Gene Information

Name : tpx (SbBS512_E1557)
Accession : YP_001880157.1
Strain : Shigella boydii CDC 3083-94
Genome accession: NC_010658
Putative virulence/resistance : Virulence
Product : thiol peroxidase
Function : -
COG functional category : O : Posttranslational modification, protein turnover, chaperones
COG ID : COG2077
EC number : 1.11.1.-
Position : 1420821 - 1421327 bp
Length : 507 bp
Strand : -
Note : antioxidant activity; thioredoxin-dependent thiol peroxidase; forms homodimers in solution; shows substrate specificity to alkyl hydroperoxides; periplasmic protein

DNA sequence : 
ATGTCACAAACCGTTCATTTCCAGGGCAACCCGGTTACAGTCGCCAATTCCATCCCGCAGGCGGGTAGCAAAGCGCAGAC
TTTTACTCTCGTGGCAAAAGATCTGTCTGACGTCACCCTCGGTCAGTTTGCGGGTAAACGCAAAGTGCTGAACATTTTCC
CGAGTATTGATACCGGTGTTTGCGCCGCATCAGTACGTAAGTTTAACCAACTGGCAACCGAGATCGACAACACCGTTGTG
CTGTGTATTTCTGCCGATCTGCCGTTCGCCCAGTCTCGTTTCTGCGGCGCAGAAGGTCTGAACAACGTTATCACCCTCTC
CACTTTCCGTAACGCTGAATTTCTGCAAGCCTTCGGTGTGGCAATTGCTGATGGCCCACTGAAAGGTCTGGCAGCGCGTG
CCGTTGTGGTTATTGACGAAAATGACAATGTGATTTTCAGCCAGCTGGTGGATGAAATCACCACCGAGCCGGATTACGAA
GCAGCTCTGGCTGTACTGAAAGCATAA

Protein sequence : 
MSQTVHFQGNPVTVANSIPQAGSKAQTFTLVAKDLSDVTLGQFAGKRKVLNIFPSIDTGVCAASVRKFNQLATEIDNTVV
LCISADLPFAQSRFCGAEGLNNVITLSTFRNAEFLQAFGVAIADGPLKGLAARAVVVIDENDNVIFSQLVDEITTEPDYE
AALAVLKA

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
tpx YP_001216305.1 thiol peroxidase Not tested VPI-1 Protein 5e-36 49
tpx NP_230472.1 thiol peroxidase Virulence VPI-1 Protein 2e-36 49
tagD AAK20751.1 toxR-activated gene D protein Virulence VPI Protein 4e-36 49
tagD AAK20781.1 toxR-activated gene D protein Virulence VPI Protein 2e-36 49

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
tpx YP_001880157.1 thiol peroxidase VFG0087 Protein 7e-37 49