 53
SbBS512_A0183 YP_001883212.1 ATP synthase SpaL VFG2144 Protein 5e-69 45
SbBS512_A0183 YP_001883212.1 ATP synthase SpaL VFG0048 Protein 5e-81 45
SbBS512_A0183 YP_001883212.1 ATP synthase SpaL VFG0515 Protein 2e-75 45
SbBS512_A0183 YP_001883212.1 ATP synthase SpaL VFG0192 Protein 5e-84 44
SbBS512_A0183 YP_001883212.1 ATP synthase SpaL VFG0390 Protein 4e-79 43
SbBS512_A0183 YP_001883212.1 ATP synthase SpaL VFG0730 Protein 2e-66 43
SbBS512_A0183 YP_001883212.1 ATP synthase SpaL VFG0812 Protein 2e-66 43
SbBS512_A0183 YP_001883212.1 ATP synthase SpaL VFG1254 Protein 2e-62 41
SbBS512_A0183 YP_001883212.1 ATP synthase SpaL VFG2499 Protein 9e-64 41